Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Head and Neck Research Center, Facial Plastic Surgery Division, Tehran University of Medical Science, Tehran, Iran.
General Physician, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmacy School, Mashhad University of Medical Sciences, Mashhad, Iran.
Fellowship of Neonatology, Department of pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Midwifery, Firoozabad Branch, Islamic Azad University, Firoozabad, Iran.
Objective: Preeclampsia is a major global cause of maternal, neonatal and perinatal mortality. The aim of this review was to summarize all reviews on Acetylsalicylic Acid for the prevention of Intra-uterine Growth Restriction (IUGR) in women at risk for Preeclampsia.
Material and methods: We searched databases following MEDLINE, SCOPUS, EMBASE, Central Records Central Register Cochrane and the Web of Science databases for finding relate articles regarding Acetylsalicylic Acid on the prevention of Intra-uterine Growth Restriction (IUGR) in Women at high risk for Preeclampsia. Search conducted from 1996 to 5 April 2019 with English keywords. Any meta-analysis, published or unpublished, was eligible for inclusion. No language restriction was imposed.
Results: Seven meta-analysis were included into reviewed. Acetylsalicylic Acid began at 16 ≤ weeks significantly reduced IUGR in women; but it was not effective in the subgroups of women who took acetylsalicylic Acid when they had gestational age of more than 16 weeks. One meta-analysis showed that Acetylsalicylic Acid were superior to control group in decreasing of IUGR in East Asians (OR=0.36). While, any significant effectiveness were not in non-East Asians (OR = 0.85). According to one meta-analysis, a dose-response effect of Acetylsalicylic Acid (p=0.04) on IUGR were observed if Acetylsalicylic Acid began at 16 ≤weeks. However, a dose-response effect (p= 0.95) were not seen if women started when they were in gestational age more than 16 weeks.