Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Department of Anesthesiology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
Vitamin D is a fat-soluble vitamin that has an important function in bone metabolism, muscle activity, nervous system, and immunity. In this study, we compared the vitamin D level of children with congenital heart disease (CHD) with healthy control.
Materials and Methods
This case-control study was conducted on 56 children with CHD diagnosed with echocardiography and 56 healthy children with no sign of CHD matched for age, sex, and use of vitamin D supplementation. Participants were gathered from those who referred to the cardiac clinic of Vali-e-Asr hospital, Birjand, Iran, in 2017. Two ml of the blood sample was taken from all participants and serum vitamin D was assessed using Roche Diagnostic kit (Germany). The data analysis was achieved using SPSS software version 16 with descriptive statistics and Chi-square test.
The median age of participants was 7 months (ranged1-24). The mean vitamin D serum level of all participants was 32.19 ng/ml (SD=28.79) (normal > 20). The level of vitamin D in the case and control group was 16.82 ng/ml (29.85-9.38), and 34.95 ng/ml (46.60-26.52), respectively; and this difference was significant (P<0.05). In the CHD patients group, 15 patients had vitamin D deficiency and 5 patients had high vitamin D levels. In the healthy patients’ group, these numbers were 2 and 21, respectively.
Based on the results, children with CHD had significantly lower levels of vitamin D; therefore, we suggest more vitamin D supplement be used for patients with CHD than healthy children.