%0 Journal Article %T Association of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study %J International Journal of Pediatrics %I Mashhad University of Medical Sciences %Z 2345-5047 %A Kalantar, Enayat %A Gharavi, Mohammand Javad %A Ghaffari Hoseini, Shervin %A Heshmat, Ramin %A Oshaghi, Mojgan %A Gharegozlou, Behnaz %A Asayesh, Hamid %A Mahdavi Gorabi, Armita %A Motlagh, Mohammad Esmaeil %A Noroozi, Mehdi %A Qorbani, Mostafa %A Kelishadi, Roya %D 2018 %\ 02/01/2018 %V 6 %N 2 %P 7045-7054 %! Association of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study %K Adolescent %K Helicobacter pylori %K Iran %K metabolic syndrome %R 10.22038/ijp.2017.24411.2060 %X Background: At least half the world’s population is colonized the stomach by Helicobacter pylori (H. pylori) which are a key constituent of the human microbiome. The aim of this study was to investigate the association of cardiometabolic risk factors with H. pylori infection in Iranian adolescents. Materials and Methods: The current study was conducted along with the third survey of a national school-based surveillance system in Iran, entitled "Childhood and Adolescence Surveillance and Prevention of Adult Non-communicable Disease" (CASPIAN) study. Detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. Trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. Fasting venous blood was examined for fasting blood sugar and lipid profile.Results: Overall 882 serum samples were suitable for testing. H. pylori antibody was found in 643 serum samples (72.9%). Among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in H. pylori positive and 42.8±11.3 in H. pylori negative group; p=0.04). Overall, 5.1% of adolescents with positive H. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). In the multivariate regression model, H. pyloriseropositivity increased the risk of overweight (OR, 3.3; 95%CI, 1.2-9.3; p= 0.03). In the multivariate model, association of other cardiometabolic risk factors with H. pylori infection was not statistically significant (p>0.05). Conclusion: Results of present study showed that H. pylori infection was associated with excess weight in adolescents. H. pylori eradication may be decrease the risk of obesity. %U https://ijp.mums.ac.ir/article_9019_27eadb4f4b14f7554c661c75a410cf94.pdf