Effects of Fasting on Glucagon-like peptide-1 hormone (GLP-1), and Lipid Profile Indices in Obese and Thin Women


1 Department of Biochemistry, Payame Noor University, Mashhad, Iran.

2 Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

3 Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 PhD in Laboratory Science, Mashhad, Iran.


Introduction: Glucagon-like peptide-1 hormone (GLP-1) contributes to the regulation of insulin and glucose concentration. However, the effects of fasting on GLP-1 response in different people has not been determined yet. The aim of the present research was to investigate the effect of fasting on GLP-1 and the lipid profile of obese and thin women.
Materials and methods: In this research, 25 obese and thin women whose age ranged from 35 to 45 years were selected through a convenient sampling method and were divided into two groups of obese (n=12, body mass index ˃30 kg/m2) and thin (n=13, body mass index=18-20 kg/m2). GLP-1 in both groups was measured in four phases: 3 days before the beginning of Ramadan, 14 days after the beginning of Ramadan, 28 days after the beginning of Ramadan and 2 weeks after the end of Ramadan. Repeated –measure ANOVA was used to statistically analyse the data.
Results: GLP-1 was reduced from phase 1 to 3 of the research. However, it was increased after Ramadan. In the thin group, GLP-1 was increased in 14 days of fasting, but did not show any change at the end of Ramadan, and also two weeks after this month. However, none of these changes were statistically significant. The two groups did not diverge from each other significantly in any of the phases.
Conclusion: The present findings showed that fasting has no significant effect on the GLP-1 and lipid profile indices of the obese and thin women.