International Journal of Pediatrics

Effect of Fluoxetine Therapy on Breath-Holding Spells in Children: A Clinical Trial Study

Seyedeh Zahra Farzadfard; Farah Ashrafzadeh; Mehran Beiraghi Toosi; Hassan Mahrad Majd; Mahinosadat Shahabifar

Volume 8, Issue 1 , January 2020, , Pages 10775-10783

https://doi.org/10.22038/ijp.2019.44287.3670

Abstract

Background: Breath-holding spells (BHS) is a sudden and reflexive phenomenon that is common in infancy and early childhood. Despite the harmless nature of BHS, being subjected to this ... Read More Background: Breath-holding spells (BHS) is a sudden and reflexive phenomenon that is common in infancy and early childhood. Despite the harmless nature of BHS, being subjected to this phenomenon is very stressful for parents and sometimes requires treatment. In this study, we evaluated the efficacy of fluoxetine therapy (as an anxiolytic medication) on pediatric BHS. Materials and Methods: The present clinical trial study was carried out on 30 patients with BHS referring to Neurology Clinic of Ghaem Hospital, Mashhad, Iran, in 2018. The subjects were randomly divided into control (n = 15), and intervention (n= 15) groups. The control group was then treated with iron and the intervention group with iron and fluoxetine for 3 months. The frequency and duration of BHS before and after treatment were compared in both groups. The results were later analyzed using SPSS version 16.0. Results: The present study was carried out on 30 children. The mean of infants’ age in the control and intervention groups was 20.26 ± 5.8 and 22.46 ± 5.2 months, respectively (P>0.05). The mean frequency and the duration of BHS decreased from 8.2 ± 4.3 to 1.6 ± 2.4 times per week (p = 0.000), and from 50.66 ± 26.26 to 5.4 ± 6 seconds (p = 0.000) in the control group; and from 7.2 ± 3 to 2.06 ± 2.7 times per week (p = 0.001), and 50.66 ± 38 to 8.8 ± 7.9 seconds (p = 0.002) in the intervention group, which was indicative of a statistically significant difference. However, the difference in the mean frequency and duration of BHS in the intervention group, which represents the effect of fluoxetine, was not statistically significant (p = 0.411 and p = 0.792, respectively). Conclusion: The results of the present research confirm the effect of iron therapy on decreasing the mean frequency and duration of BHS, but also indicate the ineffectiveness of synergistic administration of fluoxetine and iron on decreasing mean frequency and duration of BHS.

The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial

Javad Akhondian; Mehran Beiraghi Toosi; Hamidreza Kianifar; Saeedeh Talebi; Omid Ghanaei

Volume 4, Issue 11 , November 2016, , Pages 3897-3906

https://doi.org/10.22038/ijp.2016.7812

Abstract

BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can ... Read More

Stem Cell Therapy in Pediatric Neurological Disorders

Farnaz Torabian; Arvin Aghayi Nejad; Arash Akhavan Rezayat; Mehran Beiraghi Toosi; Hamid Reza Rahimi; Ali Reza Ataei Nakhaie

Volume 3, Issue 3.2 , June 2015, , Pages 665-673

https://doi.org/10.22038/ijp.2015.4426

Abstract

Pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be ... Read More

Evaluation of Liver Enzymes Rising in Patients Treated with Sodium Valproate (VPA)

Javad Akhondian; Mohammad Ali Kiani; Seyed Ali Jafari; Mehran Beiraghi Toosi; Mansoureh Mirzaei Najm Abad; Hamid Ahanchian; Hamidreza Kianifar

Volume 3, Issue 3.2 , June 2015, , Pages 685-689

https://doi.org/10.22038/ijp.2015.4193

Abstract

Introduction Valproic acid (VPA, Valproate) is an eight-branch fatty acid and varies from other antiepileptic drugs. VPA use might lead to mild to severe hepatotoxicity. The aim of ... Read More

Spinal Muscular Atrophy: A Short Review Article

Farah Ashrafzadeh; Ariane Sadr-Nabavi; Nazanin Asadian; Javad Akhondian; Mehran Beiraghi Toosi

Volume 2, Issue 3.1 , July 2014, , Pages 211-215

https://doi.org/10.22038/ijp.2014.2570

Abstract

Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein ... Read More

Osteoporosis after stem cell transplantation

Maryam Khalesi; Mehran Beiraghi Toosi

Volume 2, Issue 2.3 , May 2014, , Pages 48-48

https://doi.org/10.22038/ijp.2014.2701

Abstract

Background Stem cell transplantation has become as a novel treatment for end-stage kidney, lung, heart , liver diseases and several hematologic disorders. Improved survival of ... Read More

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Author = Mehran++Beiraghi+Toosi

Effect of Fluoxetine Therapy on Breath-Holding Spells in Children: A Clinical Trial Study

Abstract

The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial

Abstract

Stem Cell Therapy in Pediatric Neurological Disorders

Abstract

Evaluation of Liver Enzymes Rising in Patients Treated with Sodium Valproate (VPA)

Abstract

Spinal Muscular Atrophy: A Short Review Article

Abstract

Osteoporosis after stem cell transplantation

Abstract