Resident of Pediatric, Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Associate Professor of Pediatric, Birjand Cardiovascular Research Center, Birjand, Iran.
Professor of Microbiology, Hepatic Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Associate Professor Infectious Disease Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Background: Helicobacter pylori (H. pylori) is believed to be the most common bacterial infection worldwide. Herein, we aimed to investigate the effect of red rose extract on H. pylori eradication in 9 to 15 year-old children.
Method: By the conveniencesampling method 332children were screened for H. pylori infection. Their stool samples were studied by the H. pylori Antigen Enzyme Immunoassay (EIA) Test Kit. Positive cases were divided into two groups and received either red rose extract or placebo for 14 days. The stool exam was repeated once again at treatment termination. The significance level was set at P<0.05.
Results: In total 59 (17.8%) of the 332 cases werepositive for Helicobacter pylori Stool Antigen (HpSA) and 56 completed the study. The mean HpSA titer remained stable in the red rose extract treated group but it increased in the placebo group following intervention; however, the difference was statistically insignificant (P=0.57).Moreover, the intervention resulted in no difference in the eradication rate between the two groups (P=0.57).
Conclusion: Red rose extract did not reduce HpSA titer after intervention and therefore cannot be solely considered as an alternative for H. pylorieradication. Further studies with a different dose and duration or with combined regimens are recommended.