ORIGINAL_ARTICLE
Effectiveness of Group Cognitive-Behavioral Therapy on Anxiety, Depression and Glycemic Control in Children with Type 1 Diabetes
Introduction: The present study aimed to investigate the effectiveness of group cognitive behavioral therapy in reducing anxiety and depression and glycemic control in children with type I diabetes. Methods and Matherials: The study was quasi- experimental with a pre-test, post-test design with control group. For this purpose, 30 children with diabetes were selected from Imam Reza Hospital in Mashhad. The children were randomly assigned into two experimental group (15) and control group (15). The experimental group was undergone eight 2-hour sessions of cognitive-behavioral training. Before and after the intervention, the Multidimensional Anxiety Scale for Children, which included four components of social anxiety, physical symptoms, harm avoidance, and separation anxiety, and Children Depression Inventory was administrated in both groups. Results: The findings from the covariance analysis test revealed that depression and anxiety and glycemic control in experimental group was controlled at post-test and depression score in experimental group compared to the control group at post-test was decreased. The findings from the multivariate covariance analysis test between components of, physical symptoms, harm avoidance, separation anxiety, and social anxiety revealed meaningful differences between the two groups in social anxiety post-test score. Conclusions: According to the article, cognitive behavior therapy can be effective for depression, anxiety, and blood sugar control in children.
https://ijp.mums.ac.ir/article_2555_3490805e21c1692d78f86f5f4a1c4daf.pdf
2014-07-01
165
171
10.22038/ijp.2014.2555
Cognitive-behavioral therapy
Depression
Anxiety
Glycemic control
Children
Somaye
Ahmadi
ahmadisomaye70@yahoo.com
1
Master of Clinical Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Iran
AUTHOR
Zahra
Tabibi
tabibi@um.ac.ir
2
Assistant Professor of Faculty of Education and Psychology, Ferdowsi University of Mashhad, Iran
AUTHOR
Ali
Mashhadi
mashhadi@um.ac.ir
3
Assistant Professor of Faculty of Education and Psychology, Ferdowsi University of Mashhad, Iran
AUTHOR
Peyman
Eshraghi
eshraghip2@mums.ac.ir
4
Assistant Professor of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Foad
Faroughi
faroughif891@mums.ac.ir
5
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Parisa
Ahmadi
p.ahmadi.psy@gmail.com
6
Master of Clinical Psychology, Faculty of Psychology, Ferdowsi University of Mashhad, Iran
AUTHOR
1. DiMatteo MR. The psychology of health, illness, and medical care. 1991.
1
2. Usher-Smith JA, Thompson MJ, Sharp SJ, Walter FM. Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults: a systematic review. BMJ: British Medical Journal. 2011;343.
2
3. Abolhasani F, Mohagerie Tehrani MR, Tabatabaei O, Larijani B. BURDEN OF DIABETES AND ITS COMPLICATIONS IN IRAN IN YEAR 2000. Iranian Journal of Diabetes and Lipid Disorders. 2005;5(1):35-48.
3
4. Hanas R. Type 1 diabetes in children, adolescents, and young adults: how to become an expert on your own diabetes: Class Publishing Ltd; 2007.
4
5. Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. Journal of Diabetes Investigation. 2010;1(5):212-28.
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6. Van Belle TL, Coppieters KT, Von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiological reviews. 2011;91(1):79-118.
6
7. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes a meta-analysis. Diabetes care. 2001;24(6):1069-78.
7
8. Re B. Nelson textbook of pediatrics. Philadelphia: WB Saunders. 2004:1950-74.
8
9. Pfeiffer AF, Klein HH. The treatment of type 2 diabetes. Deutsches Arzteblatt international. 2014;111(5):69-82.
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10. Rubin RR. Psychotherapy and Counselling in Diabetes Mellitus. Psychology in Diabetes Care: John Wiley & Sons, Ltd; 2002. p. 235-63.
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11. Wikner C, Gigante B, Hellenius ML, de Faire U, Leander K. The risk of type 2 diabetes in men is synergistically affected by parental history of diabetes and overweight. PloS one. 2013;8(4):e61763.
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12. Mehrabi A, Fata L, Davazdahemamy M, Rajab A. Effectiveness of cognitive-behavioral based stress management training on glycemic control and reduction of emotional problems in type 1 diabetic patients. Diabetes and lipid. 2009;8:2.
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13. D’Adamo E, Caprio S. Type 2 diabetes in youth: epidemiology and pathophysiology. Diabetes care. 2011;34(Supplement 2):S161-S5.
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14. Skinner TC, Hampson SE. Social support and personal models of diabetes in relation to self-care and well-being in adolescents with type I diabetes mellitus. Journal of adolescence. 1998;21(6):703-15.
14
15. Shaw KM, Cummings MH. Diabetes Chronic Complications: John Wiley & Sons; 2012.
15
16. Grigsby AB, Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. Prevalence of anxiety in adults with diabetes: a systematic review. Journal of psychosomatic research. 2002;53(6):1053-60.
16
17. Rubin RR. Stress and depression in diabetes. Clinical diabetes: Translating research in to Practice Sunders Elsevior Inc. 2006:269-80.
17
18. Clarke WL. Behavioral challenges in the management of childhood diabetes. Journal of diabetes science and technology. 2011;5(2):225-8.
18
19. de Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosomatic medicine. 2001;63(4):619-30.
19
20. Priyadarshini S, Aich P. Effects of psychological stress on innate immunity and metabolism in humans: a systematic analysis. PloS one. 2012;7(9):e43232.
20
21. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry. 2005;62(6):593-602.
21
22. Nejati Safa A, Larijani B, Shariati B, Amini H, Rezagholizadeh A. DEPRESSION, QUALITY OF LIFE AND GLYCEMIC CONTROL IN PATIENTS WITH DIABETES. Iranian Journal of Diabetes and Lipid Disorders. 2007;7(2):195-204.
22
23. Bradley C. Contributions of psychology to diabetes management*. British Journal of Clinical Psychology. 1994;33(1):11-21.
23
24. Anderson JR. Human symbol manipulation within an integrated cognitive architecture. Cognitive science. 2005;29(3):313-41.
24
25. Wang ML, Lemon SC, Welch G, Rosal MC. Development and validation of the Lifestyle Self-Efficacy Scale for Latinos with Diabetes (LSESLD). Ethnicity & disease. 2013;23(4):428-35.
25
26. Ji LN, Lu JM, Guo XH, Yang WY, Weng JP, Jia WP, et al. Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables. BMC public health. 2013;13:602.
26
27. Kaur G, Tee GH, Ariaratnam S, Krishnapillai AS, China K. Depression, anxiety and stress symptoms among diabetics in Malaysia: a cross sectional study in an urban primary care setting. BMC family practice. 2013;14:69.
27
28. Chorpita BF, Taylor AA, Francis SE, Moffitt C, Austin AA. Efficacy of modular cognitive behavior therapy for childhood anxiety disorders. Behavior Therapy. 2004;35(2):263-87.
28
29. Katon W, Maj M, Sartorius N. Depression and diabetes: John Wiley & Sons; 2011.
29
30. Leahy RL, Holland SJ, McGinn LK. Treatment plans and interventions for depression and anxiety disorders: Guilford Press; 2011.
30
31. Borkovec TD, Newman MG, Castonguay LG. Cognitive-behavioral therapy for generalized anxiety disorder with integrations from interpersonal and experiential therapies. CNS spectrums. 2003;8:382-9.
31
32. March JS, Parker JD, Sullivan K, Stallings P, Conners CK. The Multidimensional Anxiety Scale for Children (MASC): factor structure, reliability, and validity. Journal of the American Academy of Child & Adolescent Psychiatry. 1997;36(4):554-65.
32
33. Kovacs M, Beck AT. An empirical-clinical approach toward a definition of childhood depression. Depression in childhood: Diagnosis, treatment, and conceptual models. 1977:1-25.
33
ORIGINAL_ARTICLE
Study of Maternal Knowledge and Attitude toward Exclusive Breast Milk Feeding (BMF) in the First 6 Months of Infant in Yazd-Iran
Introduction: Breast milk is a complete food for growing children until 6 months of age, and mothers, as the most important child health care, play a decisive role in their growth. So promoting their attitude toward the benefits of breastfeeding ensures guarantee child health in the future. This study aimed to assess maternal knowledge and attitude of Mashhad toward exclusive Breast Milk Feeding (BMF)in the first 6 months of infant life. Materials and Methods: This cross-sectional descriptive-analytic study was conducted on 190 mothers who referring to Yazd health-care centers for monitoring their 6-24 month year old infants. They completed questionnaire. Participants were selected by cluster and simple random sampling. Data were analyzed by descriptive- analytic tests and using SPSS 11.5. Results: Mean score of maternal attitude toward exclusive BMF was 10.14±2.00 (out of 14) and maternal knowledge score toward advantages of breast milk was 10.12±2.015 (out of 14). The incidence of exclusive BMF in the first 6 months of life study was 72.9%. Child growth was as follows: excellent growth (24.5%) and good growth (55.3%). ANOVA showed a significant difference between parents' education and maternal attitude and maternal knowledge towards exclusive BMF; whatever higher education of parents, more positive knowledge and attitude towards exclusive BMF (P<0.05). There was a significant direct relationship between knowledge and attitude (Spearman test, P-value= 0.000& r= 0.4). Conclusion: Maternal knowledge and attitude towards exclusive BMF was moderate. It is essential to plan for mothers by officials in order to promote breast-feeding in the first 6 months of baby's life to enhance positive maternal attitude in this regard.
https://ijp.mums.ac.ir/article_2484_7bd6b377048fbe29225ffc151942aa72.pdf
2014-07-01
175
181
10.22038/ijp.2014.2484
Attitude
Exclusive Breast Milk Feeding
Infant
Knowledge
Yazd
Razieh
Esfandtari
1
MSc of Health Education, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mohammad Hosein
Baghiani Moghadam
2
Professor of Health Education , Faculty of Health, Shahid Sadughi University of Medical Sciences, Yazd, Iran.
AUTHOR
Ali
Khakshour
khakshoura@mums.ac.ir
3
Department of Pediatrics, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Foad
Faroughi
faroughif891@mums.ac.ir
4
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Behjat
Zarif
5
Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Masumeh
Saeidi
6
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
1. Holy Qur'an.
1
2. UNICEF/WHO Baby-Friendly Hospital Initiative Revised, Updated and Expanded for Integrated Care 2009 WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland www. unicef. org/nutrition /files/BFHI_2009_s3.1&2.pdf.
2
3. Horta BL, Bahl R, Martines JC, Victora CG: Evidence on the long-term effects of breastfeeding. Systematic reviews and meta-analysis. Geneva: World Health Organization 2007.
3
4. Gartner LM, Morton J, Lawrence RA, Naylor AJ, O’Hare D, Schanler RJ, Eidelman AI,American Academy of Pediatrics Section on Breastfeeding: Breastfeeding and the use of human milk. Pediatrics 2005, 115: 496-506.
4
5. Walker A. Breast milk as the gold standard for protective nutrients. J Pediatr. 2010; 156 (2Suppl):S3-7. Review.
5
6. Imani M, Mohamadi M, Rakhshani F. [Prevalence and factors associated with exclusive breastfeeding inZahedan (Persian)]. Faiz 2003; 26(7):26-33.
6
7. Abedzadeh M, Saberi F, Sadat Z.[Quality of nutrition and factors related to it in 4/5 month old babies of Kashan (Persian)]. Faiz 2005; 3: 59-64.
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8. Jones G, Steketee RW, Black RE, Bhutta ZA, Morris SS:How many child deaths can we prevent this year? Lancet 2003, 362:65-71.
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9. WHO Collaborative Study Team on the Role of Breastfeeding on the Prevention of Infant Mortality: Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis. Lancet2000, 355(9202):451-5.
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10. Scott JA, Landers MC, Hughes RM, Binns CW: Factors associated with breastfeeding at discharge and duration of breastfeeding. J Paediatr Child Health 2001, 37(3):254-61.
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11. WHO: The optimal duration of exclusive breastfeeding.Geneva 2001.
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12. Breastfeeding trends and updated national health objectives for exclusive breastfeeding United States, birth years 2000-2004. MMWR Morb Mortal Wkly Rep 2007, 56(30):760-3.
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13. Innis SM: Perinatal biochemistry and physiology of longchain polyunsaturated fatty acids. J Pediatr 2003, 143(4Suppl):S1-8.
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14. WHO: Report of the expert consultation on the optimal duration of exclusive breastfeeding World Health Organization; 2001.
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15. American Academy of Pediatrics (AAP). Work Group on Breastfeeding. Breastfeeding and the use of human milk.Pediatrics. 1997; 100(6): 1035–9.
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16. Kramer MS, Kakuma R. The optimal duration of exclusive breastfeeding: a systematic review. Geneva, World Health Organization, 2001 (WHO/NHD/01. 08;WHO/ FCH/01.23).
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17. Golkari Hamid, Khatami Reza. Study of developmental disorders (FTT and short stature). Tehran: Ayandesazan, 1999, Pages 5-7.
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18. Seddighi P, Ghafarpur M, Jazayeri A. Effect of weaning foods, infant growth and development in Eslamshahr city. Medical Journal (Journal of Medicine, Shahid Beheshti University of Medical Sciences); 21 years, 1997, Pages: 14-25.
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19. Razavieh V,Pourabdolahi P,Nikkhah S. Knowledge and attitudes of mothers about feeding infant with breastfeeding applied and supplementary foods. Journal of Urmia University of Medical Sciences, No. 2, Summer 2001, Pages 120-9.
19
20. Nakhshab M,Basiri H. Prevalence of malnutrition and its risk factors in children under 2 years of Sari 2000. Journal of Mazandaran University of Medical Sciences, Year XII, No. 34, Spring 2002, Pages: 47-56.
20
21. Kusha A. Nutritional status of children under 1 year of Hospital Medicine Branch Community in 1991-1993 years. Journal of Zanjan University of Medical Sciences, No. 20, 1995, Pages: 5-10.
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22. Xu F, Qiu L, Binns CW, Liu X. Breastfeeding in China: a review. Int Breastfeed J. 2009, 16:4-6.
22
23. United Nations Children’s Fund (UNICEF): Progress for Children: A Child Survival Report Card 2004 [http://www. unicef.org/ publications/ files/29652L01Eng.pd f].
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24. Ssenyonga R, Muwonge R, Nankya I. Towards a better understanding of exclusive breastfeeding in the era of HIV/AIDS: a study of prevalence and factors associated with exclusive breastfeeding from birth, in Rakai,Uganda. J Trop Pediatr 2004 ;50(6):348-53.
24
25. Aidam BA, Pérez-Escamilla R, Lartey A, Aidam J. Factors associated with exclusive breastfeeding in Accra,Ghana. Eur J Clin Nutr 2005; 59(6): 789-96.
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26. Ogbeide DO, Siddiqui S, Al Khalifa IM, Karim A. Breast feeding in a Saudi Arabian community. Profile of parents and influencing factors. Saudi Med J 2004; 25(5): 580-4.
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27. The state of the world’s children. 2008, [Child survival] New York: UNICEF; 2007.
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28. Santo LC, de Oliveira LD, Giugliani ER. Factors associated with low incidence of exclusive breastfeeding for the first 6 months. Birth 2007; 34(3):212-9.
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29. US. Department of Health and Human Services. Chapter 16. Maternal, Infant, and Child Health. Healthy People 2010 (2nd Ed.): With Understanding and Improving Health and Objectives for Improving Health. Vol 26.Washington, DC: US. Governmental Printing Office; 2000.
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30. Ryan AS, Zhou W, Acosta A. Breastfeeding continues to increase into the new millennium. Pediatrics. 2002;110(6): 1103–9.
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31. The Ministry of Health IR of Iran, Breastfeeding office ttp://www.bfps.ir/ (i5emlr 45w1kdeg45tov0ysem)/Persian/Home.aspx].
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32. Venancio SI, Monteiro CA. Individual and contextual determinants of exclusive breast-
32
feeding in S?o Paulo,Brazil: a multilevel analysis. Public Health Nutr 2006; 9(1): 40-6.
33
33. Mosaffa H. Survey of the knowledge and attitude of mothers during one year after delivery about breast-feeding.Journal of Guilan University of Medical Sciences 2004; 13(51): 23-31.
34
34. Alaie N, Faghihzadeh S. Relationship of Mother Factors with Mothers’ Attitude about Breast Feeding. Daneshvar Medicine April- May 2008; 15(74): 31-40.
35
35. Bertini G, Perugi S, Dani C, Pezzati M, Tronchin M, Rubaltelli FF. Maternal education and the incidence and duration of breast feeding: a prospective study J Pediatr Gastroenterol Nutr 2003; 37(4): 447-52.
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36. Sweet L, Darbyshire P. Fathers and breast feeding very-low-birthweight preterm babies Midwifery 2009; 25(5):540-53.
37
37. Gill SL, Reifsnider E, Lucke JF. Effects of support on the initiation and duration of breastfeeding. West J Nurs Res. 2007 Oct;29 (6): 708-23.
38
38. Pisacane A, Continisio GI, Aldinucci M, D'Amora S, Continisio P. A controlled trial of the father's role in breastfeeding promotion. Pediatrics. 2005 Oct;116(4):e494-8.
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39. Scott JA, Binns CW, Oddy WH, Graham KI. Predictors of breastfeeding duration: evidence from a cohort study. Pediatrics. 2006; 117(4): e646.
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40. Ertem IO, Votto N, Leventhal JM. The timing and predictors of the early termination of breastfeeding. Pediatrics. 2001 Mar; 107(3): 543-8.
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41. Mirahmadizadeh A, Zare P, Moradi F, Sayadi M, Hesami E, Moghadami M. Exclusive breast-feeding weaning pattern and its determinant factors in Fars province in 2010.. 3. 2012; 19(99):11-22.
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42. Duration of Exclusive Breastfeeding in Canada: Key Statistics and Graphics (2007-2008). http://www.hcsc. gc.ca/fnan/surveill/ nutrition/commun/prenatal/duration-dureeeng. php (Access at 4th Aug 2011)
43
43. Savage King, F. Helping breast fed mothers. Translated by Dehghani P. IUMS publications, Tehran. 1999.p 44.
44
ORIGINAL_ARTICLE
Effects of Nutritional variables in children with iron deficiency anemia
Introduction: Iron deficiency (ID) is the most prevalent nutritional disorder in the world. The prevalence of iron deficiency anemia (IDA) is about 9% in toddlers, 9-11% in adolescent girls and less than 1% in teenage boys. IDA presents when there is not sufficient iron for haemoglobin synthesis. In particular it has negative effects on the behavior, cognitive performance, immune system and physical growth of infants, preschool and school age children. Material and Methods: Blood samples of 337 randomly selected children (6-59 months) living in the Ahwaz, Khuzestan province, were taken. Serum ferritin, Complete Blood Cell (CBC) and hematological indices were measured Results and Discussion: In this study 61.1% of the children had serum ferritin less than 12mcg/dl. Prevalence of IDA were 29.1 %. The results showed that most children with IDA were at 12-23 months. Families with more than 6 children had 4.49 times greater chance of IDA. The mean of breast-feeding in non-IDA children was higher than IDA children (17.6 and 16.3 months respectively, P>0.05). In this study families who gave tea to their children for 1-11 months had the highest prevalence of IDA. Conclusion: There are several main risk factors for ID & IDA in the children. Parent's illiteracy, family income and using cow's milk before 12 months are among most important risk factors for iron deficiency for children.
https://ijp.mums.ac.ir/article_2619_a99e9ccebf1439cdd99c0e0173a22d35.pdf
2014-07-01
183
187
10.22038/ijp.2014.2619
Nutrition
Children
Iron deficiency
Anemia
Ali
Ghasemi
ghasemial@mums.ac.ir
1
Assistant professor of Pediatric Hematologist &amp; Oncologist, faculty of medicine, mashhad university of medical sciences
LEAD_AUTHOR
Bijan
Keikhaei
keikhaeib@yahoo.com
2
2) Associate professor of paediatric Haematology Oncology, Ahwaz University of medical sciences (Research centre for thalassemia &hemoglobinopathy).
AUTHOR
1) WHO/ UNICEF/ Iron deficiency anemia : assessment, prevention, and control. A guide for programmed managers. Geneva: World Health Organization (2001).
1
2) Verster A. Guidelines for the control of iron deficiencyin countries of the eastern Mediterranean, Middle East and North Africa. Alexandria, Egypt: World Health Organization, Regional Office for the Eastern Mediterranean 1996 (WHO-EM/NUT/177/E/G/11, 96).
2
3) Hoffbrand AV, Pettit JE, Moss PAH. Essential hematology, 5th ed. Oxford, UK: Blackwell Science, 31-34, 2001.
3
4) Norma B, Sills L, Sills R. Iron deficiency anemia In: Kliegman RM, Stanton BF, Schor NF, Geme JW, Behrman RE, Nelson textbook of pediatrics.19 edition, Elsevier; 2011.p.1565-1566.
4
5) Bahrami M. Malnutrition and its effects on development in Iranian children. J Pediatr Dis 2004; 14:149–56. (article in Persian).
5
6) Hall M.B, Elliman D , Health for all children. 4th ed. Oxford: Oxford University Press , 2003.
6
7) Karimi M, Mirzaei M, Dehghani A. Prevalence of anemia, iron deficiency and iron deficiency anemia in 6–60 month old children in Yazd’s rural area. International
7
Pediatr 2004;19/No3:180–4.
8
8) Heidarnia A, Jalili Z, Dabiri S. The prevalence of iron deficiency anemia in 1–5 years old children referring to Kerman medical care and health centers in 1998.Journal of the Kerman University of Medical Sciences, 1999;6:214–21 (article in Persian).
9
9) Zohouri F., V., Rugg-Gunn A., J. (2002). sources of dietary iron in urban and provincial 4-year –old children in Iran. Asia Pacific J Clin Nutr.11(2):128-132.
10
ORIGINAL_ARTICLE
Pathological evaluation of ganglion cells in biopsies from upper side of the dentate line in patients with perianal problems
Introduction: Constipation is one of the most common complaints of individuals, which may present with complication like hemorrhoid and fissure. Hirschsprung is a disease presenting with chronic constipation and its diagnosis may be delayed until adulthood. It is diagnosed by biopsies from anorectal transitional zone. This study aimed to evaluate the association between Hirschsprung and anorectal problems. Method: Sixty three patients with anorectal problems who underwent surgery enrolled in this study. Some consecutive biopsies were obtained from anal canal at 2, 4 and 6 cm above the dentate line. Biopsies were assessed for ganglion cells changes. Patients' data and biopsies results were analyzed with SPSS version18. Results: Out of 63 patients 29 (46 %) patients were female and 34 (54 %) were male with the mean of 32.65 ± 13.73 years. Fifty six (73 %) patients complained from constipation with the mean time of 57.65 ± 45.21 months. Aganglionic zone were reported in six patients with the mean length of 43.33 mm. There was not any relation between anal ganglion cells pathology and constipation (p=0.363), but there was a significant relation between duration of constipation and pathologic changes (p=0.001). The ratio of constipation duration to age was related to anal ganglion cell pathology (p=0.001). Hemorrhoid degree was also affected anal ganglion cells pathology (p=0.037). Conclusion: The relation between Hirschsprung's disease and anorectal problems in adults were significant. The pathologic findings were more presented in younger patients, and those with longer history of constipation and lower degree hemorrhoids. Key words: Anal ganglion cells, Hemorrhoids, Constipation
https://ijp.mums.ac.ir/article_2775_004db14038eefd3f53ab7f0943ab0523.pdf
2014-07-01
189
193
10.22038/ijp.2014.2775
Anal ganglion cells
Hemorrhoids
Constipation
Marjan
Joudi
joodim@mums.ac.ir
1
Assistant Professor of Surgery, Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences
AUTHOR
Alireza
Sabzevari
sabzevaria@mums.ac.ir
2
Assistant professor of Anesthesiology. Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Nazarzadeh
nazarzadehr1@mums.ac.ir
3
Resident of Fellowship of Pediatric Surgery, Mashhad University of medical sciences. Mashhad, Iran.
AUTHOR
Reza
Sharifi Noghabi
sharifir881@mums.ac.ir
4
4- Resident of General Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Ameri
Leila
ameri.lila@gmail.com
5
5- Resident of Radiology, Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mohsen
Vaziri
ar_sabzevari@yahoo.com
6
Student of medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Amin
Dalili
dalilia881@mums.ac.ir
7
7- Resident of General Surgery, Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Azra
Izanloo
a.izanloo@yahoo.com
8
Msc in Medical Education, Department of Radiology Technology, Faculty of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mehdi
Fathi
mandala_110@yahoo.com
9
Assistant Professor of Anesthesia, Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
1- Brunicardi FC, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, et al.Schwartz’s principles of surgery. 9th ed. New York, McGraw Hil.2010.
1
2- Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, et al. Functional bowel disorders. Gastroenterology 2006; 130: 1480–1491.
2
3- Pinto Sanchez M.I, Bercik P. Epidemiology and burden of chronic constipation. Can J Gastroenterol 2011 October; 25: 11-15.
3
4- Talley NJ. Definitions, epidemiology, and impact of chronic constipation: Rev Gastroenterol Disord 2004; 4 (l 2):3-10.
4
5- Medhi B, Rao RS, Prakash A, Prakash O, Kaman L, Pandhi P. Recent advances in the pharmacotherapy of chronic anal fissure: an update. Asian journal of surgery 2008 Jul ;31(3):154-63.
5
6- Gupta PJ. Internal anal sphincterolysis for chronic anal fissure: a prospective, clinical, and manometric study. American journal of surgery 2007 Jul; 194(1):13-6.
6
7- Boschi L, Lecce F. Two cases of chronic constipation in the adult: Hirschsprung disease and idiopathic megacolon. Minerva chirurgica 1993; 48(12):699-703.
7
8- Campobasso P, Pesce C, Mercurella A, Fabbro MA: Severe chronic constipation. limitations of medical therapy and indications for surgical intervention. II. La Pediatria medica e chirurgica. Medical and surgical pediatrics 1996; 18(5):429-31..
8
9- de Angelis GL, Ghinelli C, Gregori G, Bassani F, Zanacca C, Del Rossi C, et al. Clinical approach to constipation: proposal of a diagnostic and therapeutic protocol. La Pediatria medica e chirurgica. Medical and surgical pediatrics 1983 Sep-Oct; 5(5):381-6.
9
10- Tobias N. Management principles of organic causes of childhood constipation. Journal of pediatric health care 2008 Nov-Dec; 22(6):398.
10
11- Vanoorbeek J, Kint M, Yvergneaux JP. Hirschsprung's disease in adults: the Duhamel procedure. Acta chirurgica Belgica 2004 Jun; 104(3):304-8.
11
12- Vorobyov GI, Achkasov SI, Biryukov OM; Clinical features' diagnostics and treatment of Hirschsprung's disease in adults. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2010 Dec; 12(12):1242-8.
12
13- Kapuller LL, Zhuchenko AP, Achkasov SI, Biriukov OM. The extension of a physiologic hypoganglionic area in adults and its significance in the diagnosis of Hirschprung's disease. Arkhiv patologii 2008 Jan-Feb; 70(1):46-9.
13
14- Koszutski T, Bohosiewicz J, Kudela G, Owczarek K. Diagnostics and treatment of chronic constipation in children--the experience of the department of paediatric surgery. Wiadomosci lekarskie (Warsaw, Poland : 1960) 2004; 57(3-4):193-6.
14
15- Khan AR, Vujanic GM, Huddart S. The constipated child: how likely is Hirschsprung's disease? Pediatr Surg Int 2003 Aug ; 19(6):439-42.
15
16- Monajemzadeh M, Kalantari M, Yaghmai B, Shekarchi R, Mahjoub F, Mehdizadeh M. Hirschsprung's Disease: a Clinical and Pathologic Study in Iranian Constipated Children. Iranian journal of pediatrics 2011 Sep;21(3):362-6.
16
17- Ghosh A, GriYths DM. Rectal biopsy in the investigation of constipation. Arch Dis Child 1998; 79(1):266-8.
17
18- Howard ER, Garrett JR, Kidd A. Constipation and congenital disorders of the myenteric plexus. Journal of the Royal Society of Medicine 1984; 77(3):13-9.
18
ORIGINAL_ARTICLE
The Effectiveness of Acceptance and Commitment Therapy for Children with Chronic Pain (CHACT) on the Function of 7 to 12 Year-Old children
Purpose: The purpose of this study is to evaluate the effect of Acceptance and Commitment Therapy for Children with Chronic Pain (CHACT) on the function of 7 to 12 year-old children. Thus, the basic problem of the current study is whether CHACT can improve the function level of 7 to 12 year-old children with chronic pain? Method: According to the criteria of chronic pain, a number of children with chronic pain were selected by available sampling method from specialty and subspecialty pediatric hospitals of Tehran. Then, among the children, 20 children who according to their parents prepared to participate in this study and met the inclusion criteria, were selected. They were placed in the experimental group (n = 10) and control group (n = 10). The child and parent versions of Function Disability Inventory (FDI) were answered by children and parents in both groups at the pre-test, post-test, first and second follow-up. Result: The result showed that the experimental group compared with the control group showed significant change in function in multiple stages. These changes continued after the treatment, first and secondary follow-up. Conclusion: Regarding the impact of CHACT on the function of children with chronic pain, it can be said that this protocol can be used in clinical fields, especially in the area of improving the function that appears that is one of the most vulnerable areas that children with chronic pain are faced with it.
https://ijp.mums.ac.ir/article_2569_a9f4666c4bf34a1145558b64d711ec3f.pdf
2014-07-01
195
203
10.22038/ijp.2014.2569
Chronic pain
Acceptance
Treatment
Function
Soheila
Ghomian
soheila_ghomian@yahoo.com
1
Shahed University
LEAD_AUTHOR
Mohammad Reza
Shairi
shairigm@yahoo.com
2
Shahed University
AUTHOR
1. Fordyce WE. Behavioral methods for chronic pain and illness . St. Louis: The C.V. Mosby Company. 1976; 3(3):291–292. DOI:10.1016/0304-3959(77)90029-X.
1
2.McCracken LM, Eccleston C. Coping or acceptance: what to do about chronic pain?. Pain. 2003; 105: 197–204.
2
3. Hayes SC, Duckworth MP. Acceptance and Commitment Therapy and Traditional Cognitive Behavior Therapy Approaches to Pain. Cognitive and Behavioral Practice. 2006; 13, 185–187.
3
4. Samwel HJ, Kraaimaat FW, Crul BJ, Evers AW. The role of fearavoidance and helplessness in explaining functional disability in chronic pain: a prospective study. International Journal of Behavioral Medicine. 2007; 14(4): 237-241.
4
5. Crombez G, Vlaeyen JWS, Heuts PHT, Lysens R. Pain-related fear is more disabling then pain itself: evidence on the role of pain-related fear in chronic back pain disability. Pain. 1999;80:329–39.
5
6. Vlaeyen JWS, Kole-Snijders AMJ, Boeren RGB, Van Eek H. Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain. 1995;62:363–72.
6
7. McCracken LM, Carson J W, Eccleston C, Keefe FJ. Acceptance and change in the context of chronic pain. 2004; Pain 109: 4–7.
7
8. Hayes SC, Orsillo SM, Roemer L. Changes in proposed mechanisms of action during an acceptance-based behavior therapy for generalized anxiety disorder. Behaviour Research and Therapy. 2010; 48(3): 238-245.
8
9. Roemer L, Orsillo SM, Salters-Pedneault K. Efficacy of an acceptancebased behavior therapy for generalized anxiety disorder: evaluation in a randomized control trial. Journal of Consulting and Clinical Psychology. 2008; 76(6): 1083-1089.
9
10. Cucciare MA, Sorrell JT, Trafton JA. Predicting response to cognitivebehavioral therapy in a sample of HIV-positive patients with chronic pain. Journal of Behavioral Medicine. 2009; 32(4): 340-348.
10
11. Huggins JL, Bonn-Miller MO, Oser ML, Sorrell JT, Trafton JA. Pain anxiety, acceptance, and outcomes among individuals with HIV and chronic pain: A preliminary investigation. Behaviour Research and Therapy. 2012; 50: 72-78.
11
12. Vowles KE, McNeil DW, Gross RT, McDaniel M, Mouse A, Bates M, Gallimore P, McCall C . Effects of pain acceptance and pain control strategies on physical impairment in individuals with chronic low back pain. Behavior Therapy. 2007; 38: 412–425.
12
13. McCracken LM. Learning to live with the pain: acceptance of pain predicts adjustment in persons with chronic pain. Pain. 1998;74:21–7.
13
14. Wicksell RK, Olsson GL, Hayes SC. Mediators of change in Acceptance and Commitment Therapy for pediatric chronic pain. PAIN. 2011;152: 2792–2801.
14
15. McCracken LM, Eccleston C. A prospective study of acceptance of pain and patient functioning with chronic pain. Pain. 2005; 118: 164-169.
15
16. Vowles KE, McCracken LM. Acceptance and values-based action in chronic pain: a study of treatment effectiveness and process . Journal of Consulting and Clinical Psychology. 2008; 76(3): 397- 407.
16
17.Branstetter-Rost A, Cushing C, Douleh T. Personal Values and Pain Tolerance: Does a Values Intervention Add to Acceptance?. The Journal of Pain. 2009; 10(8): 887-892.
17
18. McCracken LM. Social context and acceptance of chronic pain: the role of solicitous and punishing responses. Pain. 2005; 113: 155–159.
18
19. McCracken LM, Vowles KE .Acceptance of chronic pain. Current Pain and Headache Reports. 2006; 10: 90–94.
19
20. Viane I, Crombez G, Eccleston C, Poppe C, Devulder J, Van Houdenhove B. Acceptance of the unpleasant reality of chronic pain: Effects upon attention to pain and engagement in daily activities. Pain. 2004; 112: 282–288.
20
21. Vowles KE, Wetherell JL, Sorrell JT. Targeting Acceptance, Mindfulness, and Values-Based Action in Chronic Pain: Findings of Two Preliminary Trials of an Outpatient Group-Based Intervention. Cognitive and Behavioral Practice. 2009; 16: 49–58.
21
22. McCracken LM, Spertus IL, Janeck AS, Sinclair D, Wetzel FT. Behavioral dimensions of adjustment in persons with chronic pain: pain-related anxiety and acceptance. Pain. 1999; 80:283–9.
22
23. McCracken LM, Yang S. The role of values in a contextual cognitive-behavioral approach to chronic pain. Pain. 2006; 123: 137–145.
23
24. Dahl J, Wilson KG, Nilsson A. Acceptance and commitment therapy and the treatment of persons at risk for long-term disability resulting from stress and pain symptoms: a preliminary randomized trial. Behav Ther. 2004;35:785–802.
24
25. Wicksell RK, Melin L, Olsson GL. Exposure and acceptance in the rehabilitation of adolescents with idiopathic chronic pain – a pilot study. Eur J Pain. 2007; 11:267–74.
25
26. McCracken LM, Zhao-O’Brien J. General psychological acceptance and chronic pain: There is more to accept than the pain itself. European Journal of Pain. 2010; 14: 170–175.
26
27. Wetherell JL, Afari N, Rutledge T, Sorrell JT, Stoddard JA, Petkus AJ, et al. A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain. PAIN. 2011; 152:2098–2107.
27
28. Hayes SC, Strosahl K, Wilson KG. Acceptance and commitment therapy: An experiential approach to behavior change. New York: The Guilford Press.1999.87.
28
29. McCracken LM, Gutiérrez-Martínez O. Processes of change in psychological flexibility in an interdisciplinary group-based treatment for chronic pain based on Acceptance and Commitment Therapy. Behaviour Research and Therapy. 2011; 49: 267-274.
29
30. Palermo TM. Enhancing daily functioning with exposure and acceptance strategies: An important stride in the development of psychological therapies for pediatric chronic pain. PAIN. 2009; 141:189–190.
30
31. Wicksell RK. Exposure and Acceptance in Patients with Chronic Debilitating Pain - A Behavior Therapy Model to Improve Functioning and Quality of Life. Doctoral Thesis. Karolinska University. Stockholm. Sweden. 2009
31
32. Ghomian S, Shairi MR, Preliminary design of the Acceptance and Commitment Therapy Protocol for Children with Chronic Pain (CHACT) and clinical trial on the degree of psychological inflexibility in pain of children 7 to 12 years old.Journal of Research in Behavioural Sciences. (In Press) [Persian]
32
33. Ghomian S, Shairi MR, Nuri N, Malekzade T. Evaluation of the psychometric properties of Function Disability Inventory (FDI). (In Press)
33
34. Peterson L, Toler S M. An information seeking disposition in child surgery patients. Health Psychology.1986; 5: 343-358.
34
35. Reid GJ, Gilbert CA, McGrath PJ. The pain coping questionnaire: Development and preliminary validation, Manuscript submitted for publication. 1997; 76(1-2):83-96.
35
ORIGINAL_ARTICLE
Evaluation of the Effect of Amino Acid Administration on Hypothermia during General Anesthesia in Hypospadias Surgery on Children Aged 2 to 6 Years
Background: Hypothermia is an important complication during surgery, especially in children and is highly associated with serious adverse outcomes. One of the preventive methods is the intraoperative administration of amino acids, which can be effective through increasing thermogenesis and stimulating energy consumption. No studies have been conducted in this regard on children; therefore, we evaluated the preventive effect of intraoperative administration of amino acid on hypothermia in children. Methods: Forty children, aged 2 to 6 years, who were candidates for hypospadias surgery, were divided into two groups. In the case group, 10% amino acid (2 cc/kg/h) was administered two hours before the operation, and in the control group, normal saline was given as required. All patients underwent a similar method of anesthesia. body temperature was recorded before the anesthesia, immediately after it, and every ten minutes. Results: The mean age and weight had no difference between the groups. Duration of patients' awakening time was 13.60 ± 4.91 min, which in the case and control groups was reported as 11.90 ± 5.27 and 15.30 ± 3.96 min, respectively(p
https://ijp.mums.ac.ir/article_2649_5499111c70879ed9ea8e48572edd388a.pdf
2014-07-01
203
210
10.22038/ijp.2014.2649
amino acid therapy
Hypothermia
General anesthesia
Mohammad
Gharavi fard
gharavim@mums.ac.ir
1
Department of Pediatric Anesthesiology, School of Medicine, Mashhad University of Medical Sciences,Mashhad, Iran
AUTHOR
Arash
Peivandi
peivandia@mums.ac.ir
2
Assistant professor of Anesthesiology. Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Shahram
Amini
aminish@mums.ac.ir
3
Associate Professor of Anesthesiology and Critical Care
Program Director, Anesthesiology Residency
Chief, Division of Critical Care
Department of Anesthesiology
Mashhad University of Medical Sciences
Mashhad, Iran
AUTHOR
Tayebeh beygom
Haji Seyed Abootorabi
n_abootorabi@yahoo.com
4
Resident of Anesthesiology, Department of Anesthesiology
Mashhad University of Medical Sciences
Mashhad, Iran
AUTHOR
Saeed
Bayyenat
5
Assistant Professor of Anesthesiology , Department of Anesthesiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
AUTHOR
Alireza
Sabzevari
sabzevaria@mums.ac.ir
6
Assistant professor of Anesthesiology.Surgical Oncology Research Center,Mashhad University of Medical Sciences
Mashhad, Iran
LEAD_AUTHOR
1. Sellden E, Branstorm R, Brundin T. Preoperative Infusion Of Amino Acids Prevents Postoperative Hypothermia. BrJAnaesth. 1996;76(10):227-34.
1
2. ZHONG J, Sheng-jin G, ZHUANG X, CANG J, Zhang-gang X. Effect of intraoperative amino acids infusion on the metabolism of fat and body temperature in the patients undergoing gastrointestinal surgery. Anesthesia. 2011;04(11):101.
2
3. Kamitani K, Yoshida H, Takagi M, Minami M, Tokutake M, Kishi R, et al. [Effect of amino acid infusion for prevention of intraoperative hypothermia during laparotomy]. Masui The Japanese journal of anesthesiology. 2006 Oct;55(10):1216-21. PubMed PMID: 17051978. Epub 2006/10/21. jpn.
3
4. Moriyama T, Tsuneyoshi I, Omae T, Takeyama M, Kanmura Y. The effect of amino-acid infusion during off-pump coronary arterial bypass surgery on thermogenic and hormonal regulation. Journal of anesthesia. 2008;22(4):354-60. PubMed PMID: 19011772. Epub 2008/11/18. eng.
4
5. Sellden E, Brundin T, Wahren J. Augmented thermic effect of amino acids under general anaesthesia: a mechanism useful for prevention of anaesthesia-induced hypothermia. Clinical science (London, England : 1979). 1994 May;86(5):611-8. PubMed PMID: 8033514. Epub 1994/05/01. eng.
5
6. Inoue S, Shinjo T, Kawaguchi M, Nakajima Y, Furuya H. Amino acid infusions started after development of intraoperative core hypothermia do not affect rewarming but reduce the incidence of postoperative shivering during major abdominal surgery: a randomized trial. Journal of anesthesia. 2011 Dec;25(6):850-4. PubMed PMID: 21927856. Epub 2011/09/20. eng.
6
7. Yamaoka I, Doi M, Nakayama M, Ozeki A, Mochizuki S, Sugahara K, et al. Intravenous administration of amino acids during anesthesia stimulates muscle protein synthesis and heat accumulation in the body. American journal of physiology Endocrinology and metabolism. 2006 May;290(5):E882-8. PubMed PMID: 16352675. Epub 2005/12/15. eng.
7
8. Sellden E. Peri-operative amino acid administration and the metabolic response to surgery. The Proceedings of the Nutrition Society. 2002 Aug;61(3):337-43. PubMed PMID: 12296293. Epub 2002/09/26. eng.
8
9. Sellden E, Lindahl SG. Amino acid-induced thermogenesis reduces hypothermia during anesthesia and shortens hospital stay. Anesth Analg. 1999 Dec;89(6):1551-6. PubMed PMID: 10589647. Epub 1999/12/10. eng.
9
10. Zeba S, Surbatovic M, Jevtic M, Filipovic N, Popovic N, Radakovic S, et al. [Influence of perioperative administration of amino acids on thermoregulation response in patients underwent colorectal surgical procedures]. Vojnosanitetski pregled Military-medical and pharmaceutical review. 2007 Jun;64(6):421-4. PubMed PMID: 17687949. Epub 2007/08/11. srp.
10
11. Sahin A, Aypar U. Effect of amino acid solutions on intraoperative hypothermia and postoperative shivering. Comparison of two anesthetic regimens. Acta anaesthesiologica Scandinavica. 2002 Jan;46(1):64-7. PubMed PMID: 11903074. Epub 2002/03/21. eng.
11
12. Sellden E, Lindahl SG. Postoperative nitrogen excretion after amino acid-induced thermogenesis under anesthesia. Anesth Analg. 1998 Sep;87(3):641-6. PubMed PMID: 9728846. Epub 1998/09/05. eng.
12
13. Sellden E, Sten GE, Lindahl. Amino Acid-Induced Thermogenesis Reduces Hypothermia During Anesthesia and Shortens Hospital Stay. Anesth Analg. 1999;89(10):1551-6.
13
14. Sellden E, Lindahl SG. Amino acid-induced thermogenesis to prevent hypothermia during anesthesia is not associated with increased stress response. Anesth Analg. 1998 Sep;87(3):637-40. PubMed PMID: 9728845. Epub 1998/09/05. eng.
14
15. Sellden E. [Amino acid administration counteracts hypothermia during anesthesia]. Lakartidningen. 2001 Apr 4;98(14):1664-9. PubMed PMID: 11379167. Epub 2001/05/31. Aminosyretillforsel motverkar hypotermi under anestesi. swe.
15
16. Chandrasekaran TV, Morgan RN, Mason RA, Mangat PS, Watkins AJ, Carr ND. Nutrient induced thermogenesis during major colorectal excision--a pilot study. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2005 Jan;7(1):74-8. PubMed PMID: 15606590. Epub 2004/12/21. eng.
16
17. Kamitani K, Higuchi A, Nohara A, Takagi M, Tokutake M, Horikawa H, et al. [Effect of amino acid solution on intraoperative core temperature the influence of anesthetics]. Masui The Japanese journal of anesthesiology. 2005 Nov;54(11):1258-62. PubMed PMID: 16296364. Epub 2005/11/22. jpn.
17
18. Mizobe T, Nakajima Y. [Dietary-induced thermogenesis and perioperative thermoregulation]. Masui The Japanese journal of anesthesiology. 2007 Mar;56(3):305-16. PubMed PMID: 17366918. Epub 2007/03/21. jpn.
18
ORIGINAL_ARTICLE
Spinal Muscular Atrophy: A Short Review Article
Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory failure, symmetric muscle atrophy and paralysis in patients with SMA. Manifestations are prominent in proximal muscle of lower extremities. There is no curative treatment for spinal muscular atrophy, and supportive treatment should be considered to improve patients’ quality of life and independency. New treatment strategies focus on gene therapy or invent method to increase survival motor neuron protein level. The aim of this study is to review Spinal muscular atrophy (SMA) clinical and molecular manifestations.
https://ijp.mums.ac.ir/article_2570_e68bd26dfc9a3db7c165a8f0ce22d993.pdf
2014-07-01
211
215
10.22038/ijp.2014.2570
Molecular analysis
Spinal muscular atrophy
Survival motor neuron protein
Farah
Ashrafzadeh
ashrafzadehf@mums.ac.ir
1
Professor of Pediatric Neurology Ward, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Ariane
Sadr-Nabavi
2
Assistant Professor of Human Genetic, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Nazanin
Asadian
3
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Javad
Akhondian
akhondianj@mums.ac.ir
4
Professor of Pediatric Neurology Ward, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mehran
Beiraghi Toosi
beiraghitm@mums.ac.ir
5
Assistant Professor of Pediatric Neurology Ward, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Fraidakis MJ, Drunat S, Maisonobe T, Gerard B, Pradat PF, Meininger V et al. Genotype-phenotype relationship in 2 SMA III patients with novel mutations in the Tudor domain. Neurology. 2012 Feb 21;78(8):551-6. doi: 10.1212/WNL.0b013e318247ca69. Epub 2012 Feb 8.
1
He J, Zhang QJ, Lin QF, Chen YF, Lin XZ, Lin MT et al. Molecular analysis of SMN1, SMN2, NAIP, GTF2H2, and H4F5 genes in 157 Chinese patients with spinal muscular atrophy. Gene. 2013 Apr 15;518(2):325-9. doi: 10.1016/j.gene.2012.12.109. Epub 2013 Jan 23.
2
Wong VC, Chung BH, Li S, Goh W, Lee SL. Mutation of gene in spinal muscular atrophy respiratory distress type 1. Pediatr Neurol 2006;34:474–7.
3
AlSaman A, Tomoum H. Infantile spinal muscular atrophy with respirtory distress type 1: a case report. J Child Neurol 2010;25:764–9.
4
Kuźma-Kozakiewicz M, Jędrzejowska M, Kaźmierczak B. SMN1 gene duplications are more frequent in patients with progressive muscular atrophy. Amyotroph Lateral Scler Frontotemporal Degener. 2013 Sep;14(5-6):457-62. doi: 10.3109/21678421.2013.771367. Epub 2013 Mar 12.
5
Majid A, Talat K, Colin L, Caroline R, Helen K, Christian de G. Heterogeneity in spinal muscular atrophy with respiratory distress type 1. J Pediatr Neurosci. 2012 Sep;7(3):197-9. doi: 10.4103/1817-1745.106478.
6
Martinez TL, Kong L, Wang X, Osborne MA, Crowder ME, Van Meerbeke JP et al. Survival motor neuron protein in motor neurons determines synaptic integrity in spinal muscular atrophy. J Neurosci. 2012 Jun 20;32(25):8703-15. doi: 10.1523/JNEUROSCI.0204-12.2012.
7
Omrani O, Bonyadi M, Barzgar M. Molecular analysis of the SMN and NAIP genes in Iranian spinal muscular atrophy patients. Pediatr Int. 2009 Apr;51(2):193-6. doi: 10.1111/j.1442-200X.2008.02665.x.
8
Derakhshandeh-Peykar P, Esmaili M, Ousati-Ashtiani Z, Rahmani M, Babrzadeh F, Farshidi S et al. Molecular analysis of the SMN1 and NAIP genes in Iranian patients with spinal muscular atrophy. Ann Acad Med Singapore. 2007 Nov;36(11):937-41.
9
Nguyen DB, Sadewa AH, Takeshima Y, Sutomo R, Tran VK, Nguyen TN, et al. Deletion of the SMN1 and NAIP genes in Vietnamese patients with spinal muscular atrophy. Kobe J Med Sci 2003;49:55-8.
10
Wang YY, Feng SW, Cao JQ, Yang J, Li YQ, Li J, Zhang C. [Genotypic and clinical features of spinal muscular atrophy type 3]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012 Apr;29(2):218-21. doi: 10.3760/cma.j.issn.1003-9406.2012.02.022. [Article in Chinese]
11
Harada Y, Sutomo R, Sadewa AH, Akutsu T, Takeshima Y, Wada H et al. Correlation between SMN2 copy number and clinical phenotype of spinal muscular atrophy: three SMN2 copies fail to rescue some patients from the disease severity. J Neurol. 2002 Sep;249(9):1211-9.
12
Watihayati MS, Fatemeh H, Marini M, Atif AB, Zahiruddin WM, Sasongko TH et al. Combination of SMN2 copy number and NAIP deletion predicts disease severity in spinal muscular atrophy. Brain Dev. 2009 Jan;31(1):42-5. doi: 10.1016/j.braindev.2008.08.012. Epub 2008 Oct 7.
13
Miskovic M, Lalic T, Radivojevic D, Cirkovic S, Vlahovic G, Zamurovic D et al. Lower incidence of deletions in the survival of motor neuron gene and the neuronal apoptosis inhibitory protein gene in children with spinal muscular atrophy from Serbia. Tohoku J Exp Med. 2011;225(3):153-9.
14
Liu WL, Li F, He ZX, Ai R, Ma HW. Molecular analysis of the SMN gene mutations in spinal muscular atrophy patients in China. Genet Mol Res. 2013 Sep 13;12(3):3598-604. doi: 10.4238/2013.September.13.4.
15
He J, Zhang QJ, Lin QF, Chen YF, Lin XZ, Lin MT et al. Molecular analysis of SMN1, SMN2, NAIP, GTF2H2, and H4F5 genes in 157 Chinese patients with spinal muscular atrophy. Gene. 2013 Apr 15;518(2):325-9. doi: 10.1016/j.gene.2012.12.109. Epub 2013 Jan 23.
16
Piepers s, Cobben J, Sodaar P, Jansen M, Wadman R, Meester-Delver A. Quantification of SMN protein in leucocytes from spinal muscular atrophy patients: effects of treatment with valproic acid. J Neurol Neurosurg Psychiatry 2011;82:850e852. doi:10.1136/jnnp.2009.200253
17
Tiziano FD, Lomastro R, Di Pietro L, Barbara Pasanisi M, Fiori S, et al. Clinical and molecular cross-sectional study of a cohort of adult type III spinal muscular atrophy patients: clues from a biomarker study. Eur J Hum Genet. 2013;21(6):630-6. doi: 10.1038/ejhg.2012.233. Epub 2012 Oct 17.
18
ORIGINAL_ARTICLE
Bilateral Spontaneous Hemothorax with PNET: a case report and review
Background: Neuroectodermal Tumors (PNET) are malignant small cells neoplasm mainly occurring in children but can occur at any age. Extensive bleeding into the pleural cavity is rare In Children. Hemothorax would be compatible with a variety of congenital anomalies including sequestration, patent ductus artreiosus, and pulmonary arteriovenous malformation. Case report: A 2.5-years old girl who was known a case of PNET with dyspnea and tachypnea referred to our hospital. The chest X-ray revealed bilateral opacity. After consulting the general surgeon, the bilateral chest-tubes inserted and 200cc blood drained. Discussion: The diagnosis of a hemothorax can be made only by thoracentesis. The symptomatology of the Peripheral Primitive Neuroectodermal Tumors is related to size and their location. We did not find any residue of cancer as a cause of hemothorax, and the hemothorax was not related to side effects of chemotherapy, infection and trauma. Therefore, PNET should be included as a cause of children hemothorax.
https://ijp.mums.ac.ir/article_2620_22a4a37ce0c47e5b1fd3e6dd43fadd95.pdf
2014-07-01
217
219
10.22038/ijp.2014.2620
PNET
Bilateral Spontaneous
Hemothorax
Ali
Ghasemi
ghasemial@mums.ac.ir
1
Assistant professor of Pediatric Hematologist &amp; Oncologist, faculty of medicine, mashhad university of medical sciences
LEAD_AUTHOR
Bijan
Keikhaee
keikhaeib@yahoo.com
2
2) Associate professor of hematology and oncology, Jondishapour University of Medical Sciences, Ahvaz, (research center for thalassemia and hemoglobinopathy).
AUTHOR
1) Chana amir B& Hussein Altaf. Spontaneous hemothrax: report of two unique cases. Internal J of anesthiology.2005; volume9, number2.
1
2) Pizzo P.A, Poplack D.G, Principles and practice of pediatric oncology 5edition 2005 p: 1002-1027.
2
3) Ambros IM, Ambros PF, Strehl S, et al: MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing’s sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67 (7): 1886-93, 1991.
3
4) Delattre O, Zucman J, Melot T, et al: The Ewing’s family of tumors—a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl JMed 331 (5): 294-9, 1994.
4
5) Behrman RE, klieg man RM, jenson HB, nelson textbook of pediatrics 17edition P: 1465-1466.
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6) kepes JJ, Morantz RA, Dorzab WE. cerebellar meduloblastoma in 73 years old voman.Neurosurgery.1987;21:81-3.
6
7) Horwich A: a multidisciplinary textbook of oncology first edition1995:page;405.
7
8) Sweetman SC. et al. the complete drug reference. Martindale. 33rd edition 2002, p527-579.
8
9) Daralane C …et al, Nursing drug references mosby,s 2006.
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