Faculty Member of Paramedical School, Ilam University of Medical Sciences, Ilam, Iran.
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Department of Midwifery, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran.
Student Research Committee, Kerman University of Medical science, Kerman, Iran.
Neonatal sepsis is a critical condition caused by a generalized bacterial infection in the first month of life. The present study aimed to investigate the relationship between serum vitamin D levels and neonatal sepsis.
Materials and Methods: A search of online databases (Medline, Cochrane Library, Web of Science, EMBASE-Ovid, and Scopus) were carried out for randomized control trials and non-randomized prospective or retrospective clinical studies published in English till April 2020. Two reviewers selected the studies.
Results: In the first study, the level of 25-hydroxyvitamin D [25(OH)D] in the cord-blood sample of infants in the Early-Onset Neonatal Sepsis (EONS) group was significantly lower compared to the control group. 25(OH)D level (19 ng/ml) in the control group were significantly higher compared to the 25(OH) level (8.6 ng/ml) in the sepsis group. In the third study, the serum 25(OH) level showed a significant decrease in the affected neonates (6.4 nmol/L) compared to healthy neonates (42.5 nmol/L). In the fourth study, the sepsis and control group had a significant difference in the level of 25(OH)D (69±7.5ng/ml and 35±19ng/ml). According to the fifth study, the serum 25(OH)D level was insufficient in the case group and sufficient in the control group (p<0.0001). In the sixth study, the odds of very-early-onset neonatal sepsis among the neonates who had the serum 25-hydroxyvitamin D deficiency were lower compared to the odds among neonates who did not have serum 25-hydroxyvitamin D deficiency.
The level of 25-hydroxyvitamin D in the blood sample of infants in the sepsis group was significantly lower compared to the control group; further studies required to confirm the results by considering more confounders.