@article { author = {Maan, Wajiha and Warsi, Qurratul Ann and Rashed, Avideh and Karjoo, Manoochehr}, title = {Unexplained High Activity of Aspartate Aminotransferase in an Asymptomatic Pediatric Patient}, journal = {International Journal of Pediatrics}, volume = {5}, number = {10}, pages = {5805-5808}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2345-5047}, eissn = {2345-5055}, doi = {10.22038/ijp.2017.25420.2162}, abstract = {Elevated enzyme activities in plasma may at times be attributed to the presence of macro-enzymes. The macro-enzymes are often serum enzymes in complex with immunoglobulins, resulting in a greater molecular mass that cannot be filtered by renal glomeruli and are, hence, retained in the plasma. The aspartate aminotransferase (AST) can exist as a macro-enzyme, although it has been rarely reported. We describe a pediatric patient with persistently elevated serum AST activity, due to macro-enzyme formation between AST and an immunoglobulin. This is to highlight the importance of early diagnosis of macro-AST in an otherwise asymptomatic pediatric patient with isolated AST-elevation and to avoid unnecessary costly testing. }, keywords = {Alanine,Alkaline phosphatase,Aspartate Aminotransferase,Child,macro-enzymes}, url = {https://ijp.mums.ac.ir/article_9103.html}, eprint = {https://ijp.mums.ac.ir/article_9103_42dae51d73b54ac65687fc741da5a03f.pdf} }