The Some Predictive Factors for Survival of Newborns with Esophageal Atresia

Authors

1 Department of Neonatology, Bahrami children’s Hospital, Tehran University of Medical Science, Tehran, Iran.

2 Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatric, Bahrami children’s Hospital, Tehran University of Medical Science, Tehran, Iran.

3 Department of Pediatric Intensive Care Unit, Bahrami Children’s Hospital, Tehran University of Medical Science, Tehran, Iran.

Abstract

Background: The esophageal atresia (EA) is the most common esophageal congenital anomaly. The aim of this study was to evaluate the predictive factors in the survival of newborns with esophageal atresia.
Methods: This was a descriptive-analytic cross-sectional study performed on newborns with esophageal atresia who were admitted at Bahrami children’s hospital, Tehran-Iran, during 7 years (2009-2015). The patient’s information was recorded in a checklist. The variables of the checklist included: age, sex, gestational age, birth weight, congenital anomalies, duration of mechanical ventilation, duration of hospitalization, respiratory distress syndrome (RDS), age at surgery, complications and cause of death. Then, the relationship between different variables evaluated with mortality and morbidity and identified the factors that had the greatest impact on patients' prognosis.
Results: The study included 95 neonates with EA. Fifty-three (55.8%) were male. The most common anomalies were cardiac(38.9%), renal(15.8%), and skeletal(9.5%). The most common postoperative complication was pneumothorax(31.6%), pneumonia(25%), and stenosis at the site of anastomosis(21.1%). In this study, 15 children died (mortality rate 15.7%), and the most common cause was sepsis. There was a significant relationship between birth weight and death, pneumothorax (P-value = 0.008, 0.037, respectively). There was no significant relationship between gestational age and mortality (P-value >0.05). There was a significant relationship between major cardiac anomalies and duration of mechanical ventilation and mortality (P-value = 0.043, p

Keywords