Clinical Characteristics Findings in Children and Adolescents with Covid-19: Systematic Review and Meta-Analysis Study


1 Assistant Professor of Vascular Surgery, Ilam University of Medical Science, Ilam, Iran.

2 Infectious Diseases Department, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

3 Department of Nursing, Faculty of Nursing and Midwifery, Kermanshah University of Medical Science, kermanshah, Iran.

4 Associate Professor of Pediatrics Gastroenterology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

5 Department of Nursing, Faculty of Nursing and Midwifery, Ilam University of Medical Science, Ilam, Iran AND Student Research committee, kermanshah University of Medical Sciences, kermanshah, IR Iran.

6 Università degli Studi "La Sapienza" di Roma, Public Health and Infectious Diseases, Undergraduate, Italy.

7 Assistant Professor of Pediatrics, Department of Pediatrics, Ilam University of Medical sciences, Ilam, Iran.


Introduction: In 2019, an unknown disease called coronavirus spread in China. The disease is widespread in many countries and has endangered the lives of many patients. For this reason, a systematic review and meta-analysis was conducted with the aim of assessment Clinical Characteristics in Children and Adolescents with COVID19.
Materials and Methods: This is a Systematic Review and Meta-Analysis article have been searching all epidemiologic studies of the prevalence of COVID19 worldwide in the children and adolescent group. Search was international databases conducted at Embase, Scopus, Web of Science (ISI), PubMed/Medline, Science Direct and Google Scholar Search Engine. The keywords that were searched included: “Child”, “pediatric”, “adolescents”, “COVID-19” , “coronavirus”, and “Diagnosis” . Data were analyzed using STATA statistic software.
Results:The total number of patients was 2579, of which 1467(56.9%) were male and 1110(43.1) were female.All patients were in the age range of childhood and adolescence.At the beginning of the research, 1356 studies were searched, of which 987 studies entered the next stage and finally the article entered the systematic review and meta-analysis stage with 14 studies. Also the prevalence of fever in children and adolescents was 55.0% (95% CI 0.55 (0.40, 0.70)), the prevalence of cough was 41.0% (95% CI 0.41 (0.27, 0.56)), the prevalence of nasal discharge was 9.0% (95% CI 0.09 (0.05, 0.12)), Diarrhea prevalence 5.0% (95% CI 0.05 (0.02, 0.08)).
Conclusion: It is the results of this study could be a guide for an infectious disease specialist and pediatrician to identify the clinical signs of Covid-19 in children and adolescents.