Comparison of 25-hydroxyvitamin D and Calcium Levels between Preeclampsia and Normal Pregnant Women and Birth Outcomes

Authors

1 Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

2 Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

3 Department of Midwifery, Estahban branch, Islamic Azad University, Estahban, Iran.

4 Department of Pediatrics, North Khorasan University of Medical Sciences, Bojnurd, Iran.

5 Maternal, Fetal and Neonatal Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Introduction
The main aim of this study was to compare serum level of 25- hydroxyl vitamin D [25(OH) D] between women with preeclampsia and normal individuals and birth outcomes.
Material and Methods
This cross sectional study was conducted on 650 normal primigravida women in their first 24–28 weeks of pregnancy. After 3 months of follow-up, serum levels of 25(OH) D and calcium were measured in 38 preeclampsia women (case) and in 38 normal pregnant (control).  In addition, APGAR scores and newborn parameters were evaluated in infants of two groups.
Results
Preeclampsia was shown in about 5.84% (38 women) of pregnancies. Comparison of 25(OH) D levels between two main groups showed no significant differences (P> 0.05).  Also, the calcium level was lower in preeclampsia women than the normal women (P<0.05). The results revealed a significant correlation between neonatal two groups with regards to gestational age, birth weight, birth length, head circumference and Apgar score in the first minute of birth.
Conclusion
Although the difference of 25(OH) D levels between preeclampsia and healthy wom‌en is not significant, lower levels of serum calcium were associated with preeclampsia. Also, the newborn parameters improved in the neonates of the control group in comparison to those of the preeclampsia group. This difference might have resulted from mothers’ different health statuses.

Keywords