Journal of Pediatric Perspectives

Evaluation of Bone Mineral Density in Children with Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL)

A Ghasemi; A Banihashem; N Ghaemi; S Elmi; H Esmaeili; R Erfani Sayyar; Sam Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 68-68

https://doi.org/10.22038/ijp.2014.2536

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) are the most common childhood and adolescence malignancy respectively.Due to the increasing survival ... Read More Introduction: Acute lymphoblastic leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) are the most common childhood and adolescence malignancy respectively.Due to the increasing survival of these children, today late side effects of treatments are important. Therapies such as corticosteroids, cytotoxic and radiotherapy effect on bone density and put the child at risk of osteoporosis and pathological fractures. Material and Methods: This 3-year cross sectional study was performed in Dr. Sheikh Children's Hospital in Mashhad on 50 children with ALL (n=25) and NHL (n=25). Half of them were received (n= 25) chemotherapy alone and half of them chemotherapy plus radiotherapy (n=25). All children were in the remission phase. We assessed them by DEXA bone mineral densitometry (BMD) on the lumbar spine and femoral neck (hip). We also measured some bone biomarkers include calcium (ca), phosphorus (p), parathoromone (PTH), alkaline phosphatase (ALP) in plasma. Results by age, height, sex and Body Mass Index (BMI) were adjusted with a special software. Results: Mean age was 8.28 ± 3.93 years. There was no significant difference on bone biomarkers (Ca, P, ALP.PTH) between ALL, NHL and also between the two treatment groups. Children with ALL had lower density at the hip and lumbar spine. (Respectively p value < 0.001 and p value =0.018 ) . A total of 50 patients, the hip BMD showed normal results in 3 patients (6%) , in 14 patients (28%) osteopenia were seen and 33 patients (66%) had osteoporosis. In whom received radiotherapy plus chemotherapy, one patient had normal BMD and 24 patients (48% of total patients) at the hip and 22 patients (44%) at lumbar spine had decreased BMD. In contrast, in whom had only chemotherapy, 24 patients (48%) had osteoporosis at hip and 23 (46%) at the lumbar spine. There was no significant difference in BMD between the sexes. Conclusion: Given that 94% of children had abnormal bone density, Seem to pay more attention to the metabolic status and BMD in children with cancer can develop appropriate strategies to improve health and quality of their life. Keywords: Acute Lymphoblastic Leukemia (ALL), Bone Mineral Density, chemotherapy, Non-Hodgkin's Lymphoma (NHL), Radiotherapy.

Infective Endocarditis in Children Hospitalized During 10 Years in Imam Reza Hospital- Mashhad

H Mottaghi Moghadam; M Horri; S Elmi; N Motevalli Haghi; R Erfani Sayyar; Sh Rahmani; Sam Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 69-69

https://doi.org/10.22038/ijp.2014.2537

Abstract

Introduction: Infective endocarditis is a rare, fatal ,with high morbidity in children, Since infective endocarditis in children was not assessed in our conditions so our study was ... Read More

Comparison of Growth Impairment in Pediatric Patients with ALL, NHL Treated with Chemotherapy alone and Chemoradiotherapy

A Ghasemi; A Banihashemi; N Ghaemi; S Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 73-73

https://doi.org/10.22038/ijp.2014.2541

Abstract

Introduction: Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma(NHL) are the most common cancers in childhood and adolescence. Most children with ALL and NHL ... Read More

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Author = Elmi, S

Evaluation of Bone Mineral Density in Children with Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL)

Abstract

Infective Endocarditis in Children Hospitalized During 10 Years in Imam Reza Hospital- Mashhad

Abstract

Comparison of Growth Impairment in Pediatric Patients with ALL, NHL Treated with Chemotherapy alone and Chemoradiotherapy

Abstract