Evaluation of Brain Natriuretic Peptide plasma levels in children with Congenital Heart Diseases

Authors

1 Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan- Iran.

2 Department of Pediatric, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.

3 Department of Pediatric, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Abstract

Objective
This study aimed to assess Brain Natriuretic Peptide in early diagnose of cardiac function in children with Congenital Heart Diseases.
Methodology
This study was performed on children with CHD and healthy. Severity of heart failure modified Ross classification system was used for grouping patients in four classes. For all participants, height, weight and head circumference were measured. From participants 3 cc blood samples was taken and after separation, the plasma placed at temperature of -80 c. After collecting all samples they were in testing using an ELISA BNP kit. For 50 children in control group statistical methods used to generate RV and PA pressure randomly. The data were analyzed using SPSS for Windows, Version, 15.0 (Chicago,SPSS Inc. USA) with 0.05 for the level of significant.
Results
BNP, RV pressure, PA pressure, HB and O2 saturation had different means in cyanotic, Acyanotic and and control significantly. BNP, RV, PA , HB and O2Sat had different means in case and control significantly. , RV, HB and O2 saturation had different means significantly acordance with the sevirity of disease.BNP had correlation with PA and PA had correlation with Qp/Qs ratio ,Rp/Rs ratio , RV and O2Sat significantly .
Conclusion
At the end from the results of the study concluded that BNP levels in children with chd increased.
in patients with pulmonary hypertension , with increasing the level of pulmonary hypertension the BNP will increase. BNP increasing had high association with the severity of heart failure.

Keywords