Efficacy of treatment with Fluoxetine in children with breath-holding spells

Authors

1 Resident of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Professor of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Assistant Professor of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Assistant Professor of Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Pharmacist, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction:
Despite the harmless nature of attacks, exposure to it is stressful and sometimes requires treatment. In this study, the efficacy of fluoxetine treatment on breath-holding spells was evaluated.
Methods & Materials:
Thirty patients with Breath-holding spells who referred to neurology clinic of Ghaem hospital in Mashhad were selected and randomly divided into two groups of control and intervention. The number and duration of pre-treatment attacks were recorded in both groups based on a questionnaire. Then in the control group they were treated with iron and in the intervention group they were treated with iron and fluoxetine. Finally, after 3 months of treatment based on the questionnaire, the number and duration of attacks were reviewed.
Results:
Thirty children were studied in this study and were randomly divided into two groups. Mean age of infants, Frequency of male and female, Parental family ratio, Age gap with previous child, Birth Apgar, Frequency Mothers with pregnancy problems, frequency of vaginal delivery and cesarean section, frequency of previous hospitalization, reason for previous hospitalization, absence of trauma and normal development hadn’t significant difference in two groups. There was no significant difference between the two groups before the start of the study. There was no significant difference between the two groups in the time of onset of first attack and onset of attack (p = 0.439).
Conclusion:
The results of this study confirms the effect of iron therapy on decreasing the number and duration of breath holding attacks. At the same time, it shows no effect of fluoxetine on iron to reduce the number and duration of breath holding attacks.

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