Investigating the Effect of Vitamin D Administration on the Recovery Progress of Infants and Children with Congenital Heart Disease Requiring Reconstructive Heart Surgery

Authors

1 MD, Associated Professor Of Pediatric Cardiology, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.

2 MD, Associated Professor Of Cardiac Surgery, Department of Cardiac Surgery, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi Province, Iran.

3 MD, Resident of Pediatrics, Pediatrics Department, Valie-asr Hospital, Birjand University of Medical Sciences, Birjand, Iran.

4 Medical Student, College of Medicine, Birjand University of Medical Sciences, Birjand, Iran.

Abstract

Regular consumption of vitamin D doses can improve heart function in patients with heart failure. The present study aimed to investigate the effect of vitamin D on the recovery process of neonates, infants, and children with Congenital Heart Disease (CHD) following reconstructive cardiac surgery.
Materials and Methods: In this single-blinded clinical trial study, 60children with CHD requiringreconstructive cardiac surgery, who had been referred to the cardiology department of Razi Hospital affiliated to Birjand University of Medical Sciences, Iran in 2019, were selected and randomly divided to the intervention and control groups. Patients in the intervention group received oral vitamin D before operation (300,000 units of vitamin D). 24 and 48 hours after the operation, patients' hemodynamic conditions were assessed and inotropic drugs were administered accordingly.
Results: The mean vitamin D level was 33.21 ± 4.66 ng/ml in the intervention group (with vitamin D) and 23.55 ± 2.68 ng/ml in the control group (P<0.05). The mean RACH category of the intervention and controlgroups was 2.33 ± 0.15 and 2.2 ± 0.14 respectively; there was no significant difference between the two groups in this regard. The relationship between vitamin D level with RACH category score, inotrope score, and vasoactive inotrope score was not significant at 24 and 48 hours after the operation in both groups.
Conclusion
According to the results, the administration of vitamin D had no significant effect on the improvement of patients with the congenital cardiac disease after reconstructive heart surgery.

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