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Prevalence and Outcomes of Retinopathy of Premature Neonates in Iran: A Systematic Review and Meta-Analysis

Document Type : systematic review

Authors

1 Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran 2- Assistant Professor of Pediatrics, Department of Pediatrics, Ilam University of Medical sciences, Ilam, Iran

2 1 Assistant Professor of Allergy and Clinical Immunology, Department of Pediatrics, School of Medicine Emam Khomeini Hospital, Ilam University of Medical sciences, Ilam, Iran. 2 Assistant Professor of Pediatrics, Department of Pediatrics, Ilam University of Medical sciences, Ilam, Iran.

3 Department of Ophthalmology, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

Abstract

Background: Retinopathy of Prematurity (ROP) is a disease in the retina of premature infants, which is one of the preventable causes of blindness in children.
Methods: the present study is performed with the purpose of determining the prevalence and outcomes of ROP in Iran through a systematic review and meta-analysis.
Study design: All original published articles on the prevalence of ROP in premature infants in Iran were included in the study. On the other hand, intervention articles, meta-analysis, case reports, congress articles, medical dissertations, and articles with low quality were excluded from the study.
Results: 53 articles were included in the meta-analysis stage. Based on the results, the overall prevalence of ROP in Iran was 22.2% (95% CI: 18.5-26.5); the overall prevalence of the disease in ZONE I was 10.5% (95% CI: 3.0-30.6), the overall prevalence of the disease was 45.5% (95% CI: 33.8-57.8) in ZONE II, and 43.8% (95% CI: 25.1-64.4) in ZONE III. Regarding the stage of the disease, rate of 39.9% (95% CI: 29.2–51.7) was reported in STAGE I, rate of 30.3% (95% CI: 21.8–40.5) in STAGE II, and 14.9% (95% CI: 11.0 -19.9) in STAGE III.
Conclusion: Considering the high prevalence of ROP in premature infants in Iran, it is suggested to take necessary preventive measures in this field.

Keywords

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International Journal of Pediatrics
Volume 11, Issue 6
June 2023
Pages 17909-17923
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