Professor of Pediatrics, Department of Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran
Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, Iran
Student Research Commite, Iran University of Medical Science, Tehran, Iran
Fellowship of Hematology and Oncology, Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
Background: One of the major adverse effect of chemotherapy is chemotherapy induced nausea and vomiting (CINV) which can obviously reduce patients’ quality of life. Ginger, an herbal supplement, have been using for centuries for gastrointestinal complaints. Although many surveys conducted to find the efficiency of ginger on CINV, its benefit hasn’t proven yet. The aim of this present study was to find ginger’s efficiency on pediatric patients throughout their chemotherapy cycles.
Patients and methods: This was a double-blinded, randomized, single institutional, placebo-controlled trial conducted at oncology ward in an academic children hospital. We included 49 chemotherapy cycles, 25 cycles for treatment group and 24 cycles for placebo groups. Intervention group took encapsulated ginger which contained 240mg powder of ginger (Nausophar) and control group took placebo. Frequency and severity of nausea and vomiting were measured by Edmonton’s Symptom Assessment Scale (ESAS) from the first day of chemotherapy until 24h after completion of chemotherapy.
Results: There were no significant differences in distribution of patients’ characteristic in two groups. The frequency and severity of nausea and vomiting were significantly lower in ginger group (p