“Manually Ventilating Test” in Anesthesia Management of Children with Massive Anterior Mediastinal Masses Requiring Tracheal Intubation.A case series


1 Associate professor of anesthesia .Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2 Assistant professor of Anesthesiology. Cardiac Anesthesia Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

3 Anesthesiologist.Imam Reza hospital. Mashhad, Iran

4 Assistant professor of anesthesia. Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran


The risk of life-threatening complications during induction of anesthesia in patients with anterior mediastinal mass is well recognized. Maintenance of spontaneous ventilation during anesthesia is an accepted standard goal in all published reports. However, the decision to paralyze the patient, which is really needed in most surgical procedures, is still a challenging event. In this study, “manually ventilating test” as a predictive test was assessed to make the decision to paralyze children with massive anterior mediastinal masses who needed tracheal intubation. . It seems that manually ventilating test may at least be a simple and reliable test to identify cases that could be paralyzed successfully



 Patients with a large mediastinal mass present a difficult challenge for anesthetists because of compression of adjacent vital structures. Obstruction of the intra-thoracic trachea is a major anesthetic risk for these patients. It is often impossible to maintain a patent airway when the patient lies supine, is deeply anesthetized, or is paralyzed with muscle relaxants. 1, 2 Care of these patients clearly requires individualized and creative approaches.

Difficulty with ventilation and cardiac arrest in the course of anesthesia for diagnostic or therapeutic procedures in patients with mediastinal mass are well described.3-5 Some centers have reported an incidence in pediatric patients of 7–20% during anesthesia and 18% in the postoperative period. The incidence in adults is believed to be much less6, because the narrow compliant airways in children are more susceptible to obstruction. Anesthetic deaths have mainly been reported in children.7

A number of approaches and recommendations are suggested to proceed a safe anesthesia, although they have their own limitations in pediatric patients. As many cases need paralyzing during a procedure, the main question is not answered definitely yet: which patients can receive muscle relaxants safely without producing airway obstruction and catastrophic sequels?

Here we evaluate “manually ventilating test” as a predictive test to make the decision to paralyze children with a mediastinal mass who need tracheal intubation.


 This is a prospective study of 20 symptomatic children with large mediastinal masses who might need tracheal intubation and paralyzing in the course of their elective surgical procedures in our center from 2007 to 2011. These patients were scheduled for biopsy or resection of their mediastinal or neck masses that were diagnosed by CT scan or chest ultrasonography. All patients were anesthetized with sevoflurane and varying mixtures of N2O and O2 or pure O2 depending on their oxygenation status. After a smooth induction and gradually deepening a few manually assisted ventilations were applied as a test to ascertain the efficacy of positive pressure ventilation (PPV). Then, PPV was possible, the patient was paralyzed and intubated by injecting cisatracurium and fentanyl. Afterwards, anesthesia was maintained by propofol or remifentanyl infusion and mixture of N2O and O2. Otherwise, if PPV was not possible manually, the decision to continue anesthesia with spontaneous breathing or to stop anesthesia was made considering the planned procedure and its duration, the patient cardio-respiratory status, and the ability to supplement a regional block. If the decision to continue anesthesia was made, spontaneous ventilation was maintained during the whole time of the procedure and a regional or local anesthesia was supplemented with meticulous attention to prevent pulmonary aspiration. A rigid pediatric bronchoscope was available in the operating room.


 There were 20 symptomatic patients with an average age of 6.30±4.77 year old (1.5 months-14 years old). Pathologic and imaging diagnoses are presented in (Table1).  Nineteen cases could be ventilated manually, all of whom could be paralyzed and intubated successfully. One case scheduled for open thoracotomy could not be ventilated manually, leading to a change in the surgery plan. Spontaneous ventilation was maintained with laryngeal mask airway and ultrasonography-guided needle biopsy was performed. All cases had uneventful anesthesia and recovery.

   Discussion and Conclusion

In addition to continuous monitoring of gas exchange and hemodynamics, different approaches and techniques are recommended for a safe anesthesia in patients with large mediastinal masses. These include maintaining spontaneous ventilation until securing a definite airway or completing the procedure8, preoperatively determining patients’ respiratory flow-volume and peak expiratory flow rate9, predicting tracheal cross-sectional area and anesthetic management by chest CT10, availability of a rigid bronchoscope, and in the presence of severe symptomatic obstruction, tracheal stenting prior to mediastinoscopy11.

Maintaining spontaneous respiration is a well-accepted technique whenever a difficult airway is anticipated. However, the same main concern in unexpected inability of ventilation in paralyzing patients remains unresolved. In a recent study, airway collapse with an anterior mass despite spontaneous breathing in an adult has been reported.12 The authors strongly recommended pre-induction placement of femoral cardiopulmonary bypass (CPB) cannulae and readiness to immediately initiate cardiopulmonary bypass in high-risk patients. These recommendations have been mentioned before.13, 14 However, CPB and bronchoscopy are rather rescue treatments in case of a sudden cardiopulmonary collapse. CPB as a prophylactic procedure is troublesome and if available, reserved only for a few cases with severe cardiopulmonary compromise.

Usefulness of flow-volume loop studies in airway management of these patients has not been demonstrated. 15, 16

Although preoperative pulmonary CT scan may be useful in determining high-risk patients, the same concern still exists. In addition, CT scan is a static study, while airway obstruction is a dynamic event in the patient with anterior mediastinal mass and is dependent on respiratory cycle and patient position. Difficulty in immobilizing a restless child with respiratory distress is another limitation of imaging studies.

Manually ventilating test is a simple, noninvasive maneuver to assess patency of airway during which negative intrapleural pressure is lost. Patency of a narrowed airway in patients with large compressive anterior mediastinal masses is maintained by negative pressure of the surrounding parenchyma. In some severe critical stenosis, it will be lost with any intervention that leads to removal this negative pressure, such as creating apnea by injecting any hypnotic-sedative or muscle-paralyzing drugs. By performing a few “manually assisted "positive ventilations, intrapleural negative pressure will be lost, leading to circumstances as if the patient is paralyzed. Therefore, if positive pressure ventilation is possible easily, it will be possible after injecting muscle relaxants along with intubating the patient. This test was also mentioned in another study17, although it was not analyzed in detail. The most promising result of our study is that of nineteen cases who could be ventilated manually, all of them could be paralyzed, intubated and given PPV successfully. In other words, fortunately this test has no false positive results in our study. Therefore, we can conclude that manually ventilating test may at least be a simple and reliable test to identify cases that could be paralyzed successfully. However, more cases are needed to make a strong recommendation.




  1. Halpern S, Chatten J, and Meadows AT: Anterior mediastinal masses: Anesthetic hazards and other problems. J Pediatr 1983; 102:407.
  2. Hammer GB: Anaesthetic management for the child with a mediastinal mass. Paediatr Anaesth 2004; 14:95.
  3. Keon T. P. Death on induction of anaesthesia for cervical lymphnode biopsy. Anaesthesiology. 1981; 55: 471-472.
  4. Todres I. D., Reppert S. M., Walker P. F., Grillo H. C. Management of critical airway obstruction in a child with mediastinal tumour. Anaesthesiology. 1976; 45: 100-102.
  5. Bittar D. Respiratory obstruction associated with induction of general anaesthesia in a patient with mediastinal Hodgkin’s disease. Anaesthesia and Analgesia. 1975; 54: 399-403.
  6. Bray RJ, Fernandes FJ: Mediastinal tumour causing airway obstruction in anaesthetised children. Anaesthesia 1982; 37:571–5
  7. Victory RA, Casey W, Doherty P, Breatnach F: Cardiac and respiratory complications of mediastinal lymphomas. Anaesth Intensive Care 1993; 21:366–9
  8. Frawley G, Low J, Brown TCK. Anaesthesia for an anterior mediastinal mass with ketamine and midazolam infusion. Anaesth Intens Care 1995; 23:610–612.
  9. Neuman GG, Weingarten AE, Abramowitz RM, et al. The anesthetic management of a patient with an anterior mediastinal mass. Anesthesiology 1984; 60:144–147.
  10. Shamberger RC, Hozman RS, Griscom NT, et al: Prospective evaluation by computed tomography and pulmonary function tests of children with mediastinal masses. Surgery 1995; 118:468.
  11. Ahmed-Nusrath A,   Swanevelder J, Contin Educ Anaesth Crit Care Pain(2007) 7 (1): 6-9.
  12. -Gardner JC, Royster RL: Airway collapse with an anterior mediastinal mass despite spontaneous ventilation in an adult.  Anesth Analg. 2011 Aug; 113(2):239-42.
  13. Tempe DK, Arya R, Dubey S, Khanna S, Tomar AS, Grover V, and Nigam M, Makwane UK: Mediastinal mass resection: Femorofemoral cardiopulmonary bypass before induction of anesthesia in the management of airway obstruction. J Cardiothorac Vasc Anesth 2001; 15:233–6.
  14. Sugiura M, Nakajima J, Morota T, Yamamoto T, Sano A, Fukami T, Murakawa T, and Ota S, Takamoto S: Posterior mediastinal hemangioma successfully resected with cardiopulmonary bypass: Report of a case. Kyobu Geka 2007; 60:857–60
  15. Torchio R, Gulotta C, Perbondi A, et al. Orthopnea and tidal expiratory flow limitation in patients with euthyroid goiter. Chest 2003; 124:133–140.
  16. Hnatiuk OW, Corcoran PC, Sierra P. Spirometry in surgery for anterior mediastinal masses. Chest 2001; 120:1152–1156.
  17. Slinger P, Karsli C: Management of the patient with a large anterior mediastinal mass: recurring myths,Current Opinion in Anaesthesiology 2007, 20:1–3.