Comparison of the therapeutic effect of salbutamol nebulize with different concentrations of saline in children with bronchiolitis

Authors

1 Associate Professor of Pediatric Infectious Disease, Department of Pediatrics, School of Medicine, Children and Adolescents Health Research Center, Research Institute for Drug Resistant Tuberculosis, Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

2 Assistant Professor of Pediatrics, Department of Pediatrics, School of Medicine, Children and Adolescents Health Research Center, Research Institute for Drug Resistant Tuberculosis, Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

3 Resident of Pediatric, Department of Pediatrics, School of Medicine, Ali-Ibn-Abitaleb Hospital, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

Background: Bronchiolitis, most common infection of the lower respiratory tract in infants, characterized by acute inflammation, edema, and increased mucosal production and bronchospasm. Present study was designed, considering the different effects of use of saline at different concentrations and salbutamol in the treatment.
Methods: double-blind randomized clinical trial performed on aged 4 weeks to 24 months admitted to Ali-Ibn-Abitaleb Hospital in Zahedan during 2017-18 for possible diagnosis of acute bronchiolitis. Patients were divided into 3 groups using permissive block method. The first group received 0.15 mg salbutamol nebulize and 5 cc normal saline 0.9%, the second group received saline 3% and the third group received saline 5% at the same dose as the first group. Clinical status, oxygen saturation, respiratory rate and heart rate, intercostal retraction and dyspnea and wheezing before treatment and every 20 minutes after treatment up to 3 times and CBSS were collected.
Results: In all three groups, there was an increasing trend in oxygen saturation and a decreasing in respiratory rate, heart rate and CBSS. In the first and third groups, there was a significant difference in CBSS after treatment, but in the second group it was significant only at 20 and 40 minutes after treatment. Mean days of admission for the second group was lower.
Discussion: It seems that due to its cost-effectiveness, lack of complication and earlier efficacy of 5% hypertonic saline in treatment of bronchiolitis, it seems that afterwards hypertonic saline 5% instead of normal saline 0.9% uses bronchiolitis treatment.

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