TY - JOUR ID - 7812 TI - The Effect of Melatonin on Pediatric Drug-Resistant Epilepsy; a Randomized Double Blind Clinical Trial JO - International Journal of Pediatrics JA - IJP LA - en SN - 2345-5047 AU - Akhondian, Javad AU - Beiraghi Toosi, Mehran AU - Kianifar, Hamidreza AU - Talebi, Saeedeh AU - Ghanaei, Omid AD - Professor, Pediatric Neurologist, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Mashhad university of medical sciences AD - Pediatrician, Pediatric Researcher, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Adult Gastroenterologist, Gastroenterology and Hepatology Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2016 PY - 2016 VL - 4 IS - 11 SP - 3897 EP - 3906 KW - Children KW - Intractable seizure KW - Melatonin DO - 10.22038/ijp.2016.7812 N2 - BackgroundAbout 15 to 40% of children with seizures are refractory to standard anti-epileptic drugs and for such patients, other treatments such as surgery and the ketogenic diet can reduce seizure frequency. Melatonin is a natural pineal gland hormone. The use of melatonin for controlling pediatric seizures is still controversial. This study aimed to evaluate the effect of melatonin on seizures, parent's satisfaction, sleep, and behavior in children with drug-resistant epilepsy.Materials and Methods: In a pilot crossover study, children with drug-resistant epilepsy, who referred to the epileptic clinic of Ghaem Hospital, were randomly assigned to receive treatment with melatonin or a placebo for 4 weeks followed by a one-day washout period. Then patients who started with melatonin were switched to the placebo. Melatonin was administered 30 minutes before bedtime at a dose of 10 mg /m2 in 3mg tablets.ResultsTwenty patients, of which 11 (55%) were male, were enrolled into the study. The range and mean age of patients were 2 to 13 years and 7.28 ± 3.46 years, respectively. The mean number of diurnal seizures in the study group during placebo treatment was 11.05 and during melatonin treatment was 6.25, which was statistically significant (P=0.021). However, the reduction of the mean duration of diurnal seizures in the study groups was not statistically significant (P=0.386). There was no correlation between decreasing in number or duration of seizures with melatonin plasma levels. Drowsiness was the only side effect of melatonin, which occurred in three patients. ConclusionMelatonin has probable beneficial effects on some epileptic patients with unclear mechanisms. Physicians can use it in selected epileptic children to improve seizures. UR - https://ijp.mums.ac.ir/article_7812.html L1 - https://ijp.mums.ac.ir/article_7812_67f57b86ace76d0a6ff38c9c50674139.pdf ER -