An Overview of Prophylactic Acetylsalicylic Acid for the Prevention of Intra-uterine Growth Restriction (IUGR) in Women

Authors

1 Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Head and Neck Research Center, Facial Plastic Surgery Division, Tehran University of Medical Science, Tehran, Iran.

3 General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Fellowship of Neonatology, Department of pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

6 Department of Midwifery, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.

Abstract

Objective: Preeclampsia is a major global cause of maternal, neonatal and perinatal mortality. The aim of this review was to summarize all reviews on Acetylsalicylic Acid for the prevention of Intra-uterine Growth Restriction (IUGR) in women at risk for Preeclampsia.

Material and methods: We searched databases following MEDLINE, SCOPUS, EMBASE, Central Records Central Register Cochrane and the Web of Science databases for finding relate articles regarding Acetylsalicylic Acid on the prevention of Intra-uterine Growth Restriction (IUGR) in Women at high risk for Preeclampsia. Search conducted from 1996 to 5 April 2019 with English keywords. Any meta-analysis, published or unpublished, was eligible for inclusion. No language restriction was imposed.

Results: Seven meta-analysis were included into reviewed. Acetylsalicylic Acid began at 16 ≤ weeks significantly reduced IUGR in women; but it was not effective in the subgroups of women who took acetylsalicylic Acid when they had gestational age of more than 16 weeks. One meta-analysis showed that Acetylsalicylic Acid were superior to control group in decreasing of IUGR in East Asians (OR=0.36). While, any significant effectiveness were not in non-East Asians (OR = 0.85). According to one meta-analysis, a dose-response effect of Acetylsalicylic Acid (p=0.04) on IUGR were observed if Acetylsalicylic Acid began at 16 ≤weeks. However, a dose-response effect (p= 0.95) were not seen if women started when they were in gestational age more than 16 weeks.

Keywords