Comparison of Growth Impairment in Pediatric Patients with ALL, NHL Treated with Chemotherapy alone and Chemoradiotherapy

Authors

Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction:
Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma(NHL) are the most common cancers in childhood and  adolescence. Most children with ALL and NHL have long term survival (>80%). Endocrinopathy is a common complication in pediatric cancers following the treatment (20-50% prevalence), in addition, cytotoxic chemotherapy and radiotherapy can influence side effect on growth parameters.
 
Material and Methods:
 We evaluated growth percentiles in 50 children with ALL(n=25),NHL(n=25) . Age of our patients was 3-17 years in remission period who received chemotherapy with (n=25) or without (n=25) head and neck radiation. Patients with in less than 5th percentile height referred to assess the growth hormone deficiency (GHD) by insulin stimulating test.
 
Results:
Six (12%) Patients had less than 5th percentile height. From these patients 5 children (83.0% ) had isolated GHD. Cortisol, ACTH, Prolactin , IGF-1and IGF-BP3 were at normal value children underwent   head and neck radiotherapy in addition to chemotherapy. We didn’t find significant difference between 2 treatment group in exact–fisher test (P= 0.189 (. Two patients (4.0%) had over weight in assessing BMI ( Body Mass Index).
 
Conclusion:
We have some patients with short stature and GHD then it is important to pay more attention about growth in pediatric with malignancy.
 
Key words: ALL, Growth Hormone Deficiency, NHL, Radiotherapy.
 
 

Keywords