Comparison of Restricted Fluid Volume with Standard Fluid Volume in Management of Transient Tachypnea of the Newborns: A Randomized Controlled Trial

Authors

1 Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, IR Iran.

2 Department of Epidemiology, School of Public Health,Hamadan University of Medical Sciences, Hamadan, IR Iran.

3 Department of Perinatology, Tehran University of Medical Sciences, Tehran, IR Iran.

Abstract

Background
Transient tachypnea of the newborn (TTN) is one of the most common neonatal respiratory disease and its symptoms usually begins in the first few hours after birth. The volume of fluid intake according to the neonate's conditions varies. We aimed to compare the restricted fluids volume with standard fluids volume in treatment of neonates with TTN.
Materials and Methods: This clinical trial was performed on 80 neonates with a diagnosis of TTN admitted in the Neonatal intensive care unit (NICU) of Fatemiyeh Hospital and Beasat Hospital of Hamadan Medical University in Iran. Patients were randomly divided to standard fluids volume (control = 40), and restricted fluids volume treatment groups (case = 40). The hospitalization duration, oxygen therapy duration as well as the number of days need for oxygen with hood; Nasal continuous positive airway pressure (NCPAP), and mechanical ventilation therapy was recorded. After data collection, the data were statistically analyzed via SPSS software (version 21.0).
Results: The subjects were 30 (37.5%) females and 50 (62.5%) males (62.5%) with an average gestational age of 38.12(±1.07) weeks.The main aim from this interventional study was effect of restricted fluidtherapy on management of TTN in NICU section. The hospitalization duration, oxygen therapy duration and need for oxygen therapy with hood in the intervention group were significantly lower than the control group (P<0.05), but need for mechanical ventilation and need for NCPAP were not significantly different between the two groups (P>0.05).
Conclusion
TTN treatment with restricted fluids volume, compared with standard volume of fluids, significantly reduces the need for respiratory supports as well as the duration of hospitalization in the NICU section.

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