International Journal of Pediatrics

The Impact of Silymarin on the Symptom Severity in Pediatric Patients with Inflammatory Bowel Disease: A Randomized Clinical Trial

Hamidreza Kianifar; Seyed Ali Jafari; Maryam Khalesi; Mohammadali Kiani; Tahereh Sadeghi; Mahmoud Reza Jaafari; Fatemeh Amani

Volume 11, Issue 10 , October 2023, , Pages 18274-18286

https://doi.org/10.22038/ijp.2023.75325.5373

Abstract

Background: Inflammatory Bowel Disease (IBD) is a multifactorial disease, posing significant challenges to public health. The aim of this study is to determine the effect of silymarin ... Read More

Evaluation of Bone Densitometry Parameters in Children with Inflammatory Bowel Disease

Hasti Javaher Dashti; Abdolreza Malek; Seyed Ail Jafari; Hamidreza Kianifar; Ramin Sadeghi; Mojtaba Meshkat

Volume 11, Issue 9 , September 2023, , Pages 18246-18256

https://doi.org/10.22038/ijp.2023.75063.5367

Abstract

Background: The present study was performed to assess densitometry indices in pediatric patients affected by Inflammatory Bowel Disease (IBD) in Mashhad city, east of Iran.Methods: ... Read More

Gastric Inflammatory Myofibroblastic Tumor as a Cause of Gastric Outlet Obstruction in Children

Seyed Ali Jafari; Mahdi Rouhbakhsh; Hamidreza Kianifar; Mohammadali Kiani; Maryam Khalesi; Nadia Danaei; Fatemeh Basirinezhad

Volume 11, Issue 2 , February 2023, , Pages 17443-17447

https://doi.org/10.22038/ijp.2023.68757.5126

Abstract

Gastric inflammatory myofibroblastic tumor (IMT) is a rare tumor that is almost seen in children with a wide range of clinical features. However, radiologic imaging and gastro endoscopy ... Read More

Clinical and Laboratory Findings in Patients with Wilson’s disease Referred to Pediatric Gastroenterology Clinic in 2018-2019

Seyed Ali Jafari; Nasrin Mahdizade; Hamid Reza Kianifar; Mohammadali Kiani; Maryam Khalesi; Zahra Abbasi Shaye; Forough Rakhshanizadeh

Volume 11, Issue 1 , January 2023, , Pages 17266-17278

https://doi.org/10.22038/ijp.2022.69052.5113

Abstract

Background: Early diagnosis and treatment of Wilson's disease in childhood can reduce long-term and life-threatening complications in these patients. Considering the lack of a database ... Read More Background: Early diagnosis and treatment of Wilson's disease in childhood can reduce long-term and life-threatening complications in these patients. Considering the lack of a database of Wilson's patients in Iranian patients, the present study was carried out with the primary objective of determining clinical and laboratory presentations in children with Wilson's disease referred to Akbar Hospital in Mashhad.Methods: This cross-sectional descriptive study was conducted on children under 18 years of age with Wilson's disease who had presented to Akbar Children's Hospital in Mashhad during 2018-2019. The acquired information included demographic information, primary clinical symptoms (hepatic, cerebral, and psychological symptoms), and laboratory findings, including liver laboratory profile (AST, ALT, and ALP tests), coagulation tests, albumin, total serum protein, and direct and indirect bilirubin, and Wilson's diagnostic tests.Results: In total, 25 patients with an average age of 15.88±4.54 years were included in this study. Hepatosplenomegaly, Kayser–Fleischer ring, and jaundice were observed in 72%, 68%, and 48% of patients, respectively. Gender of patients was not significantly correlated with the clinical and laboratory findings of Wilson’s disease (P<0.05). 24-hour urine copper level was higher than 100 micrograms in 82.6% of patients. Serum ceruloplasmin level was lower than 200 mg/liter in 90% of patients. Serum ceruloplasmin levels in patients with ascites (P=0.04) and patients with lower limb edema (P=0.02) were higher than those in patients without these findings. Moreover, a lower 24-hour urinary copper level was detected in patients with seizures (P=0.03), and patients with depression (P=0.005) compared to patients without these conditions. The 24-hour urine copper levels were higher in patients with jaundice than in those without jaundice (P=0.01).Conclusion: Hepatosplenomegaly, Kayser–Fleischer ring, and jaundice are common symptoms in under 18-year-old patients with Wilson's disease. Considering the findings regarding the high levels of serum ceruloplasmin and copper in 24-hour urine in a significant

Assessment of the Initial Clinical Presentations of Patients with Celiac Disease

Seyed Ali Jafari; Atefeh Aatarian; Hamidreza Kianifar; Mohammadali Kiani; Maryam Khalesi; Forough Rakhshanizadeh

Volume 10, Issue 12 , December 2022, , Pages 17127-17134

https://doi.org/10.22038/ijp.2022.69054.5114

Abstract

Background: The prevalence of celiac disease, which is gastrointestinal enteropathy, is increasing. This study aimed to assess the clinical presentations of celiac disease in children. Methods: ... Read More

Differentiation of Biliary Atresia from the Intrahepatic Etiology of Infantile Cholestasis with Alagille Criteria

Maryam Khalesi; Moammad Ali Kiani; Seyed Ali Jafari; Monireh Yaghoubi; Seyed Hosein Ghavami Shahri; Ali Reza Attaei Nakhaie; Nafiseh pourbadakhshan

Volume 10, Issue 9 , September 2022, , Pages 16699-16704

https://doi.org/10.22038/ijp.2022.65670.4948

Abstract

Background: Biliary atresia (BA) is an important etiology of liver disease in pediatric patients which manifests as extrahepatic cholestasis. Alagille criterion is a combination of ... Read More

HLADQ2 and HLADQ8 Alleles Are Associated with Celiac Disease in Children

Seyed Ali Jafari; Zahra Chaichi; Mohammad Hammoud; Hamidreza Kianifar; Fatemeh Mir

Volume 10, Issue 8 , August 2022, , Pages 16498-16504

https://doi.org/10.22038/ijp.2022.64904.4908

Abstract

Background: Celiac disease is the permanent intolerance to dietary gluten, the major protein component of wheat. The role of human leukocyte antigen (HLA) DQ2 heterodimer (DQA1*0501-DQB1*0201) ... Read More

The Diagnostic Value of Different Sonography Findings and Color Doppler Sonography in Detecting Biliary Atresia in Infants and Neonates

Mohammad Ali Kiani; Seyed Ali Jafari; Homa Jajarmi Khayyat; Seyed Ali Alamdaran; Masood Mahdavi Rashed; Maryam Khalesi; Elham Bakhtiari

Volume 10, Issue 7 , July 2022, , Pages 16281-16290

https://doi.org/10.22038/ijp.2022.59436.4635

Abstract

Background: Biliary atresia (BA) is one of the most common etiologies of cholestasis in infants and toddlers. The most important factor in case of patients’ prognosis is its early ... Read More

Presentation of DNA Methyltransferase 3 Beta Mutation with Immune Deficiency and Dilation of Aorta and Esophagus

Mohammad Ali Kiani; Ehsan Ghayoor Karimiani; Hamidreza Kianifar; Seyed Ali Jafari; Maryam Behmadi; Nasrin Moazzen; Hamid Ahanchian

Volume 10, Issue 5 , May 2022, , Pages 15998-16004

https://doi.org/10.22038/ijp.2022.62028.4762

Abstract

Background: Immunodeficiency, Centromeric region instability, and Facial anomalies syndrome (ICF) is a rare autosomal recessive disorder with Centromeric instability as a hallmark.Method: ... Read More

Gastrointestinal symptoms of patients with autism spectrum disorder

Seyed Ali Jafari; Niloufar Sedghi; Maryam Khalesi; Hamidreza Kianifar; Mohammad Ali Kiani; Zahra Chaichi; Alireza Sargazi; Raheleh Derafshi

Volume 10, Issue 4 , April 2022, , Pages 15730-15736

https://doi.org/10.22038/ijp.2022.61877.4749

Abstract

Background: Concern about possible GI dysfunction in ASD is intensified by high rates of feeding concerns and consequent medical sequelae in ASD. Etiological factors contributing to ... Read More

Serum Anti TTG Level as a Predictor for Severity of Iintestinal Damage in Children with Celiac Disease

Seyed Ali Jafari; Maryam Khalesi; Hamidreza Kianifar; Hoda Shojaie; Mohammad Ali Kiani

Volume 9, Issue 12 , December 2021, , Pages 15076-15082

https://doi.org/10.22038/ijp.2021.59273.4619

Abstract

Background: This study aimed at evaluating how the patient’s clinical manifestations and his/her anti TTG level are correlated with the intensity of histological damage based ... Read More

Probiotics for the Treatment of Asthma: A Systematic Review and Meta-Analysis of Randomized Trials

Hamid Ahanchian; Fatemeh Khorasani; Mohammad Ali Kiani; Maryam Khalesi; Elham Ansari; Seyed Ali Jafari; Hamidreza Kianifar

Volume 8, Issue 5 , May 2020, , Pages 11271-11285

https://doi.org/10.22038/ijp.2019.36715.3195

Abstract

Background: Asthma is a growing problem worldwide and the limitations of the current therapy for allergic asthma highlight the need for novel therapeutics. We conducted a systematic ... Read More

Identification of Dermatoglyphic Patterns in Parents of Children with Cystic Fibrosis

Hamid Reza Kianifar; Atefeh Ezzati; Seyed Ali Jafari; Mohammad Ali Kiani; Hamid Ahanchian; Hasan Karami; Ezzat Khodashenas; Arezoo Jahanbin

Volume 6, Issue 3 , March 2018, , Pages 7277-7284

https://doi.org/10.22038/ijp.2017.25219.2141

Abstract

Background Dermatoglyphics could assist in the diagnosis of congenital abnormalities. The aim of this study was to identify the dermatoglyphic patterns (finger print pattern type, total ... Read More

Probiotic or Conventional Yogurt for Treating Antibiotic-associated Diarrhea: A Clinical Trial Study

Majid Khademian; Mohammad Ali Kiani; Seyed Ali Jafari; Hamid Ahanchian; Niloofar Sedghi; Fatemeh Behmanesh; Ali Khakshour; Hamidreza Kianifar

Volume 6, Issue 3 , March 2018, , Pages 7405-7412

https://doi.org/10.22038/ijp.2018.26967.2324

Abstract

Background The popularity of probiotics is on the rise. Despite the beneficial effects of antibiotics, gastrointestinal health is at risk of diarrhea. This study aimed to investigate ... Read More

Ultrasonographic Evaluation of the Sacrococcyx and Spinal Canal in Children with Constipation

Ali Alamdaran; Mohammad Taghi Pourhoseini; Seyed Ali Jafari; Reza Shojaeian; Ali Feyzi; Masoud Pezeshki Rad

Volume 5, Issue 12 , December 2017, , Pages 6267-6274

https://doi.org/10.22038/ijp.2017.23759.2010

Abstract

Background The occult neurological disorders are an important cause of constipation in children. This study aimed to evaluate the spinal canal and lumbosacral by ultrasound in pediatric ... Read More

Quality Of Life in Children with Celiac Disease: A Cross-sectional Study

Seyed Ali Jafari; Saeedeh Talebi; Nazanin Mostafavi; Fatemeh Moharreri; Hamidreza Kianifar

Volume 5, Issue 7 , July 2017, , Pages 5339-5349

https://doi.org/10.22038/ijp.2017.23860.2017

Abstract

Background Celiac disease (CD) is a systemic autoimmune disorder due to immune response triggered by ingestion of gluten in the diet. Treatment with lifelong gluten-free diet may impact ... Read More

Effect of Gastric Acid Suppressant Prophylaxis on Incidence of Gastrointestinal Bleeding in Pediatric Intensive Care Unit

Tahoora Abdollahi; Alireza Sabzevari; Ali Khakshour; Alireza Ataiee Nakhaie; Majid Sezavar; Toktam Etezadie; hamidreza kianifar; Seyed Ali Jafari; Mohammad Ali Kiani

Volume 4, Issue 11 , November 2016, , Pages 3917-3924

https://doi.org/10.22038/ijp.2016.7315

Abstract

Background: Critically ill children admitted to pediatric intensive care unit (PICU) are at increased risk of gastrointestinal bleeding due to stress related mucosal injury. Reducing ... Read More Background: Critically ill children admitted to pediatric intensive care unit (PICU) are at increased risk of gastrointestinal bleeding due to stress related mucosal injury. Reducing gastric acid by acid suppressant medication is the accepted prophylaxis treatment, but there is not any definitive guideline for using prophylaxis in PICU patients. The present study aimed to assess the effect of Proton Pump Inhibitor (PPI) and H2 Blocker (H2B) prophylaxis on gastrointestinal bleeding in admitted patients of PICU, Mashhad- Iran.Materials and Methods: In this study, 100 patients admitted in PICU divided into two equal groups on the first day of admission. They received ranitidine or pantoprazole as prophylaxis of stress ulcer. Those patients who had history of gastrointestinal bleeding or coagulation disorder were excluded. 100 PICU patients who had not received prophylaxis during last 6 months retrospectively evaluated as control of the study. Data were collected as demographic characteristics, admission reason, definitive diagnosis, receiving corticosteroid and mechanical ventilation in each patient. Gastrointestinal bleeding (hematemesis, coffee ground aspirate, and melena) and clinically significant gastrointestinal bleeding were daily monitored. Data analyzed through descriptive statistical tests, Chi-square, logistic regression, t-test and using SPSS-16 software.Results: Among 204 patients (control group=105 and case group=99), incidence of gastrointestinal bleeding (GB) was 13.2% in which 6.9% of cases presented with clinically significant gastrointestinal bleeding (CSGB). Loss of consciousness and respiratory distress were the main reason of admission. There was no significant differences between the incidence of (GB) and (CSGB) in experimental and control groups (P>0.05) as well as ranitidine and pantoprazole prophylaxis (P>0.05). Significant risk factors of (GB) were mechanical ventilation and loss of consciousness and corticosteroid therapy.Conclusion: There is ambiguity about probable benefits of gastrointestinal bleeding prophylaxis in critically ill children. We proposed that prophylaxis should prescribe in patients with two or more risk factors of gastrointestinal bleeding.

Volume 12 (2024)

Volume 11 (2023)

Volume 10 (2022)

Volume 9 (2021)

Volume 8 (2020)

Volume 7 (2019)

Volume 6 (2018)

Volume 5 (2017)

Volume 4 (2016)

Volume 3 (2015)

Volume 2 (2014)

Volume 1 (2013)

Author = Seyed+Ali++Jafari

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