TY - JOUR ID - 13735 TI - Macrophage Activation Syndrome as the First Impression of Kawasaki Disease; A Case Report JO - International Journal of Pediatrics JA - IJP LA - en SN - 2345-5047 AU - Ahmadzadeh Amiri, Ali AU - Sadeghi, Payman AU - Mousavi Torshizi, Mahdieh AD - Department of Pediatric Rheumatology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran. Y1 - 2019 PY - 2019 VL - 7 IS - 12 SP - 10449 EP - 10454 KW - Children KW - Iran KW - Macrophage activation syndrome KW - Kawasaki disease DO - 10.22038/ijp.2019.41877.3529 N2 - Introduction Macrophage activation syndrome (MAS) is a rare and life-threatening complication of Kawasaki Disease (KD) that is usually diagnosed at the same time or after KD. We report a case of MAS as the initial manifestation of KD. Case Report A previously healthy 3-year old girl was admitted to the pediatric infectious diseases ward of Bahrami Children’s Hospital, Tehran, Iran. She had a 3-day history of fever and lymphadenopathy which persisted despite antibiotic therapy. Patient's general condition gradually worsened and she developed loss of consciousness. After being diagnosed with MAS based on laboratory findings, she developed mucocutaneous manifestations of KD. She responded to methylprednisolone pulse therapy, intravenous immunoglobulin and dipyridamole. The follow-up at 2 weeks and 2 months showed no abnormal findings. Conclusion MAS may manifest even before the diagnosis of KD is made.  Early recognition of MAS associated with KD and prompt treatment with corticosteroids can improve the outcome. UR - https://ijp.mums.ac.ir/article_13735.html L1 - https://ijp.mums.ac.ir/article_13735_899ad3c5310565d98ac29df53479f753.pdf ER -