Investigating the effect of prescribing Vitamin C on improving the clinical symptoms of asthma in 2-12-year-old children hospitalized in the pediatric ward of Ghaem and Dr. Sheikh hospitals, Mashhad, Iran

Authors

1 Associate Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

3 Department of Pediatric Allergy-immunology, Mashhad University of Medical Science, Mashhad, Iran.

4 Nuclear Medicine Specialist, Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

5 Pediatrician, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: Asthma is the most common chronic airway disease in children. We aimed to investigate the effect of vitamin C supplementation on improving the asthma symptoms in children.
Method:
In a double-blind clinical trial: sixty 2-12-year-old children hospitalized with the diagnosis of asthma attack in the Ghaem and Dr. Sheikh hospitals, Mashhad, Iran were randomly assigned into two groups: intervention (receiving vitamin C tablets 500 mg every 12 hours, n=29), and  control (receiving placebo, n=31). In each group, at the beginning and end of the hospitalization, one blood sample (3ml) was taken to evaluate the serum level of vitamin C and for other necessary tests. A pediatric resident recorded clinical symptoms at the beginning and every 6 h until discharged including tachypnea, wheezing, retraction, and hypoxia every six hours until discharge from the hospital. Eventually, the data in the two groups were compared.
Results:
The mean age of the hospitalized patients was 33±24 months. There was a significant difference between the intervention and control groups regarding the serum level of vitamin C at the beginning of hospitalization and at the time of discharge. A significant difference was found in tachypnea of the hospitalized patients of both groups at 24 and 36- hours post hospitalization. Existence of wheezing in the patients of the intervention and control groups had a significant difference at 18, 36, and 66 h post-hospitalization (p<0.05).
Conclusion
According to the results, oral vitamin C prescription in patients with acute asthma symptoms leads to improved respiratory status (tachypnea and wheezing) in 2-12-year-old children. Also, it is effective in reducing the duration of hospitalization of these children.

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