Corrected Anion Gap and Hypernatremia as a Predictor of Mortality in Pediatric Intensive Care Unit, Minia University Hospital; A Retrospective Study.


1 Professor of Pediatrics, Minia University, Egypt.

2 Resident of Pediatrics, Minia University, Egypt.

3 Associate professor of Pediatrics, Minia University, Egypt.



Background: Hypernatremia is associated with mortality rates as much as 40–60%. Hypernatremia commonly occurs in ICUs, mostly developing after admission, and has been associated with increased mortality and prolonged length of ICU stay. purpose: The aim of our study is to evaluate the value of serum anion gap (AG), corrected anion gap (CAG) and hypernatremia for early prediction of mortality in pediatric intensive care unit (PICU).
Method: This is a retrospective comparative study using data collected from the records of children admitted to the PICU at Minia University Hospital during the period between June 2017 and June 2019.
Results: Patients' ages ranged from 1 month to 18 years. ROC curve analysis for prediction of mortality showed that cut off point of Na was >154 (64.04% Sensitivity&79.75% Specificity) and that of cAG was > 42.1(57.37% Sensitivity&70.25% Specificity).
Conclusion: ventilation, respiratory failure, sever GCS and moderate GCS, PH, CO2, anion gap, high cAG, hypernatremia, K, CL, CRP, PLT, and Creatinine, were significant predictors of mortality among children admitted to PICU.