Comparison of Vitamin D Levels in Children with Musculoskeletal Pain with and without Hypermobility of Joints


Department of Pediatric Rheumatology, Bahrami Children’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.


Vitamin D supplementationhas been suggested as a part of an interdisciplinary approach for management of chronic musculoskeletal pain in children and adolescents. We aimed to compare vitamin D serum level between Iranian children with chronic musculoskeletal pain with and without hypermobility.
This cross-sectional study was performed on otherwise healthy children aged 16 years or younger with chronic musculoskeletal pain who attended the rheumatology clinic of Bahrami Children Hospital, Tehran, Iran, from January 2018 to January 2019. Chronic musculoskeletal pain was defined as recurrent episodes of musculoskeletal pain during the past month and most recently, within the past week, were categorized into groups with or without hypermobility. Modified Criteria of Carter and Wilkinson was used to diagnose hypermobility. Serum 25-hydroxy vitamin D (25-(OH)D) level and baseline characteristics were compared and 25-(OH)D <30 ng/mL was considered deficient.
A total of 72 children (41 girls, 31 boys, mean age 7.36 ± 2.42 years) were included. Most participants (73.6%) belonged to the 3-7 year age group.  Sixty-four patients (88.8%) were diagnosed with vitamin D deficiency (25(OH)D <30 ng/mL).  Children without hypermobility had a lower vitamin D level and a higher prevalence of vitamin D deficiency compared to those with hypermobility. However, the difference was not statistically significant.
Our study results suggested a high prevalence of vitamin D deficiency among children and adolescents with chronic musculoskeletal painbut the difference regarding vitamin D deficiency between children with and without hypermobility was not statistically significant.