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The effect of Maternal Vitamin D Deficiency on Increased Risk for Hyperbilirubinemia in Term Newborns

Authors

1 Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Abstract

Background
Neonatal jaundice is prevalent, and the presence of hyperbilirubinemia frequently requires medical attention and hospital readmission. The aim of the present study was to determine the effect of maternal vitamin D deficiency on increased risk for hyperbilirubinemia in term newborns.
Materials and Methods
This cross-sectional study was conducted on all pregnant women with gestational age of 38-42 weeks from southwestern Iran who referred to Hafez Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran, from March 2018 to August 2018. Serum 25-hydroxyvitamin D was measured from 300 included pregnant women during birth time. The level of bilirubin was measured in their newborns at 3rd to 5th days of life. The obtained data were analyzed using SPSS software version 22.0.
Results
The level of 25-hydroxyvitamin D was low in 277 (92.3%) pregnant women. Hyperbilirubinemia was detected in 38 (12.6%) newborns at the 3rd to 5th days of life. Maternal vitamin D during pregnancy showed a significant correlation with the levels of bilirubin in newborns (r= - 0.458, P<0.001). 
Conclusion
The results of this study showed that maternal vitamin D deficiency could be associated with the increased risk for neonatal hyperbilirubinemia.

Keywords

References
  1. Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in Neonates: Types, Causes, Clinical Examinations, Preventive Measures and Treatments: A Narrative Review Article. Iran J Public Health. 2016; 45(5):558-68.
  2. Allen D. Neonatal jaundice. Nurs Child Young People. 2016; 8; 28(6):11.
  3. Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 1999; 103:6e14.
  4. Mojtahedi SY, Izadi A, Seirafi G, Khedmat L, Tavakolizadeh R. Risk Factors Associated with Neonatal Jaundice: A Cross-Sectional Study from Iran. Open Access Maced J Med Sci. 2018; 11; 6(8):1387-93.
  5. Olusanya BO, Kaplan M, Hansen TWR. Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health. 2018; 2(8):610-20.
  6. Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002; 15; 65(4):599-606.
  7. Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, et al. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. Afr J Prim Health Care Fam Med. 2018; 10(1):e1-e6.
  8. Kirk JM. Neonatal jaundice: a critical review of the role and practice of bilirubin analysis. Ann Clin Biochem. 2008; 45(Pt 5):452-62.
  9. Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011; 86(1):50-60.
  10. Abbasian M, Chaman R, Amiri M, et al. Vitamin D deficiency in pregnant women and their neonates. Glob J Health Sci. 2016; 8(9): 83–90.
  11. Kozeta Miliku, Anna Vinkhuyzen, Laura M. E. Blanken, John J. McGrath, Darryl W. Eyles, Thomas H. Burne, et al. Maternal vitamin D concentrations during pregnancy, fetal growth patterns and risks of adverse birth outcomes. Am J Clin Nutr. 2016; 103(6): 1514–22.
  12. Mutgi K, Koo J. Update on the role of systemic vitamin D in atopic dermatitis. Pediatr Dermatol. 2013; 30(3):303-7.
  13. Gamal TS, Madiha AS, Hanan MK, Abdel-Azeem ME, Marian GS. Neonatal and maternal 25-OH vitamin D serum levels in neonates with early-onset sepsis. Children (Basel). 2017; 9; 4(5). pii: E37.
  14. Bouillon R, Carmeliet G. Vitamin D insufficiency: Definition, diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2018; 32(5):669-84.
  15. Aletayeb SM, Dehdashtiyan M, Aminzadeh M, Malekyan A, Jafrasteh S. Comparison between maternal and neonatal serum vitamin D levels in term jaundiced and nonjaundiced cases. J Chin Med Assoc. 2016; 79(11):614-7.
  16. Mutlu M, Çayir A, Çayir Y, €Ozkan B, Aslan Y. Vitamin D and hyperbilirubinaemia in neonates. HK J Paediatr 2013; 18:77-81.
  17. Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in the South of iran (fars province). Iran Red Crescent Med J. 2013; 15(3):260-3.
  18. Ambalavanan N, Carlo WA. Jaundice and Hyperbilirubinemia in the Newborn. In: Kliegman RM, Stanton BF, Schor NF, et al, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Elsevier Saunders; 2011: p. 606- 7.
  19. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752–8.
  20. Fong J, Khan A. Hypocalcemia: updates in diagnosis and management for primary care. Can Fam Physician. 2012;58(2):158–62.
  21. Mehrpisheh S, Memarian A, Mahyar A, Valiahdi NS. Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia. BMC Pediatr. 2018; 26; 18(1):178.
  22. Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G, et al. Incidence, course, and predition of hyperbilirubinemia in near-term and term newborns. Pediatrics. 2004; 113(4):775-80.
  23. Young Infants Clinical Signs Study Group. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet. 2008; 12; 371(9607):135–42.
  24. Bhutani VK. Editorial: building evidence to manage newborn jaundice worldwide. Indian J Pediatr. 2012; 79(2):253–5.
  25. Amoozegar V, Mirshakeri V, PaishvaN Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Male Donors in Shiraz, Southern Iran. Iran J Med Sci. 2005; 30(2):94–6.
  26. Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, et al. Maternal vitamin D status during pregnancy and childhood bone mass at 9 years: a longitudinal study. Lancet. 2006; 7; 367(9504):36-43.
  27. Van der Meer I, Karamali N, Boeke A. High prevalence of vitamin D deficiency in pregnant non‐Western women in The Hague, Netherlands. Am J Clin Nutr 2006;84(2):350-3
  28. Bassir M, Laborie S, Lapillonne A, Claris O, Chappuis MC, Salle BL.Vitamin D deficiency in Iranian mothers and their neonates: a pilot study. Acta Paediatr. 2001; 90(5):577-9.
  29. Scholl TO, Chen X. Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev. 2009; 85(4):231-34.
  30. Kumaratne M, Early G, Cisneros J. Vitamin D deficiency and association with body mass index and lipid levels in Hispanic American adolescents. Glob Pediatr Health. 2017; 4: 2333794X17744141.
  31. DeLuca HF. The control of calcium and phosphorus metabolism by the vitamin D endocrine system. Ann N Y Acad Sci. 1980; 355:1-17.
  32. Shaheen S, Noor SS, Barakzai Q. Serum alkaline phosphatase screening for vitamin D deficiency states. J Coll Physicians Surg Pak. 2012; 22(7):424-7.
International Journal of Pediatrics
Volume 8, Issue 4 - Serial Number 76
April 2020
Pages 11141-11147
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