International Journal of Pediatrics

Validation of the Persian Translation of the TAND Checklist in Children with Tuberous Sclerosis Syndrome

Ghazaleh Talati; Mehran Beiraghi Toosi; Reza Nejad Shahrokh Abadi; Farah Ashrafzadeh; Javad Akhoondian; Shahrbanoo Aali; Sheyla Kianifar; Shima Imannezhad; Narges Hashemi

Volume 12, Issue 1 , January 2024, , Pages 18501-18505

https://doi.org/10.22038/ijp.2024.75853.5382

Abstract

Background: Tuberous Sclerosis Complex is an autosomal dominant heterogeneous disease that mostly affects the skin and nervous system. The goal of this study was to provide a framework ... Read More

A Single-center Randomized Clinical Trial Comparing the Treatment Efficacy of High Dose Oral Prednisolone with Intramuscular Adrenocorticotropic Hormone in Patients with Infantile Spasm

Shima Imannezhad; Javad Akhondian; Farah Ashrafzadeh; Mehran Beiraghi Toosi; Narges Hashemi; Maryam Emadzadeh; Mohammad Reza Akhondian

Volume 8, Issue 10 , October 2020, , Pages 12157-12163

Abstract

Background Infantile spasm is a rare condition in infants from 4 to 7 months old. Treatment varies in different cases. Corticosteroids and adrenocorticotropic hormone (ACTH) are the ... Read More

Effect of Fluoxetine Therapy on Breath-Holding Spells in Children: A Clinical Trial Study

Seyedeh Zahra Farzadfard; Farah Ashrafzadeh; Mehran Beiraghi Toosi; Hassan Mahrad Majd; Mahinosadat Shahabifar

Volume 8, Issue 1 , January 2020, , Pages 10775-10783

https://doi.org/10.22038/ijp.2019.44287.3670

Abstract

Background: Breath-holding spells (BHS) is a sudden and reflexive phenomenon that is common in infancy and early childhood. Despite the harmless nature of BHS, being subjected to this ... Read More Background: Breath-holding spells (BHS) is a sudden and reflexive phenomenon that is common in infancy and early childhood. Despite the harmless nature of BHS, being subjected to this phenomenon is very stressful for parents and sometimes requires treatment. In this study, we evaluated the efficacy of fluoxetine therapy (as an anxiolytic medication) on pediatric BHS. Materials and Methods: The present clinical trial study was carried out on 30 patients with BHS referring to Neurology Clinic of Ghaem Hospital, Mashhad, Iran, in 2018. The subjects were randomly divided into control (n = 15), and intervention (n= 15) groups. The control group was then treated with iron and the intervention group with iron and fluoxetine for 3 months. The frequency and duration of BHS before and after treatment were compared in both groups. The results were later analyzed using SPSS version 16.0. Results: The present study was carried out on 30 children. The mean of infants’ age in the control and intervention groups was 20.26 ± 5.8 and 22.46 ± 5.2 months, respectively (P>0.05). The mean frequency and the duration of BHS decreased from 8.2 ± 4.3 to 1.6 ± 2.4 times per week (p = 0.000), and from 50.66 ± 26.26 to 5.4 ± 6 seconds (p = 0.000) in the control group; and from 7.2 ± 3 to 2.06 ± 2.7 times per week (p = 0.001), and 50.66 ± 38 to 8.8 ± 7.9 seconds (p = 0.002) in the intervention group, which was indicative of a statistically significant difference. However, the difference in the mean frequency and duration of BHS in the intervention group, which represents the effect of fluoxetine, was not statistically significant (p = 0.411 and p = 0.792, respectively). Conclusion: The results of the present research confirm the effect of iron therapy on decreasing the mean frequency and duration of BHS, but also indicate the ineffectiveness of synergistic administration of fluoxetine and iron on decreasing mean frequency and duration of BHS.

Investigation on the Effectiveness of Holistic Multi-dimensional Treatment Model (HMTM) in Improvement of CARS Test Indicators in Children suffering from Autism Spectrum Disorder

Maryam Hojjati; Ghasem Sadeghi Bejestani; Farah Ashrafzadeh

Volume 3, Issue 2.2 , April 2015, , Pages 543-553

https://doi.org/10.22038/ijp.2015.4194

Abstract

Introduction The goal of research is investigation on the effectiveness of Holistic Multi-dimensional Treatment Model (HMTM) in improvement of CARS test indicators in children with ... Read More

Spinal Muscular Atrophy: A Short Review Article

Farah Ashrafzadeh; Ariane Sadr-Nabavi; Nazanin Asadian; Javad Akhondian; Mehran Beiraghi Toosi

Volume 2, Issue 3.1 , July 2014, , Pages 211-215

https://doi.org/10.22038/ijp.2014.2570

Abstract

Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein ... Read More

A Treatable Refractory Epilepsy: A Case Report

Javad Akhondian; Farah Ashrafzadeh; Mehran Beiraghi; Forugh Rakhshani

Volume 2, Issue 1 , January 2014, , Pages 93-96

https://doi.org/10.22038/ijp.2014.2126

Abstract

Introduction Biotinidase deficiency is a life threatening inborn error of metabolism specially when delayed in diagnosis. We report a 2-month-old male infant that presented with refractory ... Read More

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Author = Farah Ashrafzadeh

Validation of the Persian Translation of the TAND Checklist in Children with Tuberous Sclerosis Syndrome

Abstract

A Single-center Randomized Clinical Trial Comparing the Treatment Efficacy of High Dose Oral Prednisolone with Intramuscular Adrenocorticotropic Hormone in Patients with Infantile Spasm

Abstract

Effect of Fluoxetine Therapy on Breath-Holding Spells in Children: A Clinical Trial Study

Abstract

Investigation on the Effectiveness of Holistic Multi-dimensional Treatment Model (HMTM) in Improvement of CARS Test Indicators in Children suffering from Autism Spectrum Disorder

Abstract

Spinal Muscular Atrophy: A Short Review Article

Abstract

A Treatable Refractory Epilepsy: A Case Report

Abstract