Mozaffari Khosravi, H., Hojjati Kermani, M., Hassanzad, M., Rezaie, M., Tashayoie-Nejad, S., Sayedi, S., Velayati, A. (2019). Effects of Coenzyme Q10 Level on Clinical Parameters in Cystic Fibrosis Patients. International Journal of Pediatrics, 7(4), 9285-9294. doi: 10.22038/ijp.2018.36053.3145
Hassan Mozaffari Khosravi; Mohammad Ali Hojjati Kermani; Maryam Hassanzad; Mansour Rezaie; Sabereh Tashayoie-Nejad; Seyed Javad Sayedi; Ali Akbar Velayati. "Effects of Coenzyme Q10 Level on Clinical Parameters in Cystic Fibrosis Patients". International Journal of Pediatrics, 7, 4, 2019, 9285-9294. doi: 10.22038/ijp.2018.36053.3145
Mozaffari Khosravi, H., Hojjati Kermani, M., Hassanzad, M., Rezaie, M., Tashayoie-Nejad, S., Sayedi, S., Velayati, A. (2019). 'Effects of Coenzyme Q10 Level on Clinical Parameters in Cystic Fibrosis Patients', International Journal of Pediatrics, 7(4), pp. 9285-9294. doi: 10.22038/ijp.2018.36053.3145
Mozaffari Khosravi, H., Hojjati Kermani, M., Hassanzad, M., Rezaie, M., Tashayoie-Nejad, S., Sayedi, S., Velayati, A. Effects of Coenzyme Q10 Level on Clinical Parameters in Cystic Fibrosis Patients. International Journal of Pediatrics, 2019; 7(4): 9285-9294. doi: 10.22038/ijp.2018.36053.3145
Effects of Coenzyme Q10 Level on Clinical Parameters in Cystic Fibrosis Patients
1Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
2Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Chronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
4Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
5Mycobacteriology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract
Background: Cystic Fibrosis (CF) is a hereditary autosomal recessive genetic disorder that can affect many organs including the lungs and the digestive system. We aimed to assess the effects of coenzyme Q10 level on clinical parameters in cystic fibrosis patients. Materials and Methods This cross-sectional study was performed on 40 patients (13 females and 19 males) with cystic fibrosis who were admitted in Masih Daneshvari Hospital in Tehran- Iran, in 2017. A researcher-made questionnaire was distributed among them, and then the height, weight and arm circumference of the patients were measured and also their serum Q10 levels were evaluated. Then, the pulmonary function was evaluated using a 6-minute respiration test and a spirometry test. Finally, their total scores were calculated based on Shwachman score. Results: The age range of participants was from 6 to 27 years old. Anthropometric indices such as weight (p=0.02, r=-0.408), age (p=0.016, r=-0.422), height (p=0.002, r=-0.520), birth weight (p=0.0113, R=-0.286), and height at birth (p=0.037, r=-0.37) had a significant negative relationship with coenzyme Q10. There was relationship between anthropometric indices and spirometry tests, including the association of FEV1 (act) with weight (p=0.00), and arm circumference (p=0.00) which were determined. Conclusion: According to the results, there was no direct relationship between muscle mass and Q10. Besides, the mean age of Q10 was greater than that of in age group of 9-16 years old, which can be considered for nutrition or childhood reserves for coenzyme Q10 production, which is decreased due to increasing age and lack of intake or loss of body power for the production of coenzyme Q10.
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