The effect of vitamin E on cisplatin induced nephrotoxicity Clinical trial

Authors

1 Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Associate Professor of Pediatrics Oncology, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Associate Professor, Hematologist and Oncologist, Montaserie Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Kidney Transplantation Complication Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Department of Community Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Abstract

Background: cisplatin is platinum based chemotherapy drug that is commonly used for the treatment of the solid tumors. It is believed that this drug has nephrotoxic effects due to its oxidative action. Therefore, it is believed antioxidant agents such as vitamin E can prevent this nephrotoxic effect; however, no human study is conducted till now.
Aim: to assess the nephroprotective effects of vitamin E against cisplatin nephrotoxicity.
Method and materials: in a clinical trial, the patients were grouped into two control and intervention group. Both groups should receive cisplatin with a dose of 50 mg/m2 as single dose or in 3 to 5 divided doses. The intervention group received 400 IU of vitamin E daily until two days after discontinuing cisplatin and the control group received placebo. Patients’ serum urea, creatinine, and KIM-1 marker levels were measured and compared between the two study groups and in a before-after manner.
Result: Totally, 29 patients were grouped into 17 controls and 12 cases. Although the KIM marker was significantly higher in intervention group (p=0.002), it was statistically higher in control group at the end of study (p=0.021). Urea was also significantly higher in the control group before and after vitamin E administration (p<0.0001). When assessing the before-after results, KIM marker showed a significant decrease (1.09±0 to 0±0.09; p<0.0001); however, creatinine serum level significantly rose (0±0 to 1.09±0; p<0.0001).
Conclusion: it seems vitamin E can help to protect kidney against cisplatin toxicity; however, further clinical trials are needed to support our findings.

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