Maternal and Childhood Obesity research Center, Urmia University of Medical Sciences, Urmia, Iran
Nephrology-urology Research Center, Urmia University of Medical Sciences, Urmia, Iran
Urmia University of Medical Sciences, Urmia, Iran
Recently the prevalence of obesity and its comorbidities has increased in children, in the worldwide. Some evidences show that there is a reverse relation between the serum level of 25-hydroxyvitamin D[25(OH)D] and Body mass index (BMI). The purpose of this study was scrutiny response to treatment vitamin D deficiency in obese/overweight children.
Materials and Methods
In this cross sectional study 60 children 5 -15 years old with BMI≥85% were entered. After obtaining of informed consent the calcium, phosphorous, alkaline phosphatase, 25(OH) D and parathyroid hormone (PTH) levels were measured after 8 hours of fasting. According to intensity of vitamin D deficiency, intra muscularly vitamin D3, 300,000 to 600,000 unit was prescribed. All parameters were rechecked after 1 month. Data were analyzed with SPSS- 20 software.
Among total 60 subjects,49 children (81.7%) were overweight and 11 children (18.3%) were obese. Also, all of subjects had vitamin D deficiency. After intervention only 35% got normal level of vitamin D. Mean level of vitamin D in girls were lower than boys. Average level of vitamin D rose significantly after intervention in both overweight and obese groups (P<0.05). The mean PTH level was reduced significantly after intervention in overweight children (P<0.05). Mean levels of calcium and phosphoruswere increased in two groups after intervention, but this is not significant (P>0.05).
With considering high prevalence of vitamin D deficiency in overweight/obese children, low response to treatment and multiple after math complications, we suggest more attention to vitamin D deficiency and renewal and early intervention in these children.