Nutraceuticals in Hyperlipidemic Children: a Systematic Review and Meta-analysis

Authors

1 1Professor, Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Assistant Professor, Department of Biostatitics, Faculty of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Assistant Professor, Pharmacognosy Department, Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.

4 Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

5 Research Assistant, Specialist in Community Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

Background
Dyslipidemia is a major risk for cardiovascular diseases. The aim of this study is to review the effects of nutraceuticals to modify lipid disorders in children.
Materials and Methods
The literature research was conducted in EMBASE, Medline, PubMed, Scopus, ISI Web of Science, and Cochrane library from 2002 until January 2015. The following keywords were used: dyslipidemia, hyperlipidemia, hypercholesterolemia, dietary intervention, nutraceutical, functional food, herbal treatment, non-chemical treatment, children, adolescents, clinical trial.
Results
13 eligible articles were entered in this study. Consumption of nutraceuticals had significant negative effect sizes (weighted mean differences) for triglycerides (-0.97, 95% CI: -1.49, -0.46), total cholesterol (-0.96, 95%CI: -1.67, -0.26), and low density lipoprotein -cholesterol (-0.54, 95%CI: -0.95, -0.13), it had positive effect size for changes of high density lipoprotein-cholesterol (0.43, 95%CI: 0.04, 0.82) .
Conclusion
Findings of this metaanalysis suggest that consumption of nutraceuticals might have beneficial effects on improving dyslipidemia in the pediatric age group.

Keywords