International Journal of Pediatrics

Clinical and Laboratory Findings in Patients with Wilson’s disease Referred to Pediatric Gastroenterology Clinic in 2018-2019

Seyed Ali Jafari; Nasrin Mahdizade; Hamid Reza Kianifar; Mohammadali Kiani; Maryam Khalesi; Zahra Abbasi Shaye; Forough Rakhshanizadeh

Volume 11, Issue 1 , January 2023, , Pages 17266-17278

https://doi.org/10.22038/ijp.2022.69052.5113

Abstract

Background: Early diagnosis and treatment of Wilson's disease in childhood can reduce long-term and life-threatening complications in these patients. Considering the lack of a database ... Read More Background: Early diagnosis and treatment of Wilson's disease in childhood can reduce long-term and life-threatening complications in these patients. Considering the lack of a database of Wilson's patients in Iranian patients, the present study was carried out with the primary objective of determining clinical and laboratory presentations in children with Wilson's disease referred to Akbar Hospital in Mashhad.Methods: This cross-sectional descriptive study was conducted on children under 18 years of age with Wilson's disease who had presented to Akbar Children's Hospital in Mashhad during 2018-2019. The acquired information included demographic information, primary clinical symptoms (hepatic, cerebral, and psychological symptoms), and laboratory findings, including liver laboratory profile (AST, ALT, and ALP tests), coagulation tests, albumin, total serum protein, and direct and indirect bilirubin, and Wilson's diagnostic tests.Results: In total, 25 patients with an average age of 15.88±4.54 years were included in this study. Hepatosplenomegaly, Kayser–Fleischer ring, and jaundice were observed in 72%, 68%, and 48% of patients, respectively. Gender of patients was not significantly correlated with the clinical and laboratory findings of Wilson’s disease (P<0.05). 24-hour urine copper level was higher than 100 micrograms in 82.6% of patients. Serum ceruloplasmin level was lower than 200 mg/liter in 90% of patients. Serum ceruloplasmin levels in patients with ascites (P=0.04) and patients with lower limb edema (P=0.02) were higher than those in patients without these findings. Moreover, a lower 24-hour urinary copper level was detected in patients with seizures (P=0.03), and patients with depression (P=0.005) compared to patients without these conditions. The 24-hour urine copper levels were higher in patients with jaundice than in those without jaundice (P=0.01).Conclusion: Hepatosplenomegaly, Kayser–Fleischer ring, and jaundice are common symptoms in under 18-year-old patients with Wilson's disease. Considering the findings regarding the high levels of serum ceruloplasmin and copper in 24-hour urine in a significant

Assessment of the Initial Clinical Presentations of Patients with Celiac Disease

Seyed Ali Jafari; Atefeh Aatarian; Hamidreza Kianifar; Mohammadali Kiani; Maryam Khalesi; Forough Rakhshanizadeh

Volume 10, Issue 12 , December 2022, , Pages 17127-17134

https://doi.org/10.22038/ijp.2022.69054.5114

Abstract

Background: The prevalence of celiac disease, which is gastrointestinal enteropathy, is increasing. This study aimed to assess the clinical presentations of celiac disease in children. Methods: ... Read More

Epidemiology of Suicidal Attempts by Poisoning and Related Risk Factors in Pregnant Women in Imam Reza Hospital, Mashhad, Iran

Anahita Alizadeh; Fatemeh Said Afkhamoshoara; Mohammad Hussein Kamaloddini; Forough Rakhshanizadeh; Mehdi Talebi

Volume 7, Issue 7 , July 2019, , Pages 9753-9758

https://doi.org/10.22038/ijp.2019.38733.3311

Abstract

Background Suicidal attempt is an important phenomenon among pregnant women in Iran. This study was designed to determine the epidemiological status and risk factors of suicidal attempts ... Read More

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Author = Forough Rakhshanizadeh

Clinical and Laboratory Findings in Patients with Wilson’s disease Referred to Pediatric Gastroenterology Clinic in 2018-2019

Abstract

Assessment of the Initial Clinical Presentations of Patients with Celiac Disease

Abstract

Epidemiology of Suicidal Attempts by Poisoning and Related Risk Factors in Pregnant Women in Imam Reza Hospital, Mashhad, Iran

Abstract