@article { author = {Salem, Katayoun and Aminian, Maedeh and Khamesi, Samad}, title = {Evaluation of Dento-maxillofacial Changes in Pediatric ß-Thalassemia Major Patients in Northern Iran}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5219-5227}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.22270.1862}, abstract = {Background Thalassemia is a group of congenital disorders which is characterized by a deficient synthesis of alfa or beta globulin chains in hemoglobin molecules. Due to the problems resulting from changes in face, especially in dento-maxillary regions, such patients require special attention regarding oral health. Thus in this study, we aimed to assess the dento-maxillofacial changes in Beta-thalassemia major (BTM) children and Adolescent patients in Northern Iran. Methods  BTM subjects aged 2-15 years and their systemically healthy controls were evaluated in this case-control study. Dento-maxillary changes (spacing, crowding, Posterior cross bite, open bite, deep bite, overjet), dental occlusion, and facial changes (maxillary protrusion, malar prominence, saddle nose and frontal bossing), were evaluated. Data was analyzed SPSS version 22.0. Results  There were 66 BTM patients and 66 healthy controls in this study, including 40.9% male and 59.1% females. The average age was 12 ±3.31years. Open bite (P<0.05), overjet (P<0.05) and all of the facial abnormalities (P<0.05) observed significantly more frequent in thalassemia patients, but there was no significant difference in dental occlusion status (P>0.05). Conclusion  With regarding to high prevalence of facial changes of BTM patients (57.6 %), preventive care, education and early dento-maxillofacial evaluation and management is advised.}, keywords = {Adolescent,Beta-Thalassemia,Children,Iran,Maxillofacial abnormalities}, url = {https://ijp.mums.ac.ir/article_8383.html}, eprint = {https://ijp.mums.ac.ir/article_8383_1714bf61a6a24a99b2956fb5f0e3a041.pdf} } @article { author = {Afsari, Atousa and Valizadeh, Sousan and Fatahi, Samira and Abbasnezhad, Masoomeh and Assdollahi, Maliheh}, title = {Predictors of Knowledge and Practice of Girl Students about Puberty Health}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5229-5236}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23081.1932}, abstract = {Background: Puberty and its consequence changes are one of the most important events of each person's life. Knowledge and practice about puberty health lead to successful passage of this period. This study was aimed to determine factors predicting the knowledge and practice of girl students about puberty health in Tabriz high schools. Materials and Methods: This study was a cross-sectional study conducted on 364 students in seventh and eighth grades in 2015. The participants were selected using random cluster sampling. Their knowledge, practice and socio-demographic characteristics about puberty health were collected using self-completed questionnaires which is standardized questionnaire for Iran society. General Linear Model was used for determining the socio-demographic predictors of knowledge and practice of students about puberty health. Results: The mean score of students' knowledge was 8.26±2.21 (in the range of 0-15 scores) and the mean score of students' practice was 92.3±10.0 (in the range of 32-128 scores). Fathers' education (P=0.023) and previous obtained information (P=0.001) were knowledge predictors. Adequacy of information, the kind of family and the preferred source of information were practice predictors about puberty health (P=0.03). Conclusion: Regarding the mean score of students’ knowledge and practice and their direct relationship some factors such as father’s education, it is suggested to increase the knowledge of parents especially mothers about puberty health by health providers at schools and the related organization using in present learning pamphlets, sessions and classes.}, keywords = {Knowledge,Practice,puberty,Girl students}, url = {https://ijp.mums.ac.ir/article_8645.html}, eprint = {https://ijp.mums.ac.ir/article_8645_2c07d2bb672717c914545b15179966aa.pdf} } @article { author = {Jafari Nodoushan, Abdolhamid and Khalilzadeh, Soheila and Golzar, Azam and Hassanzad, Maryam and Sayedi, Seyed Javad and Velayati, Aliakbar}, title = {Low Bone Mineral Density and Associated Factors in Patients with Cystic Fibrosis: A Cross-Sectional Study}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5237-5244}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23618.1989}, abstract = {Background: Failure to maintain bone mass density is a major complication in patients with cystic fibrosis (CF). This study was conducted to evaluate the prevalence of low bone mineral density (BMD) and also identifying associated risk factors in CF patients. Materials and Methods: Present study conducted on 59 CF patients aged 5-35 years referred to respiratory clinic of Masih Daneshvari Hospital, Tehran-Iran. BMD was measured using dual energy X-ray absorptiometry (DXA) scan. Patients were divided in two groups: cases aged 5-18 years as group A and cases over 18 years as group B. Anthropometric variables, corticosteroid usage, pulmonary function test, serum calcium, phosphate and 25-OH vitamin D were assessed and correlation of them with BMD was investigated.Results: Low BMD (Z score < -2 standard deviation) was found in 72.8% (44) of patients. There was a positive correlation between malnutrition, Forced Expiratory Volume 1 (FEV1) and BMD (r=59 and 0.47, P<0.01, respectively). Steroid therapy and Pseudomonas aeruginosa colonization correlated significantly inversely with BMD (r = -0.34 and -0.32, P<0.05). Vitamin D deficiency was found in 36.7% (18) CF patients. No significant correlation was found between 25-OH vitamin D levels and BMD (r = 0.17; P=0. 23).Conclusion: In present study, the prevalence of low BMD was about 72.8% with significant correlation with low weight, BMI (poor nutritional status), FEV1,Pseudomonas aeruginosacolonization and the use of glucocorticoids.}, keywords = {Bone mineral density,Children,Cystic fibrosis,Dual-energy X-ray absorptiometry}, url = {https://ijp.mums.ac.ir/article_8769.html}, eprint = {https://ijp.mums.ac.ir/article_8769_062b38d71cb373ab5906cf69fffac337.pdf} } @article { author = {Saghafipour, Abedin and Nejati, Jalil and Zahraei Ramazani, Alireza and Vatandoost, Hassan and Mozaffari, Ehssan and Rezaei, Fatemeh}, title = {Prevalence and Risk Factors Associated with Head Louse (Pediculus humanus capitis) in Central Iran}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5245-5254}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23413.1967}, abstract = {Background  Recognition of head lice prevalence and related risk factors contributing in spreading the disease is a step forward to the control of this important health problem. This survey was done to determine prevalence and risk factors associated with head louse (Pediculus Humanus Capitis) in Central Iran. Materials and Methods In this descriptive–analytic study, a total of 38,237 suspected cases of head lice infestation that were referred to public health centers in Qom province during 2016 were studied. Data collection was done using standard check list that was conducted and approved by the Health Ministry of the Islamic Republic of Iran and physical examination of the hairsby visual inspections of scalp and hair for the presence of adult lice, nymphs, and eggs (nits) in all of suspected cases. For data analysis, Chi-square and Multiple Logistic Regression Tests were utilized. Results A total of 11,223 (29.35%) out of 38,237 suspected cases of all ages were found to have pediculosis. According to the multivariable logistic regression analysis, a significant relationship was observed between Pediculus capitis infestation and each of these factors: educational grade, family size, family income, having previous history of P. capitis infestation, number of combing per day(P<0.05). Head lice infestation was detected in 33.45% (7,182/21,469) of females and 24.09% (4,041/16,768) of males. Conclusion High prevalence of P. capitis among people of all ages, especially in students who reside in Qom province was attributable to inadequate access to health educators, health facilities, inattention to personal health, and other related factors. }, keywords = {Adolescents,Head lice,Iran,Pediculosis capitis,Prevalence}, url = {https://ijp.mums.ac.ir/article_8720.html}, eprint = {https://ijp.mums.ac.ir/article_8720_e4c60816e5b701755c6db87c9279e49d.pdf} } @article { author = {Hozoori, Mohammad and Moradi, Fariba and Hosseini-zade, Zoha and Kazemian, Masoomeh and Arsang-jang, Shahram}, title = {Age at Menarche and its Relationship to Anthropometric Indices in Adolescent Girls}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5255-5262}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.22352.1872}, abstract = {Background Menarche is a substantial and important period in the health of adolescent girls’, and has a significant impact on their health in the upcoming years. Accordingly, in this study, we aimed to not only determine the average age of menarche among high school girls in Qom city, but also to examine the effect of some factors on onset age of menarche. Materials and Methods In this cross-sectional study, a researcher-made questionnaire was presented to 400 girl students from six high schools in Qom city-Iran, including questions about individual characteristics, onset age of menarche in the participant and her mother, and some other indicators related to menarche. Data were analysis using SPSS version 16.0 software. Results From 400 distributed questionnaires 370 (92.5%) were filled correctly and completely. The findings of this study showed that the average age of menarche in girls has been 12.3 ± 1 year and 90% of the subjects had experienced menarche before the age of thirteen. Among the effective factors, a significant relationship was observed between daughters’ onset age of menarche and their mothers’ age (P < 0.01). Weight, Body mass index (BMI), and waist circumference (WC) was inversely and significantly associated age of menarche among the test subjects (P<0.01). Conclusion Based on the findings of this study, there was a high relationship between the onset age of menarche among the mothers and the daughters’ menarche age. Also, our results confirm that higher BMI, weight, and WC were negatively correlated to the age at onset of menarche. }, keywords = {adolescent girls,Body mass index,Menarche,waist circumference}, url = {https://ijp.mums.ac.ir/article_8374.html}, eprint = {https://ijp.mums.ac.ir/article_8374_dd7636c56f01369effc73a3f2002b940.pdf} } @article { author = {Babakhani, Maryam and Safari, Roya and Rajati, Fatemeh and Salimi, Syrus and Omidian doost, Ali}, title = {Prevalence and Risk Factors Associated with Intestinal Parasitic Infections among School Children in Gashky, West of Iran}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5263-5273}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23173.1949}, abstract = {Background Parasitic intestinal infections (IPIs) represent as the greatest cause of illnesses and diseases worldwide, especially in less developed countries. People of all ages are affected by IPIs; although, children are the most affected. This study aimed to assess prevalence and risk factors associated with IPIs among school children in West of Iran. Materials and Methods This cross-sectional study was conducted on 200 school children who selected randomly among 390 attending health care centers in Gashki, West Iran in 2016. This study we used a validated questionnaire and stool tests to gather epidemiological and disease data. The samples were examined for the presence of the parasites by direct wet mount, Lugol's iodine solution and modified formaline-ethyl acetate sedimentation methods. Chi- square and binary logistic regression procedure was applied to test the association between the variables. A p-value of Results The mean and standard deviation of children ages were 10.7±2.29 years old. The overall prevalence of the IPIs was estimated at 66 (33.0). The highest prevalence of the IPIs was related to Blastocystis 35 (17.5%), and Giardia lamblia 22 (11.0%), respectively. 18 (9.0%) out of 66 infected children had double infection. Male gender (Adjusted odds ratio (AOR): 2.20 95% Confidence Interval (CI): 1.19-4.09) was only factor significantly associated with the prevalence of the IPIs in this population. Conclusion The present study found a high rate of prevalence of parasitic intestinal infections among school children in Gashky, West of Iran. The current study highlights the importance of testing for intestinal parasites in children aged school, and emphasizes the necessity of school-based prevention and control programs. }, keywords = {Children,Intestinal disease,Iran,Parasites,Prevalence,Risk factors}, url = {https://ijp.mums.ac.ir/article_8654.html}, eprint = {https://ijp.mums.ac.ir/article_8654_03742c5659c799510681ba1128c5675e.pdf} } @article { author = {Ghaffari, Mohtasham and Rakhshanderou, Sakineh and Mehrabi, Yadollah and Tizvir, Afsoon}, title = {Using Social Network of TELEGRAM for Education on Continued Breastfeeding and Complementary Feeding of Children among Mothers: a Successful Experience from Iran}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5275-5286}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.22849.1915}, abstract = {Background: Distanceeducation for mothers with suckling babies can have a high effect and more proponents due to short time of such mothers as well as other problems like bringing infant with themselves. Authors of this research have shared an experience on application of social network of Telegram for educational intervention in field of continued breast feeding and complementary feeding of children among Iranian women. Materials and Methods: In this research, social network of Telegram was employed to provide teachings associated with continued breastfeeding and complementary feeding of children to mothers based on the model of Center for Diseases Control of USA (CDC). 90 members, out of 125 mothers who were informed, became member of Telegram group voluntary with informed consent,namely that the participation rate was 72%. The Telegram group called "Mother’s love - Mother’s milk" was designed on August 2016 and has been active for 6 months until this date. The group has been active under the management of an experienced physician and consultation with a pharmacist. Results: Participants of this research reported cell phone, internet, physician, books, and journals as the most-used sources, respectively, to access to information about breast feeding and health of their children. Only five mother of group-member mothers were uneducated or had elementary education level. Also, it was determined that the higher percentage of women who joined Telegram group were housewives compared with the group who had no tendency to join group. 100% of members evaluated membership in Telegram group and subjects related to complementary feeding beneficial and 39 of 41 (95%) participants in an E-survey, were satisfied with learning, and 35 members (85.4%) were satisfied with teaching. Conclusion: This study highlights the importance of social networks as potential educational field. Usage of this media, particularly among women groups under specific circumstance of pregnancy, can be beneficial. }, keywords = {Social networks,TELEGRAM,Education,Breast Feeding}, url = {https://ijp.mums.ac.ir/article_8570.html}, eprint = {https://ijp.mums.ac.ir/article_8570_f39e3f24656108f718519319904f86e2.pdf} } @article { author = {Maamouri, Gholamali and Boskabadi, Hassan and zghandi, Mehri and Sayedi, Seyed Javad and Bagheri, Fatemeh and Boskabadi, Abbac}, title = {The Evaluation of Serum Procalcitonin Levels in Neonatal Infections}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5287-5294}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23415.1968}, abstract = {Background Procalcitonin is known as one of the bacteremia and sepsis markers such as cytokines, interleukin and reactive proteins. This study was conducted to determine the procalcitonin levels in neonatal sepsis. Materials and Methods In a cross-sectional study, the serum procalcitonin levels in 50 term newborns with suspected sepsis was compared with 50 healthy newborns in Ghaem Hospital, Mashhad-Iran, from 2013 to 2015. The newborns were divided in two groups of clinical infection [two or more clinical symptoms (such as lethargy, apnea, respiratory distress, restlessness, seizures, need for mechanical ventilation, abdominal distention, hypotension and oral intolerance) as well as two positive laboratory symptoms], and control group (less than 2 clinical symptoms improved within 24 hours or healthy term newborns). Finally, the serum procalcitonin levels was compared with CBC, ESR and CRP. The results were analyzed using SPSS version 21.0. Results The mean leukocyte count and neutrophil percentage in clinical sepsis newborns were higher than in healthy newborns (P<0.001). The mean procalcitonin levels in highly suspected sepsis and control groups were 0.14±0.03 and 0.07±0.02, respectively (P=0.002). The Sensitivity, specificity, positive and negative predictive values of procalcitonin in all patients were 92, 89, 85 and 83 percent, respectively. Conclusion In current study, the serum procalcitonin levels in newborns with clinical sepsis were about twice the normal newborns. Therefore, it seems that this marker can be helpful in early diagnosis of neonatal infections.}, keywords = {Neonatal sepsis,Newborn,Procalcitonin}, url = {https://ijp.mums.ac.ir/article_8701.html}, eprint = {https://ijp.mums.ac.ir/article_8701_65a3dac44e6e5ac80617a5d34c75b7e6.pdf} } @article { author = {Dorreh, Fatemeh and Hashemi, Seyed Mojtaba and Salehi, Sajedeh and Taheri, Majid and Almasi-Hashiani, Amir}, title = {The Effect of Probiotic in Treatment of Infantile Colic: A Randomized Clinical Trial}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5295-5303}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.22530.1884}, abstract = {Background: Infantile colic imposes a heavy financial burden on families and the healthcare system. This study was conducted to evaluate the effect of Pedilact on the treatment of infantile colic. Materials and Methods: In this randomized clinical trial, 84 infant younger than 3 months with infantile colic were divided in two groups of 42 cases each- probiotic and standard treatment. This study was done in Arak city, Iran between 2013 and 2016. The population of the study consisted of breastfed infants and formula-fed infants younger than 3 months (less than 13 weeks) who referred to Amir Kabir Hospital and pediatric clinics presenting crying and restlessness symptoms consistent with the modified Wessel criteria. In the treatment group, in addition to the main treatment, five drops of Pedilact (Iran) was daily administered for 28 days. In both groups, the main treatment was instructed to the parents and they were advised to do the following techniques to pacify the infant: making relaxing sounds or vocals, applying peaceful and rhythmic rocking motion, walking, and using mild tremor-like movements. Results: In Pedilact and control groups, 54.75% and 28.57% of the cases were male, respectively. 23 infants (75.61%) in the Pedilact group and 33 infants (82.5%) in the control group were breastfed infants. The mean age of infants in Pedilact and control groups were 6.64 + 2.90 and 6.69 + 5.97, respectively.There was no significant difference between the Pedilact and control groups in terms of mean duration of crying time during a day (P= 0.075), and the number of crying attacks per day (P= 0.127), there was a significant decrease in both variables over time, but the mean for hours of sleep in the group receiving the standard treatment was significantly higher than that of the group receiving Pedilact (P= 0.001). Conclusion: There was no significant difference between the control and Pedilact groups in terms of crying time during a day and the number of crying attacks. It should be mentioned that, in this study, sample size was relatively low; hence, a multicenter study is recommended.  }, keywords = {Colic,Infant,Pedilact,Probiotics}, url = {https://ijp.mums.ac.ir/article_8510.html}, eprint = {https://ijp.mums.ac.ir/article_8510_34b1a0c807a8aaf46a782ee3dd9465df.pdf} } @article { author = {Nazari, Babak and Bakhshi, Saeedeh and Kaboudi, Marziyeh and Dehghan, Fateme and Ziapour, Arash and Montazeri, Nafiseh}, title = {A Comparison of Quality of Life, Anxiety and Depression in Children with Cancer and Healthy Children, Kermanshah-Iran}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5305-5314}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23540.1978}, abstract = {Background Cancer is a major public health problem in many parts of the world. The present study aimed to compare the quality of life, anxiety and depression in in children with cancer and healthy children. Materials and Methods In this descriptive and causal-comparative study, the statistical population consisted of cancer patients visiting Mohammad Kermanshahi Hospital based in Kermanshah, Iran, in the summer of 2016. Moreover, 60 samples were selected through the convenience sampling. For data collection, three questionnaires were utilized: WHO Quality of Life-BREF (WHOQOL-BREF), Children's Depression Scale (CDS), and the Revised Children's Manifest Anxiety Scale (RCMAS). Furthermore, data were analyzed through the descriptive (frequency, mean, and standard deviation) and inferential statistics (multivariate analysis of variance (MANOVA)) using the SPSS Statistics Software Version 23.0. Results The results of the present study demonstrated that there were significant differences between the cancer and healthy children in terms of all coping styles. The results also revealed that the mean scores of depression and anxiety of cancer children exceeded those of healthy children, while the mean score of cancer children’s quality of life was lower than that of healthy children. Conclusion According to the results of the present study, it can be concluded that emotional-behavioral changes are the strongest and most stable elements that make a difference in  cancer and healthy children. Hence, giving full consideration to Factors is of special importance.}, keywords = {Anxiety,Cancer,Children,Depression,Quality of life}, url = {https://ijp.mums.ac.ir/article_8739.html}, eprint = {https://ijp.mums.ac.ir/article_8739_4b58ec1d7cf4d37e6b0439661d474681.pdf} } @article { author = {Alidosti, Masoumeh and tavassoli, Elahe and Baneshi, Mahdi and Gharlipour, Zabihollah}, title = {The Determination of Physical Activity among Girl Adolescents based on Trans-theoretical model (TTM)}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5315-5326}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.22881.1916}, abstract = {Background It has been proved that physical activity has positive effects for all people. However, low activity is common among adolescents especially girl teenagers. The present study aimed to determine the condition of physical activity among girl adolescents by use of the stages of change derived from Trantheoretical model (TTM). Materials and Methods: This descriptive- analytical investigation was done (in 2016 and 2017 school year) in the first – round girl high school among 324 students studying in state schools of Shahrekord city (Western Iran). They were selected through clustering method. The data were collected by researcher-made questionnaires including demographic characteristics, knowledge construct and the stages of change (pre-contemplation, contemplation, preparation, action and maintenance). The collected data were analyzed by SPSS (version 18.0). Results The mean age of participants was 13.69+ 1.95 years old. The mean score of girls' knowledge about types of physical activity was 53.18± 21.82 (a total of 100 scores), which represents the average level of knowledge among them. The study of physical activity in students based on stages of change showed that 165 ones (43 %), 102 ones (26.6 %) and only 22 ones (5.7 %) of the studied students were in precontemplation, contemplation and maintenance stages, respectively. There was a significant relation between students' knowledge level and their mothers' age (P<0.05), their stages of change and also their fathers' education level (P<0.05). The time of student's physical activity was reported 298 minute per week. Conclusion Despite the importance of doing regular and consistent physical activity, it is obvious that this level of physical activity among studied students is not enough based on international standard; so, it is essential to focus on removing the barriers and providing suitable context for doing permanently physical activity.  }, keywords = {Adolescent,Behavior,Girl students,Physical Activity}, url = {https://ijp.mums.ac.ir/article_8572.html}, eprint = {https://ijp.mums.ac.ir/article_8572_665cbf1b711b35211bbb9c40c75ea765.pdf} } @article { author = {Sharifi, Laleh and Aghamohammadi, Asghar and Mohsenzadegan, Monireh and Rezaei, Nima and Towfighi Zavareh, Farzaneh and Moshiri, Mona and Bokaie, Saied and Barati, Anis and Sayedi, Seyed Javad and Azizi, Gholamreza and Mirshafiey, Abbas}, title = {Immunomodulation of TLR2 and TLR4 by G2013 (alfa-L-Guluronic acid) in CVID Patients}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5327-5337}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23562.1985}, abstract = {Background: Common variable immunodeficiency (CVID) is a primary immune disorder associated with hypogammaglobulinemia, recurrent infections and autoimmune diseases. CVID patients are frequently in contact with infectious pathogens leading to the activation of innate immunity through Toll-like receptors (TLR) affecting adaptive immunity. The aim of the present study was to test the immunomedulatory effect of small molecule G2013, a novel designed non-steroidal anti-inflammatory agent in CVID. Materials and Methods: After blood sampling from 16 CVID patients and 16 age- and sex-matched healthy controls, peripheral blood mononuclear cells (PBMCs) were isolated and treated with/without lipopolysaccharide (LPS), lipopolyteichoic acid (LTA), and G2013. Assessing the immunomodulatory effect of G2013, flowcytometry was done for quantify the protein expression of TLR2 and TLR4. Gene expressions of signaling molecules involved in the TLR2 and TLR4 pathways were assessed by real-time PCR. ELISA performed assessing the production of IL-1b and IL-6. Results: G2013 significantly decreased the intensity of TLR2 expression in CVID PBMCs (p=0.001) also G2013 decreased significantly the NF-kB gene expression in PBMCs of CVID patients (p=0.006). Conclusion: These results indicated that G2013 had immunomodulatory effect at least in part via TLR2 and NF-kB expression. G2013 by decreasing MFI of TLR2 expression and NFkB gene expression provide the possibility of designing new drugs for preventing or controlling autoimmunity in CVID patients.}, keywords = {alfa-L-Guluronic acid,G2013,CVID,TLR2,TLR4,NF-B,IL-6,IL-1}, url = {https://ijp.mums.ac.ir/article_8745.html}, eprint = {https://ijp.mums.ac.ir/article_8745_b5854fa7c858b31d5fac36217d4405d6.pdf} } @article { author = {Jafari, Seyed Ali and Talebi, Saeedeh and Mostafavi, Nazanin and Moharreri, Fatemeh and Kianifar, Hamidreza}, title = {Quality Of Life in Children with Celiac Disease: A Cross-sectional Study}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5339-5349}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23860.2017}, abstract = {Background Celiac disease (CD) is a systemic autoimmune disorder due to immune response triggered by ingestion of gluten in the diet. Treatment with lifelong gluten-free diet may impact negatively on the health-related quality of life and may lead to psychological disturbances. The purpose of study was to evaluate quality of life, depression and anxiety in children with celiac disease. Materials and Methods In this cross-sectional study was done between 2013 and 2014 at the Gastroenterology Outpatient Clinic (Ghaem Hospital, Mashhad- Iran), patients with serology and biopsy-proven CD, on a gluten-free diet for at least one year, were included in this study and compared with non-celiac healthy children as controls. We used the questionnaire to investigate quality of life, anxiety and depression. Results There were statistically significant differences between the mean total anxiety (state, trait) scores and depression score in the celiac patients and control group. Correlations between state and trait anxiety and depression were statistically significant (P= 0.01, r= 0.35) and (P= 0.001, r= 0.52). Reverse correlations between quality of life of CD children and anxiety (state, trait) were statistically significant (P= 0.001, r= 0.51 and P= 0.02, r= 0.32). Mean total score of quality of life was not different in the two groups, but in the physical activity component, quality of life was better in CD patients (P=0.008). Conclusion In current study, anxiety and depression had a significant impact on the course of celiac disease. }, keywords = {Anxiety,Celiac disease,Children,Depression,Gluten free diet}, url = {https://ijp.mums.ac.ir/article_8816.html}, eprint = {https://ijp.mums.ac.ir/article_8816_b98f14dfacab471afe0952311ffbb467.pdf} } @article { author = {Bhanja, Sushanta and Guha, Aritra and Samanta, Arnab and Mia, Hasen Ali and Kumar, Nitish}, title = {A Case of Empyema necessitans: An uncommon presentation of Empyema}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5351-5355}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.24070.2030}, abstract = {ABSTRACTIntroductionEmpyema is an accumulation of pus in the pleural space. Empyema necessitans occurs when pus extends through the parietal pleura into the surrounding tissues.Case ReportWe present here a 4 month old babywith severe respiratory distress and anassociated huge boggy swelling over the left side of his chest and back. Evaluation revealed pus accumulated in the pleural space which extended to the subcutaneous tissue; a case of empyema necessitans an uncommon occurrence with empyema. Early intercostal drain(ICD) insertion helped to save the baby.ConclusionEmpyema can sometimes extend beyond the pleural space into the surrounding tissue leading to empyema necessitans. Early and prompt intervention is necessary which could significantly reduce morbidity and mortality.}, keywords = {Key Words :Empyema,Empyema necessitans,ICD}, url = {https://ijp.mums.ac.ir/article_8857.html}, eprint = {https://ijp.mums.ac.ir/article_8857_a47cac06c8514c6713e5419ffbdf19de.pdf} } @article { author = {Mahdavi, Mohadese and Esmaeili-dooki, Mohammad Reza and mehrabani, Sanaz and Hajiahmadi, Mahmoud and Moghadamnia, Ali Akbar and Moslemi, Leila}, title = {The Effect of Adding Synbiotics to Polyethylene Glycol in Childhood Functional Constipation: A Randomized Clinical Trial Study}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5357-5367}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23141.1990}, abstract = {Background This study aimed to determine effects of synbiotics on treatment of functional constipation in children aged 2-10 years old. Materials and Methods This randomized single blind clinical trial study carried out on children who had functional constipation based on the Rome III criteria. The  polyethylene glycol + synbiotic group (P+S group, n=38)received the synbiotic with polyethylene glycol 0.6 gr/kg daily for 4 weeksfollowed bytonly polyethylene glycol for the following four weeks. The polyethylene glycol group (P group n=41) received polyethylene glycol for eight weeks. Then 8 after treatment, frequency of defecation, stool consistency, pain during defecation, fecal constipation and the percentage of patients who needed to continue their drug after 12 weeks treatment were compared between two groups. Results The differences in the mean frequencies of defecation (P=0.36), stool consistency (P>0.05), pain during defecation (P>0.05), incontinence (P>0.05) between the two groups at the end of eight weeks were not significant (P>0.05). The end of 12 weeks, 27.8% of (P + S) group and 15.6% of (P) group needed to continue medication more than one time /week (P>0.05). Conclusion In this study,adding synbiotic to polyethylene was not more effective than only polyethylene in the treatment of childhood functional constipation. }, keywords = {Childhood,functional constipation,polyethylene glycol,Synbiotic}, url = {https://ijp.mums.ac.ir/article_8762.html}, eprint = {https://ijp.mums.ac.ir/article_8762_f4a667bddbf9e1e7d730dfb6b74c9582.pdf} } @article { author = {Kheirollahi, Fatemeh and Rahimi, Zahra and Arsang- Jang, Shahram and Sharifirad, Gholamreza and Sarraf, Parisa and Gharlipour, Zabihollah}, title = {Puberty Health Status among Adolescent Girls: A Model- based Educational Program}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5369-5378}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23174.1950}, abstract = {Background Adolescence is the period of transition from childhood to adulthood and is one of the fastest stages of human development which is simultaneous to start of puberty. This study aimed to investigate the puberty health status among adolescent girls through a model- based educational program. Materials and Methods The current study was an interventional quasi-experimental research. It was conducted on 152 girls aged 13 to 15 years old on the city of Qom- Iran. To select the subjects, first an education zone was randomly selected. In that zone, two schools were randomly selected as the intervention and control groups (76 for interventional group and 76 for control group).After confirming the reliability and validity of a researcher-made questionnaire, it was used to collect the required data via self-reports. Data were analyzed using SPSS version 20.0 software. Results The mean age and menarche of the students were 13.59 ± 0.87 and 12.38 ± 0.99 years, respectively. There was a statistically significant difference between the mean scores of knowledge and behavior in intervention and control groups after educational intervention, so that the mean scores of knowledge and behavior about puberty health in the intervention group were higher than the control group (P< 0.05). However, there was no significant difference between the scores of Health Belief Model constructs (P > 0.05). Conclusion As the results showed, before the intervention the status of knowledge, attitude toward puberty health, and behavior about puberty health of the studied students was not favorable. Therefore, it is necessary to highlight the need for educational interventions and the role of health professionals in this field.}, keywords = {Adolescent,Educational program,health,puberty}, url = {https://ijp.mums.ac.ir/article_8655.html}, eprint = {https://ijp.mums.ac.ir/article_8655_31c2271f7d30ba599f96b47e12ab73d3.pdf} } @article { author = {Salmani, Naiire and Hasanvand, Shirin and Bagheri, Imane and Mandegari, Zahra}, title = {Nursing Care Behaviors Perceived by Parents of Hospitalized Children: A Qualitative Study}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5379-5389}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23123.1940}, abstract = {Background The professional nurses’ activities, behaviors, and manners are classified as nursing care behaviors. Nurses spend considerable amounts of time taking care of patients and their families; however, their opinions about their caring behaviors are different from the care receivers’ views. Hence, this study aimed to elaborate the nursing care behaviors perceived by the parents of hospitalized children. Materials and Methods This qualitative study was a conventional content analysis. Eighteen parents of hospitalized childrenin Yazd hospitals (Governmental and Private) were selected on the basis of a purposive sampling method and interviewed using the semi-structured interview (with the questions such as : "Why was your child hospitalized in this ward?", "How was the nurses’ behavior during the hospitalization regarding nursing care?"). The data were analyzed using the qualitative content analysis method. Results The data analysis resulted in the main theme of "fluctuation of trust in care", comprising the 8 subcategories of themes including "relieving/agitating presence", "attraction/rejection of parental participation", "respecting/ disrespecting" and "constructive/agitating communication". Conclusion The parents of hospitalized children are experiencing a variety of caring behaviors that might build or destroy their trust in nursing cares. Therefore, modification of caring behaviors can promote parents’- trust and their consequent satisfaction with the nursing cares.}, keywords = {Behavior,Nursing care,parents,Perception,trust}, url = {https://ijp.mums.ac.ir/article_8698.html}, eprint = {https://ijp.mums.ac.ir/article_8698_674b33e65dd2ebcdbfea9724e94f3f16.pdf} } @article { author = {Goudarzian, Amir Hossein and Taebei, Mozhgan and Soleimani, Aria and Tahmasbi, Mohammad and Ahmadi, Mahshid and Madani, Mohammad Hamid}, title = {Burn Specific Health Scale-Brief in Pregnant Burned Women: Translation and Psychometric Evaluation of the Persian Version}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5391-5400}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.24227.2041}, abstract = {  Background   The aim of this study was to investigate the validity and reliability of the Persian version of Burn Specific Health Scale-Brief (BSHS-B) in pregnant women suffering from burns.   Materials and Methods   This cross-cultural psychometrics study was done in 2015 to 2016 and included 410 pregnant burned patients. Participants completed BSHS-B. The face, content and construct validity of the scale were ascertained. Reliability was also assessed using internal consistency, construct reliability and intra-class correlation coefficient (ICC).   Results   Construct validity determined nine factors with an eigenvalue greater than 1. The model had a good fit [(c2(68) = 412.038, p < .05, c2/df= 4.612, GFI = .893, CFI = .912, NFI = .902, IFI = .931, RMSEA (90% C.I.) = .091 (.088 - .112)] with all factors loadings greater than 0.5 and statistically significant. The internal consistency, construct reliability and ICC were greater than 0.70.   Conclusion   Findings revealed that the Persian version of the BSHS-B is valid and reliable, and may be used to assess and evaluate quality of life in Iranian pregnant burned patients.  }, keywords = {Burn,Health Scale-Brief,Psychometric,Pregnant,Psychometrics study}, url = {https://ijp.mums.ac.ir/article_8880.html}, eprint = {https://ijp.mums.ac.ir/article_8880_3972d600387f1e5a4ac5ee107bfe8d5a.pdf} } @article { author = {Rezavand, Negin and Daryoushi, Hooman and Veisi, Firooze and Jalilian, Nassrin and Mehraban, Naghmeh}, title = {Comparison of Abdominal Aorta Intima-Media Thickness, Serum Level of Leptin, and Lipid Profile between Maternal Preeclampsia and Neonatal Outcomes}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5401-5407}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.23408.1965}, abstract = {Background Pre-eclampsia is one of the main causes of morbidity and mortality among pregnant women. This study was done with the objective of measuring abdominal aorta intima-media thickness, serum level of leptin, and lipid profile in neonates of pre-eclampsia mothers and comparing them with neonates of mothers without pre-eclampsia (control group). Materials and Methods Ninety neonates of pregnant mothers, who delivered their babies at Imam Reza Hospital of Kermanshah University of Medical Sciences, were included. They were divided into mild pre-eclampsia (15 neonates), severe pre-eclampsia (15 neonates), and control group (60 neonates). Their blood samples were delivered to the laboratory to assay leptin and lipid profile. Also, echocardiography was done to determine the thickness of intima-media of the abdominal aorta. The data were analyzed by SPSS software using Pearson correlation test and analysis of variance (for variables with normal distribution) and Spearman coefficient test and Kruskal-Wallis tests for variables with non-normal distribution. Results The minimum and maximum ages of mothers in all groups were 20 and 35 years, respectively. There was no significant difference between the mild pre-eclampsia, severe pre-eclampsia, and those without pre-eclampsia regarding serum leptin level and lipid profile (P> 0.05). However, there was significant difference between the groups regarding intima-media thickness (P< 0.05). Mean (± standard deviation) intima-media thickness was the highest in severe pre-eclampsia group (0.629±0.034) and the lowest in control group (0.472±0.058). Conclusion Neonates of mothers with pre-eclampsia had higher measurements of abdominal aorta intima-media thickness compared to control group.}, keywords = {aorta,Leptin,lipid profile,intima-media thickness,Pre-eclampsia}, url = {https://ijp.mums.ac.ir/article_8743.html}, eprint = {https://ijp.mums.ac.ir/article_8743_6544d4f708ea11f5829aa4eec538a5d9.pdf} } @article { author = {khadivzadeh, Talat and Karimi, Fatemeh zahra and Tara, Fatemeh and Bagheri, Sepideh}, title = {The Effect of Postpartum Mother–Infant Skin-to-Skin Contact on Exclusive Breastfeeding In neonatal period: A Randomized Controlled Trial}, journal = {International Journal of Pediatrics}, volume = {5}, number = {7}, pages = {5409-5417}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2016.7522}, abstract = {Background: The rate of exclusive breast feeding is low in many societies and has diminished in recent years in Iran. This study was conducted to determine the effects of postpartum mother–infant skin-to-skin contact on exclusive breastfeeding in neonatal period. Materials and Methods: This was a randomized control trial. 114 healthy primiparous mothers and their neonates were recruited in Om-ol-banin hospital in Mashhad, Iran. Upon hospital admission, mothers in active labor were allocated randomly to either SSC or routine care. In the intervention group, SSC was continuously performed during the first 2 hours post-birth. In controls as is routine Om-ol-banin hospital, the first contact and breastfeeding were initiated after repairing the routine episiotomy and delivering neonates routine care. Mothers in both groups were interviewed on the 28th days postpartum to determine the exclusive breastfeeding in neonatal period. Results: There was significant difference between two groups in the rate of breastfeeding initiation in the first 30 minutes post birth (P<0.05). The rate of exclusive breastfeeding was significantly higher in the SSC group from birth to day 28 (40.4% vs. 20%, P<0.05) and in the last 24-hour report of 28th day post-birth (70.2% vs. 46.7%, P<0.05). Conclusions: Continuous SSC during the first 2 hours of post-birth in primiparous mothers compared to routine care of baby friendly hospitals significantly enhances the rate of breastfeeding initiation in the first 30 minutes post birth and exclusive breastfeeding in the neonatal period.}, keywords = {Infant,Exclusive breastfeeding,Mother,Skin-to-skin contact}, url = {https://ijp.mums.ac.ir/article_7522.html}, eprint = {https://ijp.mums.ac.ir/article_7522_fe78b820c76870a39962719fc1efe56a.pdf} }