ORIGINAL_ARTICLE
Effect of Vitamin D Supplementation on Vitamin D Levels of Term and Preterm Neonates and their Mothers: A Clinical Trial Study
Background: Vitamin D deficiency is a worldwide issue and the effect of vitamin D supplementation alone as a possible option to prevent that is still under examination.Therefore, the aim of this study was to evaluate the effect of vitamin D supplementation on term and preterm neonates and mothers for 4 months. Materials and Methods In this clinical trial, 30 term neonates and 30 preterm neonates along with their mothers created a total of 120 participants who were referred to the maternity unit of Vali-e-Asr hospital in Birjand, Iran, in 2018. Neonates and mothers were supplemented with vitamin D supplementation of 400 IU/day and 50,000 IU/month of vitamin D drops and tablets, respectively. Serum vitamin D levels of mothers and infants were measured during delivery, birth and after 4 months using ELISA method. P Results: The level of vitamin D in term and preterm neonates was 24.53±10.93 and 41.30±12.87, 19.45±8.88 and 43.78±15.51 ng/ml at birth and at 4 months of age, respectively. There was a significant difference between the mean level of vitamin D at birth and 4 months later in both infants and mothers (P<0.001). There was also a significant positive correlation between vitamin D levels of mothers during labor and neonates at birth (P<0.001). Conclusion Although vitamin D deficiency was high, regular consumption of vitamin D supplements has a significant effect on vitamin D levels and could increase the level of vitamin D to the normal levels, particularly in neonates.
https://ijp.mums.ac.ir/article_13503_d29a09db7470930cb04a064ad65a7710.pdf
2019-11-01
10311
10322
10.22038/ijp.2019.40810.3442
mothers
neonate
Supplementation
Vitamin D
Bahareh
Tanbakuchi
baharehtanbakuchi@yahoo.com
1
Resident of Pediatrics, Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.
LEAD_AUTHOR
Fatemeh
Taheri
ftaheri64@yahoo.com
2
Professor, Atherosclerosis and Coronary Artery Research Center, Department of Pediatrics, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.
AUTHOR
Mahmoud
Zardast
dr.zardast@yahoo.com
3
Associate Professor, Atherosclerosis and Coronary Artery Research Center, Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences (BUMS), Birjand, South Khorasan Province, Iran.
AUTHOR
Abbasali
Ramazani
ramazani_ab@yahoo.com
4
Social Determinants of Health Resaerch Center, Department of Epidemiology and Biostatistics, Birjand University of Medical Sciences, Birjand , Iran.
AUTHOR
ORIGINAL_ARTICLE
Hereditary Hearing Loss and Consanguinity in Turkmen Population of Iran: A Retrospective Study
Background: Our research focuses on different dimensions of families of Turkmen population of Iran with two or more than two affected members. A complete clinical ear test was conducted on them. It was aimed to find families with the highest chance of hereditary hearing impairment among siblings and also existence of consanguinity among their parents. Materials and Methods All Turkmen families with at least two hearing impaired members were screened based on prenatal and postnatal histories, family medical history, socioeconomic status as well as physical examination. For confirmation of hereditary hearing loss, a comprehensive evaluation including prenatal, perinatal and postnatal history, family medical history, pattern of inheritance, consanguinity, and three generation pedigree, the physical examination, and genetic screening by a genetic expert were used. They were referred for complete hearing evaluation including pure tone audiometry, speech recognition threshold, otoacoustic emission and auditory brainstem response. Results A total of 82 families with 198 hearing impaired patients were diagnosed with about 60% having two and the rest with more than two affected members. Nearly 89% (n=175) of the patients had the inherited type of hearing loss among which 95% (n=167) demonstrated non-syndromic symptoms. The rate of consanguinity among parents of the patients was about 65%. Conclusion This research revealed a high incidence of hereditary hearing impairment and consanguinity among Turkmen population which is in agreement with other reports from Iranian population with deaf children. In general, the rate of consanguinity in Iranian population is 38%. Therefore, it seems that consanguinity is higher in families with hearing-impaired children.
https://ijp.mums.ac.ir/article_13572_e6a3b098391999f195a1c2f41e0ee991.pdf
2019-11-01
10323
10334
10.22038/ijp.2019.41740.3519
Deafness
Consanguinity
Hereditary hearing impairment
Iran
Turkmen population
Maryam
Hajilari
maryamhajilari996@yahoo.com
1
Department of Medical Genetics, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
AUTHOR
Morteza
Oladnabi
oladnabidozin@yahoo.com
2
Congenital Malformations Research Center, Golestan University of Medical Sciences, Gorgan, Iran AND Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
LEAD_AUTHOR
Anvarsadat
Kianmehr
anvarsadat_kian@yahoo.com
3
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
AUTHOR
Mohammad Hossein
Taziki
pfk1344@gmail.com
4
Department of Otorhinolaryngology, Golestan University of Medical Sciences, Gorgan, Iran.
AUTHOR
Farzaneh
Zamiri Abdollahi
audiology_zamiri@yahoo.com
5
Audiology Department, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
ORIGINAL_ARTICLE
Investigating the Effect of TNF α (-863) and TNF α (-308) genes Polymorphism on the Progression of Disease in Patients with Cystic Fibrosis
Background: Recent studies have shown that the course of cystic fibrosis in patients with this disease differs despite the same mutation in CFTR gene. We aimed to investigate the role of polymorphism in TNF α (-308) and TNF α (-863), and its effect on the phenotype of the patients with cystic fibrosis and progression of disease. Materials and Methods: In this case-control study, 50 children with cystic fibrosis and 50 healthy children were examined for TNF-α-308 GA and TNF α - 863CA polymorphism.Four ml of citrated blood was taken from the patients in order to perform the DNA purifying and PCR-RFLP. With custom designed primers, PCR was done. Then with restriction enzymes PCR-RFLP was performed on the product of previous PCR. Changes were analyzed taking the following into consideration: diagnosis age, starting point of the pulmonary disease. Hb O2 saturation level, FEV1, and FVC. Also, for each of them, a Schwachman index basis score was calculated and results are mentioned. Results: Patient’s average age was 21±5.1 years old (ranged 5-26 years), and 48.9% (n=24) of patients were females. The average age at diagnosis was also 39.78 ±13.51 months. Patients with genotype TNF-α-308GA were older in diagnostic time compared to TNF-α-308GG genotype. However, for other variables, such as O2 sat, FEV1, FVC no difference was observed. Patients Heterozygote genotypes for “C” allele (CA) of TNF-863 have better Schwachman score than CC genotype. Conclusion The results of this research emphasize the importance of genetic factors affecting inflammatory processes. Identifying these variables is helpful in treating patients with cystic fibrosis disease.
https://ijp.mums.ac.ir/article_13491_cd819ee217479780f608616c87ab6970.pdf
2019-11-01
10335
10341
10.22038/ijp.2019.41707.3513
Cystic fibrosis
FEV1
TNF-α promoter polymorphism
Maryam
Hassanzad
mar_hassanzad@yahoo.com
1
Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Golnaz
Hajiesmail
hajiesmail.golnaz@gmail.com
2
Department of Pediatrics, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Poopak
Farnia
farnia_p@gmail.com
3
Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Jalaledin
Ghanavi
ghanavi_j@gmail.com
4
Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Ghamartaj
Khanbabayi
khanbabayi.g@gmail.com
5
Department of Pediatrics, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Mohammad
Feshangchi-Bonab
feshangchi_b_m@yahoo.com
6
Department of Pediatrics, Mofid Children's Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Ehsan
Razeghi
razeghi_e@gmail.com
7
Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Siences, Tehran, Iran.
AUTHOR
Ali Akbar
Velayati
velayati_a@gmail.com
8
Mycobacteriology Research Centre (MRC), National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
ORIGINAL_ARTICLE
Nutritional and Dietary Interventions of Autistic Spectrum Disorders: A Short Review
Autism spectrum disorder (ASD) is a neurodevelopmental condition of heterogeneous etiology, categorized by social communication deficits, repetitive or restrictive behaviors and interests. Epidemiological studies display that the incidence of autism is increasing, and the treatment of autism is vitally important. Therefore, the purpose of this article is to reorganize evidence on the effectiveness of vitamins, minerals, essential Fatty Acid, and a Gluten-Free and Casein-Free (GFCF) diet as a treatment for children with ASD. The existing nutrition and dietary therapies have been lectured and their effects on ASD symptoms have been discussed briefly considering specific research. Reviewing the studies showed that nutritional and dietary therapies improved the core symptoms of ASD. This review article investigates the importance of vitamins, minerals, essential fatty acids and GFCF diet and the recent studies suggested that nutrition and dietary supplements may play an active role in improving symptoms of ASD.
https://ijp.mums.ac.ir/article_14031_8e2cc89076c71b147c76eea7fd87a1e0.pdf
2019-11-01
10343
10348
10.22038/ijp.2019.14031
Autistic Spectrum Disorders
Autism
Child
Diet
Dietary supplements
Shereen
Hamadneh
shereen_hamadneh@yahoo.com
1
Associate Professor Pediatrics, Department of Maternal & Child Health, Princess Salma Faculty of Nursing, Al al-Bayt University, Mafraq, Jordan.
LEAD_AUTHOR
Nahla
Al-Bayyari
2
Assistant Professor Nutrition, Department of Nutrition and Food Technology, Al-Huson University College, Al-Balqa Applied University, Al-Salt, Jordan.
AUTHOR
Burhan
M. Hamadneh
3
Associate Professor Child Behavior, Talent and creativity, Department of special education, Collage of Education, Najran University, Saudi Arabia.
AUTHOR
ORIGINAL_ARTICLE
Spatial Distribution of Premature Infant Mortality in 2000-2017
Background The provision, maintenance and promotion of the health of infants as a vulnerable group in health care services are a high priority, and the first step in reducing infant mortality and improving their health is undoubtedly the identification of their mortality status. We aimed to study the spatial distribution of premature infant mortality in 194 countries in 2000-2017. Materials and Methods: In this descriptive study using reanalysis data, the data were re-analyzed. First, the infant mortality data were collected from the official website of the World Health Organization. Then, a database was created in ArcGIS 10.6 software, and the statistical tests and related maps were extracted. To this end, the Global Moran’s I and Gtis-Ord-Gi spatial correlation analyses were utilized. Data was analyzed down year by year and the charts were extracted by GIS software during a period of 18 years (2000 to 2017). Results: The results of this study demonstrated that infant mortality (0-27 days-old) followed a downward trend, but its spatial pattern was clustered (Moran’s I>0, Z-score> 2.58). We analyzed 19,041,539 data about infant mortality in 2000 to 2017. This situation was concentrated as Hot Spots in the West Pacific region and part of Asia (Central, South and Southeast Asia) from 2000 to 2017 (with 90%, 95% and 99% confidence intervals). In addition, it was revealed that there were no Cold Spots between countries. Conclusion The results of the present study demonstrated that the total infant mortality followed a downward trend, while the Hot Spots of infant mortality were in the West Pacific region and part of Asia by 2000 and remained as Hot Spots until 2017.
https://ijp.mums.ac.ir/article_13403_e49a1de29f46692100cc6fccf25dea8a.pdf
2019-11-01
10349
10359
10.22038/ijp.2019.40919.3449
Infant
Geographic Information System
Mortality
Spatial Modeling
Premature
Ali
Almasi
alialmasi@yahoo.com
1
Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Shahram
Saeidi
saedishahram@yahoo.com
2
Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
LEAD_AUTHOR
Alireza
Zangeneh
ali.zangeneh88@gmail.com
3
Social Development and Health Promotion Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Arash
Ziapour
arashziapoor@gmail.com
4
PhD Student of Health Education and Health Promotion, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Maryam
Choobtashani
m.choobtashani@gmail.com
5
Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Fariba
Saeidi
fariba.saeidi@gmail.com
6
Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Mohammad Reza
Salahshoor
reza.salahshoor@yahoo.com
7
Department of Anatomical Sciences, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Reza
Pourmirza Kalhori
rpourmirza@yahoo.com
8
Department of Medical Emergencies, School of Paramedical Science, Kermanshah University of Medical Sciences, Kermanshah, Iran.
AUTHOR
Samira
Rahimi Naderi
sr.naderi@gmail.com
9
MSc of Community Health Nursing, Department of Nursing, School of Nursing and Midwifery, Hamadan University of Medical Sciences, Hamadan, Iran.
AUTHOR
ORIGINAL_ARTICLE
Determination the Role of Endothelial Cell-Specific Molecule-1(ESM-1) in Childhood Bronchial Asthma
Background
Endothelial Cell-Specific Molecule-1 (ESM-1) is a 50 kDa soluble proteoglycan that is produced mainly the vascular endothelial cells of the kidney and lung. It is produced by the effects of proangiogenic and pro-inflammatory cytokines, and it indicates activation and dysfunction of the vascular endothelium. We aimed to detect the role of ESM-1 in children with asthma.
Materials and Methods
This study is a prospective cross sectional study and include 50 child (32 with mild persistent, 18 with moderate persistent asthma (patients) and 30 healthy children served as controls, both groups were selected from outpatient pulmonology clinic and inpatient pediatric department at children hospital, Minia University, Egypt, from 2016 to 2018; and were subjected to: detailed clinical examination, lung function test, complete blood picture and measurement of level of ESM-1 in serum.
Results
Level of ESM-1 was increased in asthmatic children compared to the controls (p=0.001). Also, the level of ESM-1 in children suffering from moderate persistent asthma was markedly higher than those with mild persistent asthma (p=0.001). In addition, ESM-1 level was positively correlated with eosinophil counts (r=0.79, p=0.01), but had negative correlation with lung functions FEV1 and PEFR (r=- 0.89, - 0.84, p=0.001).
Conclusion
ESM-1 level was increased in asthmatic children suggesting that it may have a role in asthma, furthermore, it was associated with decreased lung function indicating that it is considered as an indicator of severe asthma.
https://ijp.mums.ac.ir/article_13570_7b3577b7891dd4525fe7ef19bdc9363c.pdf
2019-11-01
10361
10367
10.22038/ijp.2019.42117.3544
Asthma
Children
Egypt
ESM-1
Abdelhakeem
Abdel Mohsen
aboueyad1@yahoo.com
1
Departments of Pediatrics Faculty of Medicine, El-Minia University, Egypt.
LEAD_AUTHOR
Rasha
Yousef
rashayousef405@yahoo.com
2
2epartments of Clinical Pathology, Faculty of Medicine, El-Minia University, Egypt.
AUTHOR
ORIGINAL_ARTICLE
Long-term Follow-up Study of Pulmonary Function Test in Children with History of Hydrocarbon Aspiration
Background Aspiration of hydrocarbons causes several acute and chronic pulmonary complications; it may even lead to death. The aim of this study was to investigate the types of long-term pulmonary complications in children with a history of hydrocarbon aspiration. Materials and Methods In this case-control study, 21 children with history of hydrocarbon aspiration in the past 1-10 years were considered as case group, and 63 children without history of toxicity were regarded as the control group. The two groups were matched in terms of age and gender. Both groups underwent physical examination (such as height, weight and body mass index), and pulmonary function tests by spirometry. Pulmonary function was categorized based on three spirometric patterns, normal, obstructive, and restrictive. In addition, the baseline characteristics of children and information obtained from clinical and paraclinical examinations during poisoning were recorded in a researcher-made checklist. The obtained data were analyzed using SPSS software (version 16.0). Results The percentage of normal, obstructive and restrictive spirometric patterns were 61.89%, 28.58%, and 9.52% in the case group, and 88.88%, 11.11% and 0% in the control group, respectively (P <0.05). In the case group, the results of spirometry test showed no association with the clinical signs and symptoms as well as the radiological findings at the time of poisoning (P> 0.05). The results of the pulmonary function test were not related to the time elapsed from poisoning (P> 0.05). Conclusion Based on the results, long-term hydrocarbon poisoning caused pulmonary dysfunction in terms of spirometric patterns in children.
https://ijp.mums.ac.ir/article_14149_e1ec5a8b8e02db61c399bbea5dc7335b.pdf
2019-11-01
10369
10375
10.22038/ijp.2019.43671.3631
Aspiration
Children
Hydrocarbons
Poisoning
Pulmonary function
Gholamreza
Panhandeh
heidari_1983@yahoo.com
1
Assistant Professor, Department of Paediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
LEAD_AUTHOR
Mohammadali
Zamani
mohammadalizamani@gmail.com
2
Assistant Professor, Department of Paediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
AUTHOR
Mohammadamin
Reisi
mohammadaminreisi@gmail.com
3
MD, Student of Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
AUTHOR
Soleyman
Kheiri
kheiri.soleiman@gmail.com
4
Professor, Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran.
AUTHOR
ORIGINAL_ARTICLE
Prevalence and Risk Factors of Technique Failure in Peritoneal Dialysis of Iranian Children and Adolescents
Background: Statistics have shown that the rate of technical failure in peritoneal dialysis (PD) is greater than hemodialysis. In this regard, the present study is aimed to determine the prevalence and risks factors of technique failure of PD in Iranian children using the country’s computerized PD data registry system. Materials and Methods: Data of 405 PD patients younger than 20 years old were extracted from Iranian PD registry. The joint models of longitudinal and time-to-event data were used to assess independent risk factors of PD technique failure. Results: PD technique failure occurred in 17.3% of the patients. 1 ng/ml increase in the baseline level of ferritin and 1 mmHg increase in the baseline systolic blood pressure will result in 0.11% (Hazard Ratio [HR]=1.0011; p=0.001), and 1.25% (HR=1.0125; p=0.046) increase in the risk of PD technique failure, respectively. In addition, 1 g/dl decrease in the baseline hemoglobin will cause a 16.25% increase in the risk of PD technique failure (HR=0.8602; p=0.026). Finally, 1 mg/l decrease in the blood urea nitrogen over time after starting PD will result in 1.75% increase in the risk of PD technique failure (HR=0.9829; p=0.006). Conclusion: The findings from this study showed that an increase in ferritin as well as systolic blood pressure at the beginning of PD increase the risk of technique failure. Furthermore, an increase in the hemoglobin level at the beginning of PD as well as an increase in the blood urea nitrogen over time after starting PD have protective impacts on pediatric PD technique failure.
https://ijp.mums.ac.ir/article_14124_77f1d72cb8c42d8478659d59d03e179e.pdf
2019-11-01
10377
10385
10.22038/ijp.2019.44136.3660
dialysis
Pediatrics
Renal Replacement Therapy
Technique failure
Mostafa
Hosseini
mhossein110@yahoo.com
1
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Shahin
Roshani
shahinroshani@ymail.com
2
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Neamatollah
Ataei
ataei_nm@yahoo.com
3
Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatric Nephrology, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Fattah
Hama Rahim Fattah
fattah.fattah@univsul.edu.iq
4
Community Medicine, College of Medicine, University of Sulaimani. Sulaimani, Iraq.
AUTHOR
Mohammed
Gubari
mohammed.jubari@gmail.com
5
Community Health Department, Technical College of Health, Sulaimani Polytechnic University, Sulaimani, Iraq.
AUTHOR
Michael
Jones
michael.jones@icr.ac.uk
6
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
AUTHOR
Iraj
Najafi
najafi266@yahoo.com
7
Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Fatemeh
Darabi
f.darabi@gmail.com
8
Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran.
AUTHOR
Simin
Darvishnoori Kalak
samanehdarvishnoori@gmail.com
9
Department of Anthropology, Faculty of Social Sciences, Islamic Azad University Central Tehran Branch, Iran.
AUTHOR
Mojtaba
Fazel
mojtabafazel@yahoo.com
10
Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Pediatric Department, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Mehdi
Yaseri
m.yaseri@gmail.com
11
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Mahmoud
Yousefifard
yousefifard.m@iums.ac.ir
12
Physiology Research Center, Faculty of Medicne, Iran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
ORIGINAL_ARTICLE
A Brief Overview of Epilepsy with Emphasis on Children
Epilepsy is a brain disorder in which a person has repeated seizures over time. A seizure is a sudden change in the electrical and chemical activity in the brain. A single seizure that does not happen again is NOT epilepsy. Most children with epilepsy live a normal life. Certain types of childhood epilepsy go away or improve with age, usually in the late teens or 20s. Nearly 80% of people with epilepsy live in low- and middle-income countries. The risk of premature death in people with epilepsy is up to three times higher than for the general population. There is no known way to prevent epilepsy. Proper diet and sleep may decrease the chances of seizures in children with epilepsy. Reduce the risk of head injury during risky activities. This can decrease the likelihood of a brain injury that leads to seizures and epilepsy. Treatment for epilepsy includes: Medicines, Lifestyle changes and Surgery. Three quarters of people with epilepsy living in low-income countries do not get the treatment they need.
https://ijp.mums.ac.ir/article_14262_8bbafa79fc21820f76f225d525f05a63.pdf
2019-11-01
10387
10395
10.22038/ijp.2019.44558.3688
Children
Epilepsy
Prevention
Symptoms
Ehsan
Keykhosravi
keykhosravie@mums.ac.ir
1
Department of Neurosurgery, Akbar Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Masumeh
Saeidi
saeidi.masumeh20@gmail.com
2
Department of Medical Education, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Mohammad Ali
Kiani
kianima@mums.ac.ir
3
Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
ORIGINAL_ARTICLE
Jaundiced Neonates Receiving Phototherapy and Risk of Atopic Dermatitis in the First 2 Years of Life: A Case-Control Study
Background Only alimited number of studies have evaluated the association between phototherapy-treated neonatal jaundice and the development of atopic dermatitis (AD) in the early childhood. In this context, the present study is aimed to assess the relationship between the AD development in the childhood and the history of phototherapy in the case of neonatal jaundice. Materials and Methods 92 children younger than two years of age who were admitted in Besat hospital and Imam Khomeini clinic (Hamadan, Iran) were enrolled in this case-control study. The subjects were classified into the case (children with AD, n=43), and control (children without AD, n=49) groups. AD was diagnosed by an allergist according to the AD diagnostic criteria. The history of neonatal jaundice treatment with phototherapy as well as the medical records of all the recruited subjects was investigated. The data were collected by physician according to clinical manifestations and medical records. The association between phototherapy-treated jaundiced neonates and developing AD was examined. Results 92 children were recruited.The mean age of the participants in the case and control groups was 10.56 and 9.89 months, respectively. About 74% (n=14) of the phototherapy-treated neonatal jaundice patients developed AD in their early childhood. Logistic regression analysis was used to evaluate the effect of jaundice treatment with phototherapy on the AD development in the early childhood. The prevalence of AD was higher in the patients with positive history of jaundice treatment with phototherapy (p < 0.05, OR=4.24, 95% CI: 1.38-13.06). Conclusion Based on the results, atopic dermatitis in early childhood was significantly associated with neonatal jaundice treatment by phototherapy.
https://ijp.mums.ac.ir/article_14058_44e97e9b85eec5ad90a9bd897053b05e.pdf
2019-11-01
10397
10403
10.22038/ijp.2019.14058
Atopic dermatitis
Hyperbilirubinemia
Neonatal Jaundice
Phototherapy
Parichehr
Bahraini
p.bahraini.pharma@gmail.com
1
Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Manoochehr
Karami
man.karami@yahoo.com
2
Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
AUTHOR
Mohammad Kazem
Sabzehei
mk_sabzehei@yahoo.com
3
Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran.
AUTHOR
Mohammad Hossein
Eslamian
mheslamian9@gmail.com
4
Clinical Research Development Unit of Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
LEAD_AUTHOR