ORIGINAL_ARTICLE
Umbilical Cord Clamping Timing in Preterm Infants Delivered by Cesarean Section
Background: The timing of umbilical cord clamping may affect the need to bloodtransfusion and other morbidities of preterm infants. This study aimed to compare three different cord clamping timing (immediate cord clamping, delayed cord clamping and umbilical cord milking) in preterm infants delivered by cesarean section (CS).Materials and MethodsA controlled randomized clinical trial was done in preterm infants with gestation age less than 32 weeks delivered by CS in AlZahra hospital, Tabriz, Iran from June 2018 up to the end of January 2019. They were randomly allocated in three groups consisted of 30 neonates in each group. Umbilical cord was clamped within 10 seconds after infant delivery in immediate cord clamping (ICC) group, 60 seconds after delivery in delayed cord clamping (DCC) group. Cord was milked toward the infant three times over two seconds duration in umbilical cord milking (UCM) group. All patients were followed until discharge for needing the blood transfusion, bronchopulmonary dysplasia and mortality.Results: A total of 20 neonates of 90 studied neonates needed blood transfusion during hospital stay, of which, 4 neonates (13.3%) were in UCM group, 7 neonates (23.3%) in DCC group and 9 patients (30%) in ICC group (P= 0.27). The mean hemoglobin was significantly higher in UCM group at admission and 30 days after birth (P<0.05).ConclusionUCM may be as effective as DCC to increase hemoglobin in preterm infants delivered by CS. Although the hemoglobin of infants with DCC and UCM was significantly higher than infants with ICC, the rate of blood transfusion was not significantly decreased during hospital stay.
https://ijp.mums.ac.ir/article_13952_fba04adf18cc1840cabef8bb5710fd57.pdf
2020-04-01
11095
11101
10.22038/ijp.2019.43193.3606
Blood transfusion
Cesarean section
preterm infants
umbilical cord clamping
Manizheh
Mostafa Gharehbaghi
gharehbaghimm@yahoo.com
1
Professor of Pediatrics and Neonatology, Womens' Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
LEAD_AUTHOR
Sanaz
Yasrebinia
sanaz.1359@yahoo.com
2
Neonatologist, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Parvin
Mostafa Gharabaghi
pm_gharabaghi@yahoo.com
3
Professor of Obstetrics and Gynecology, Women’s Reproductive Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
1- March MI, Hacker MR, Parson AW, Modest AM, de Vecino M. The effects of umbilical cord milking inextermely preterm infants: A randomized controlled trial. J Perinatol 2013; 33: 763-67.
1
2- Strauss RG, Moch DM, Johnson KJ, Cress GA, Burmeistewr LF, Zimneman MB, et al. A randomized clinical trial comparing immediate versus delayed claming of umbilical cord in preterm infants: short term clinical and laboratory endpoints.Transfusion 2008; 48: 658-65.
2
3- Committee on Obstetric practice committee opinion No. 684: delayed umbilical cord clamping after birth. ObstetGynecol 2017; 129:e5-10.
3
4- Moradi WT, Morris J, Kiby A, Robledo K, Askie L, Brown R, et al. delayed cord clamping in preterm infants. The New Engl J Med. 2012; 377:2445-55.
4
5- Rabe H, Reynolds G, Diaz-Rossello JL. A systematic review and meta-analysis of a brief delay in clamping of umbilical cord of preterm infants. Neonatology 2008; 93:138-44.
5
6- Manley BJ, Owen LS, Hooper SB, Jacobs SE, Cheong JLY, Doyle LW, et al. Towards evidence based resuscitation of newborn infants. Lancet 2017; 389: 1639-48.
6
7- Robe H, Reynolds G, Draz- Rossello J. A systematic review and meta-analysis of a brief delay in clamping the umbilical cord of preterm infants. Neonatology 2008; 93: 138-44.
7
8- Al-Wassian H, Shah PS. Efficacy and safety of cord milking at birth: a systematic review and meta- analysis. JAMA Pediatr 2015; 169 (1):18-25.
8
9- Aladangady N, Mc Hugh S, Aitchinsov TC, Wardrop CA, Holland BM. Infants blood volume in a controlled trial of placental transfusion at preterm delivery. Pediatr 2008; 117 (1):93-98.
9
10- Struss RG, Mock DM, Johnson K, Mock NI, Cress G, Knosp L, et al. circulating RBC volume measured with biotinylated RBCs is superior to the hematocrit to document the hematologic effect of delayed versus immediate umbilical cord clamping in preterm neonates. Transfusion 2003: 43 (8): 1168-1172.
10
11- McDonnel M, Henderson-Smat DJ.Delayed umbilical cord clamping in preterm infants: A feasibility study. J Pediatr Child Health 1997; 33 (4): 308-10.
11
12- Fogarty M, Osborn DA, Askie L, Seider AL, Hunter K, Lui K, et al. delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis. Am J Obstet Gynecol 2018. Doi 10.1016/j.ajog. 2017.10.231.
12
13- Rabe H, Diaz- Rosello JL, Duley L, Dowsewell T. Effect of timing umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes. Cochrane Database Syst Rev 2012; 15 (8): CD003248. doi: 10.1002/14651858.CD003248.pub3.
13
14-katheria AC, Truong G, Cousins L, Oshiro B, Finer NN.Umbilical cord versus delayed cord clamping in preterm infants. Pediatrics 2015; 136 (1): 61-9.
14
15- kumar B, Upadhyay A, Gothwal S, Jaiswal V, Joshi P, Dubey K. Umbilical cord milking and hematological parameters in moderate to late preterm neonates: a randomized controlled trial. IndianPediatr 2015; 52: 753-57.
15
16- Alsafadi TRM, Hashmi SM, Youssef HA, SulimanAK, Mansour Abbas H, Albaloushi MH . J Clin Neonatol. 2014; 3 (2): 93–98.
16
17-Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Resp Crit Care. 2001. 163: 1723-29.
17
18- Weiner G M, Zaichkin J, American Academy of Pediatrics and American Heart Association.
18
Textbook of Neonatal Resuscitation (NRP), 7th Ed. 2016.
19
19-Tarnow-Mordi W, Morris J, Kirby A, et al. Delayed versus immediate cord clamping in preterm infants. N Engl J Med 2017; 377:2445-55.
20
20- Gokalp AS, Gunlemez A, Oguz D. Umbilical Cord Clamping Time in Premature Infants. J Neonatal Biol 2017, 6:1.DOI:10.4172/2167-0897.1000248
21
21- Colm P.F. O’Donnell, M.B., B.Ch. The Timing of Cord Clamping for Preterm Infants N Engl J Med. 2017; 377;25 :2488-2489.
22
22- Prockop DJ, Oh JY. Mesenchymal stem/stromal cells: roles as guardians of inflammation. Mol Ther 2012; 20: 14-20.
23
ORIGINAL_ARTICLE
Evaluation of Clinical Course in Children and Adolescents with Atrial Septal Defects
BackgroundAtrial septal defects (ASDs) are the most common third congenital heart defects. This study aimed to evaluate the clinical course of ASDs and the relationship between its complications, location closure and size. Materials and Methods: This cross-sectional study was conducted in the cardiac center of the pediatric ward in Zahedan, Iran. The study was carried out on 529 children with ASD between 2003 and 2018. The ASD children underwent echocardiography and complete examination such as physical exams, ECG and chest X-ray at every visit during follow-up. A diagnosis of ASDs was confirmed by a transthoracic echocardiography. A unique cardiologist applied transthoracic echocardiography to get information about size, location, and the number of the defects as well as hemodynamic information such as pulmonary artery pressure and any associated lesions. The data were analyzed using SPSS software version 20.0. Results: From 529 ASD children, 278 (52.5%) were girls. Most were medium (46.1%). 44.2% were closed by surgery; about 90.9% were secundum. 133 closed spontaneously and 14.6% by device. ASDs size had significant association with closure, location, and complication (P<0.001). The sinus venosus occurred in 29 patients, of which 62.07% and 37.93% were medium and large, respectively. PH was observed in nine children, 88.89% were large. ASD closure had significant association with location, and complication (P<0.001). From secundums, surgery and occluder devices closed 40.75% and 15.80, respectively. From those closed by surgery, 8.12% had residuals, 10.26% were partial anomalous pulmonary venous connection (PAPVC) as comorbidities, and 3.42% had pulmonary hypertension. Conclusion: From the study concluded ASDs size had significant association with closure, location, and complication and ASDs closure had significant association with location and complication.
https://ijp.mums.ac.ir/article_13951_59e508b36419771a095c0f8c1447227d.pdf
2020-04-01
11103
11114
10.22038/ijp.2019.43265.3609
Atrial Septal Defect
Children
Clinical course
Noormohammad
Noori
dr_noori_cardio@yahoo.com
1
Pediatric Cardiologist, Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
AUTHOR
Alireza
Teimouri
alirezateimouri260@gmail.com
2
M.Phil, PhD in Demography, Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, School of Medicine, Zahedan University of Medical Sciences, Zahedan 9816743111, Iran.
LEAD_AUTHOR
Tal Geva, Jose D Martins, Rachel M Wald, Atrial septal defects. Lancet 2014; 383: 1921–32
1
van der Linde D, Konings EE, Slager MA, et al. Birth prevalence of congenital heart disease worldwide: a systematic review and meta-analysis. J Am Coll Cardiol 2011;58:2241-7.
2
Amel-Shahbaz S, Behjati-Ardakani M, Namayandeh SM, Vafaeenasab M, Andishmand A, Moghimi S, et al. The epidemiological aspects of congenital heart disease in central and southern district of Iran. Adv Biomed Res. 2014;3:233. doi: 10.4103/2277-9175.145732.
3
Chelu RG, Horowitz M, Sucha D, Kardys I, Ingremeau D, Vasanawala S, Nieman K, Paul JF, Hsiao A. Evaluation of atrial septal defects with 4D flow MRI-multilevel and inter-reader reproducibility for quantification of shunt severity. 2018 Aug 31;
4
Gatzoulis MA, Alonso-Gonzalez R, Beghetti M. Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease. European Resp Rev 2009;18:154–161.
5
Behjati-Ardakani M, Golshan M, Akhavan-Karbasi S, Hosseini SM, Behjati-Ardakani MA, Sarebanhassanabadi M. The clinical course of patients with atrial septal defects. Iranian journal of pediatrics. 2016 Aug;26(4).
6
Tanghöj G, Odermarsky M, Naumburg E, Liuba P. Early complications after percutaneous closure of atrial septal defect in infants with procedural weight less than 15 kg. Pediatric cardiology. 2017 Feb 1;38(2):255-63
7
8. Nashat H, Montanaro C, Li W, Kempny A, Wort SJ, Dimopoulos K, Gatzoulis MA, Babu-Narayan SV. Atrial septal defects and pulmonary arterial hypertension. Journal of thoracic disease. 2018 Sep;10(Suppl 24):S2953.
8
Refaei M, Islam S, Mackie AS, Atallah J. Correlation of electrocardiogram parameters and hemodynamic outcomes in patients with isolated secundum atrial septal defects. Annals of pediatric cardiology. 2017 May;10(2):152.
9
McMahon CJ, Feltes TF, Fraley JK, Bricker JT, Grifka RG, Tortoriello TA, Blake R, Bezold LI. Natural history of growth of secundum atrial septal defects and implications for transcatheter closure. Heart. 2002 Mar 1;87(3):256-9.
10
11. Fiszer R, Szkutnik M, Chodór B, Białkowski J. Spontaneous closure of a large atrial septal defect in an infant. Postepy Kardiol Interwencyjnej. 2014;10(4):264-6.12. Saito T, Ohta K, Nakayama Y, Hashida Y, Maeda A, Maruhashi K, Yachie A. Natural history of medium-sized atrial septal defect in pediatric cases. Journal of cardiology. 2012 Sep 1;60(3):248-51.
11
Hanslik A, Pospisil U, Salzer-Muhar U, Greber-Platzer S, Male C. Predictors of spontaneous closure of isolated secundum atrial septal defect in children: a longitudinal study. Pediatrics. 2006;118(4):1560–5. doi: 10.1542/peds.2005-3037.
12
Rossi RI, Cardoso Cde O, Machado PR, et al. Transcatheter closure of atrial septal defect with Amplatzer device in children aged less than 10 years old: immediate and late follow-up. Catheter Cardiovasc Interv 2008;71:231–6
13
Rastegari M, Redington A, Sullivan ID. Influence of the introduction of Amplatzer device on the interventional closure of defects within the oval fossa in children. Cardiol Young 2001;11:521–5.
14
Vogel M, Berger F, Dahnert I, Ewert P, Lange PE. Treatment of atrial septal defects in symptomatic children aged less than 2 years of age using the Amplatzer septal occluder. Cardiol Young 2001;10: 534 –7.
15
Butera G, Biondi-Zoccai G, Sangiorgi G, Abella R, Giamberti A, Bussadori C, et al. Percutaneous versus surgical closure of secundum atrial septal defects: A systematic review and metaanalysis of currently available clinical evidence. EuroIntervention 2011; 7: 377 – 385.
16
18. Farooqi M, Stickley J, Dhillon R, Barron DJ, Stumper O, Jones TJ, Clift PF, Brawn WJ, Drury NE. Trends in surgical and catheter interventions for isolated congenital shunt lesions in the UK and Ireland. Heart. 2019 Jul 1;105(14):1103-8.
17
Moore J, Hegde S, El-Said H, Beekman R 3rd, Benson L, Bergersen L, Holzer R, Jenkins K, Ringel R, Rome J, Vincent R, Martin G; ACC IMPACT Steering Committee. Transcatheter device closure of atrial septal defects: a safety review. JACC Cardiovasc Interv 2013;6:433–442.
18
20. Werner RS, Prêtre R, Maisano F, Wilhelm MJ. Fracture of a Transcatheter Atrial Septal Defect Occluder Device Causing Mitral Valve Perforation. The Annals of thoracic surgery. 2019 Jul 1;108(1):e29-30.
19
Kodaira M, Kawamura A, Okamoto K, Kanazawa H, Minakata Y, Murata M, Shimizu H, Fukuda K. Comparison of clinical outcomes after transcatheter vs. minimally invasive cardiac surgery closure for atrial septal defect. Circulation Journal. 2017:CJ-16
20
ORIGINAL_ARTICLE
Evaluation of Some Caries-Related Factors in the Saliva of 3-5 Year Old Children in Sari, Northern Iran
Background: Dental caries is one of the most common oral diseases in pre-school children. Several factors can affect caries process. Aim of this study was comparison of some of the chemical properties of saliva such as total antioxidant capacity, total protein, pH, nitric oxide level in caries free (CF), and caries active (CA) children.Materials and MethodsThis cross-sectional based study was designed with random selection of 80 healthy population including 40 CF and 40 CA children (3-5 years old) from several public kindergartens in Sari, Iranin 2019. Caries status was assessed using DMFT (Decayed/Missing/Filled Teeth) index according to WHO criteria. Un-stimulated saliva samples were collected from children in the morning. Then, several caries-related factors including total antioxidant capacity, nitric oxide, total protein concentration and pH were assessed in saliva samples. Data were analyzed using SPSS software version 16.0.Results: Significant higher total antioxidant capacity and total protein concentration were observed in the saliva of CA than in the CF children. On the other hand, nitric oxide level was markedly lower in CA samples. In addition, a decrease in pH of saliva was observed in CA children.ConclusionBased on the results, increase in the total antioxidant capacity and total protein as well as decrease in nitric oxide levels in the saliva of CA children can be considered as valuable evidence of dental caries occurrence among children.
https://ijp.mums.ac.ir/article_13888_11192b490c370e062c321c34c51eb10e.pdf
2020-04-01
11115
11123
10.22038/ijp.2019.42952.3598
Dental Caries
Nitric oxide
Total antioxidant capacity
pH
Total protein
Fatemeh
Shaki
fshaki.tox@gmail.com
1
Pharmaceutical Science Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran AND Assistant Professor, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Milad
Arab-Nozari
miladnozari.tox@gmail.com
2
PhD Candidate in Toxicology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Faezeh
Maleki
sepide.maleki_d@yahoo.com
3
Student of Dentistry, Department of Pediatric Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Jamshid
Yazdani Charati
jamshid.charati@gmail.com
4
Professor, Department of Biostatistics, School of Health Sciences, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Azam
Nahvi
azamnahvi.pedodontist@gmail.com
5
Assistant Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
LEAD_AUTHOR
Hoceini A, Khelil NK, Ben-Yelles I, Mesli A, Ziouani S, Ghellai L, et al. Caries-related factors and bacterial composition of supragingival plaques in caries free and caries active Algerian adults. Asian Pacific journal of tropical biomedicine. 2016;6(8): 720-6.
1
2. Palmer C, Kent Jr R, Loo C, Hughes C, Stutius E, Pradhan N, et al. Diet and caries-associated bacteria in severe early childhood caries. Journal of dental research. 2010;89(11):1224-9.
2
3. Lee Y-H, Wong DT. Saliva: an emerging biofluid for early detection of diseases. American journal of dentistry. 2009;22(4):241.
3
4. Muchandi S, Walimbe H, Bijle M, Nankar M, Chaturvedi S, Karekar P. Comparative evaluation and correlation of salivary total antioxidant capacity and salivary pH in caries-free and severe early childhood caries children. J Contemp Dent Pract. 2015;16(3):234-7.
4
5. Vahidirad M, Arab-Nozari M, Mohammadi H, Shaki F. Protective Effect of Edaravone against Nephrotoxicity and Neurotoxicity of Acute Exposure to Diazinon. Journal of Mazandaran University of Medical Sciences. 2018;28(165):175-82.
5
6. Subramanyam D, Gurunathan D, Gaayathri R, Priya VV. Comparative evaluation of salivary malondialdehyde levels as a marker of lipid peroxidation in early childhood caries. European journal of dentistry. 2018;12(1):67.
6
7. Dodwad R, Betigeri AV, Preeti B. Estimation of total antioxidant capacity levels in saliva of caries-free and caries-active children. Contemporary clinical dentistry. 2011;2(1):17.
7
8. Doel J, Hector M, Amirtham C, Al‐Anzan L, Benjamin N, Allaker R. Protective effect of salivary nitrate and microbial nitrate reductase activity against caries. European journal of oral sciences. 2004;112(5):424-8.
8
9. Tulunoglu Ö, Demirtas S, Tulunoglu I. Total antioxidant levels of saliva in children related to caries, age, and gender. International Journal of Paediatric Dentistry. 2006;16(3):186-91.
9
10. Ahmadi-Motamayel F, Goodarzi M, Hendi S, Abdolsamadi H, Rafieian N. Evaluation of salivary flow rate, pH, buffering capacity, calcium and total protein levels in caries free and caries active adolescence. Journal of Dentistry and Oral Hygiene. 2013;5(4):35-9.
10
11. de Sousa MC, Vieira RB, dos Santos DS, Carvalho CAT, Camargo SEA, Mancini MNG, et al. Antioxidants and biomarkers of oxidative damage in the saliva of patients with Down's syndrome. Archives of oral biology. 2015;60(4):600-5.
11
12. Astaneie F, Afshari M, Mojtahedi A, Mostafalou S, Zamani MJ, Larijani B, et al. Total antioxidant capacity and levels of epidermal growth factor and nitric oxide in blood and saliva of insulin-dependent diabetic patients. Archives of medical research. 2005;36(4):376-81.
12
13. Habibi E, Arab-Nozari M, Elahi P, Ghasemi M, Shaki F. Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress related damage in an experimental model of ethanol-induced hepatotoxicity. Applied Physiology, Nutrition, and Metabolism. 2018(ja).
13
14. Mashayekhi F, Aghahoseini F, Rezaie A, Zamani M, Khorasani R, Abdollahi M. Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis. J Contemp Dent Pract. 2005;6(4):46-53.
14
15. Syed M, Sachdev V, Chopra R. Intercomparison of salivary nitric oxide as a biomarker of dental caries risk between caries-active and caries-free children. European Archives of Paediatric Dentistry. 2016;17(4):239-43.
15
16. Warren JJ, Blanchette D, Dawson DV, Marshall TA, Phipps KR, Starr D, et al. Factors associated with dental caries in a group of American Indian children at age 36 months. Community dentistry and oral epidemiology. 2016;44(2):154-61.
16
17. Eagappan AS, Rao VAP, Sujatha S, Senthil D, Sathiyajeeva J, Rajaraman G. Evaluation of salivary nitric oxide level in children with early childhood caries. Dental research journal. 2016;13(4):338.
17
18. Kumar SV, Kumar RH, Bagewadi N, Krishnan NA. A study to correlate dental caries experience with total antioxidant levels of saliva among adolescents in Mangalore. Journal of Indian Association of Public Health Dentistry. 2015;13(2):122.
18
19. Shokrzadeh M, Shaki F, Mohammadi E, Rezagholizadeh N, Ebrahimi F. Edaravone decreases paraquat toxicity in a549 cells and lung isolated mitochondria. Iranian journal of pharmaceutical research: IJPR. 2014;13(2):675.
19
20. Alajbeg IZ, Lapić I, Rogić D, Vuletić L, Andabak Rogulj A, Illeš D, et al. Within-subject reliability and between-subject variability of oxidative stress markers in saliva of healthy subjects: a longitudinal pilot study. Disease markers. 2017;2017.
20
21. Battino M, Ferreiro M, Gallardo I, Newman H, Bullon P. The antioxidant capacity of saliva. Journal of Clinical Periodontology: Review article. 2002;29(3):189-94.
21
22. Hegde A, Rai K, Padmanabhan V. Total antioxidant capacity of saliva and its relation with early childhood caries and rampant caries. Journal of Clinical Pediatric Dentistry. 2009;33(3):231-4.
22
23. Preethi B, Reshma D, Anand P. Evaluation of flow rate, pH, buffering capacity, calcium, total proteins and total antioxidant capacity levels of saliva in caries free and caries active children: an in vivo Indian Journal of Clinical Biochemistry. 2010;25(4):425-8.
23
24. Lumikari M, Soukka T, Nurmio S, Tenovuo J. Inhibition of the growth of Streptococcus mutans, Streptococcus sobrinus and Lactobacillus casei by oral peroxidase systems in human saliva. Archives of oral biology. 1991;36(2):155-60.
24
25. Kanehira T, Shibata K, Kashiwazaki H, Inoue N, Morita M. Comparison of antioxidant enzymes in saliva of elderly smokers and non‐smokers. Gerodontology. 2006;23(1):38-42.
25
26. Kumar D, Pandey RK, Agrawal D, Agrawal D. An estimation and evaluation of total antioxidant capacity of saliva in children with severe early childhood caries. International journal of paediatric dentistry. 2011;21(6):459-64.
26
27. Van Nieuw Amerongen A, Bolscher JG, Veerman EC. Salivary proteins: protective and diagnostic value in cariology? Caries research. 2004;38(3):247-53.
27
28. da Silva PV, Troiano JA, Nakamune ACM, Pessan JP, Antoniali C. Increased activity of the antioxidants systems modulate the oxidative stress in saliva of toddlers with early childhood caries. Archives of oral biology. 2016;70:62-6.
28
29. Michelle Hurlbutt R, Novy B, Young D. Dental Caries: A pH-mediated disease. mouth.10:11.
29
30. Shetty C, Hegde MN, Devadiga D. Correlation Between Dental Caries With Salivary Flow, Ph, And Buffering Capacity In Adult South Indian Population: An In-Vivo Study. International Journal of Research in Ayurveda & Pharmacy. 2013;4(2).
30
ORIGINAL_ARTICLE
Determinants of Exclusive Breastfeeding Practices in Kandahar, Afghanistan: A Cross-Sectional Analytical Study
BackgroundIt is recommended for mothers to start breastfeeding their infants within the first hour after birth and exclusively breastfeed them for the first 6 months of their life. Exclusive breastfeeding (EBF) has both short- and long-term benefits for both mother and infant. Main objective of this study was to establish the determinants of EBF practices among mothers in Kandahar, Afghanistan.Materials and MethodsThis was a cross-sectional analytical study conducted in Kandahar, Afghanistan. Researcher-made questionnaire was used to collect the data from 1,028 mothers with children (June–November, 2018). Data was analysed using SPSS software version 22.0 ResultsAmong 1,028 mothers, 95.9% were uneducated, 53.9% had low socio-economic status, and 94.2% had ante-natal care (ANC) visits. EBF rate was 51.2% (526/1028). During first 6 months of life, 11.1% of the infants were given foods other than milk while 51.4% used pacifier. Weaning was started in nearly half (49.2%) of the infants before 6 months of age. Main barriers to EBF were living in city, male gender, giving sedative syrup (Promethazine) to infant, breastfeeding the infant ≥8 times in 24 hours, and giving expressed milk.ConclusionEBF rate in Kandahar is better than many parts of the world, but there are still many barriers that need to be removed. Main barriers of EBF rate in Kandahar needs to be decreased by increasing the health education and overall education status of the mothers.
https://ijp.mums.ac.ir/article_13960_b9888b127a35ed41ad1b0986c3f62786.pdf
2020-04-01
11125
11140
10.22038/ijp.2019.42987.3601
Breastfeeding
Barriers
Human Milk
Lactation
Risk factors
weaning
Bilal Ahmad
Rahimi
drbilal77@yahoo.com
1
Associate Professor and Head, Department of Pediatrics, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
LEAD_AUTHOR
Enayatullah
Mohammadi
ena1200@yahoo.com
2
Head of Comprehensive Health Clinic, Mirza Mohammad Khan Qalacha CHC, Kandahar Directorate of Public Health, Kandahar, Afghanistan.
AUTHOR
Mohammad Haroon
Stanikzai
haroonstanikzai1@gmail.com
3
Assistant Professor and Head, Department of Public Health, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
AUTHOR
Abdul Wahed
Wasiq
wahed330@gmail.com
4
Professor and Head, Department of Internal Medicine, Faculty of Medicine, Kandahar University, Kandahar, Afghanistan.
AUTHOR
Horta BL, Victora CG. Long-term effects of breastfeeding: A systematic review. World Health Organization. 2013 [cited 2019 Aug 18]. Available from: https://www.who.int/maternal_child_adolescent/documents/breastfeeding_long_term_effects/en/
1
Victora CG, Bahl R, Barros AJD, França GVA, Horton S, Krasevec J, et al. Breastfeeding in the 21st century: Epidemiology, mechanisms, and lifelong effect. Lancet. 2016;387(10017):475–90.
2
Rajeshwari K, Bang A, Chaturvedi P, Kumar V, Yadav B, Bharadva K, et al. Infant and young child feeding guidelines: 2010. Indian Pediatr. 2010;47(12):995–1004.
3
Pakpour A, Alijanzadeh M, Pouresmaeil M, Taherkhani F, Mohammadgholiha R, Jozi N. Predictive Factors Associated with Breastfeeding Initiation and Duration Behaviors of 6-months Postpartum Mothers Referred to Health Centers in the City of Qazvin Based on Theory of Planned Behavior. ranian J Heal Educ Heal Promot. 2016;4(1):20–30.
4
Debes AK, Kohli A, Walker N, Edmond K, Mullany LC. Time to initiation of breastfeeding and neonatal mortality and morbidity: A systematic review. BMC Public Health. 2013;13(SUPPL.3):S19.
5
Jamei F, Ostovar A, Javadzade H. Predictors of exclusive breastfeeding among nulliparous Iranian mothers: Application of the theory of planned behavior. Int J Pediatr. 2017;5(3):4457–67.
6
Jarlenski MP, Bennett WL, Bleich SN, Barry CL, Stuart EA. Effects of breastfeeding on postpartum weight loss among U.S. women. Prev Med (Baltim). 2014;69:146–50.
7
Babita, Kumar N, Singh M, Malik JS, Kalhan M. Breastfeeding Reduces Breast Cancer Risk: A Case-Control Study in North India. Int J Prev Med. 2014;5(6):791–795.
8
Assarian F, Moravveji A, Ghaffarian H, Eslamian R, Atoof F. The association of postpartum maternal mental health with breastfeeding status of mothers: A case-control study. Iran Red Crescent Med J. 2014;16(3):e14839.
9
Esfandiyari R, Moghadam MHB, Khakshour A, Faroughi F, Saeidi M. Study of maternal knowledge and attitude toward exclusive breast milk feeding (BMF) in the first 6 months of infant in yazd-iran. Int J Pediatr. 2014;2(3):175–81.
10
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Haghighi M, Taheri E. Factors associated with breastfeeding in th7e first hour after birth, in baby friendly hospitals, Shiraz-Iran. Int J Pediatr. 2015;3(5):889–96.
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Sharma M, Kanani S. Grandmothers’ influence on child care. Indian J Pediatr. 2006;73(4):295–8.
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Seid AM, Yesuf ME, Koye DN. Prevalence of Exclusive Breastfeeding Practices and associated factors among mothers in Bahir Dar city, Northwest Ethiopia: a community based cross-sectional study. Int Breastfeed J. 2013;8(1):14.
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Matovu A, Kirunda B, Rugamba-Kabagambe G, Tumwesigye NM, Nuwaha F. Factors influencing adherence to exclusive breast feeding among HIV positive mothers in Kabarole district, Uganda. East Afr Med J. 2008;85(4):162–70.
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Onah S, Osuorah DIC, Ebenebe J, Ezechukwu C, Ekwochi U, Ndukwu I. Infant feeding practices and maternal socio-demographic factors that influence practice of exclusive breastfeeding among mothers in Nnewi South-East Nigeria: A cross-sectional and analytical study. Int Breastfeed J. 2014;9(1):6.
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Hobbs AJ, Mannion CA, McDonald SW, Brockway M, Tough SC. The impact of caesarean section on breastfeeding initiation, duration and difficulties in the first four months postpartum. BMC Pregnancy Childbirth. 2016;16(1):90.
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32
Nagra S, Gilani A. Variations in infant feeding practices in Pakistan with socioeconomic stratification. J Trop Pediatr. 1987;33(2):103–6.
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Olang B, Heidarzadeh A, Strandvik B, Yngve A. Reasons given by mothers for discontinuing breastfeeding in Iran. Int Breastfeed J. 2012;7(1):7.
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Chandhiok N, Singh KJ, Sahu D, Singh L, Pandey A. Changes in exclusive breastfeeding practices and its determinants in India, 1992-2006: Analysis of national survey data. Int Breastfeed J. 2015;10(34).23.
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Amin T, Hablas H, Al Qader AA. Determinants of initiation and exclusivity of breastfeeding in al Hassa, Saudi Arabia. Breastfeed Med. 2011;6(2):59–68.
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Yeneabat T, Belachew T, Haile M. Determinants of cessation of exclusive breastfeeding in Ankesha Guagusa Woreda, Awi Zone, Northwest Ethiopia: a cross-sectional study. BMC Pregnancy Childbirth. 2014;14:262.
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Khasawneh W, Khasawneh AA. Predictors and barriers to breastfeeding in north of Jordan: could we do better? Int Breastfeed J. 2017 Dec;12(1).13.
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Tiwari R, Mahajan PC, Lahariya C. The determinants of exclusive breast feeding in urban slums: a community based study. J Trop Pediatr. 2009;55(1):49–54.
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Ogunlesi TA. Maternal socio-demographic factors influencing the initiation and exclusivity of breastfeeding in a Nigerian semi-urban setting. Matern Child Health J. 2010;14(3):459–65.
40
Khanal V, Lee AH, Karkee R, Binns CW. Postpartum Breastfeeding Promotion and Duration of Exclusive Breastfeeding in Western Nepal. Birth. 2015;42(4):329–36.
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Li R, Fein SB, Chen J, Grummer-Strawn LM. Why mothers stop breastfeeding: Mothers’ self-reported reasons for stopping during the first year. Pediatrics. 2008;122(SUPPL. 2):S69-76.
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Hazir T, Akram D-S, Nisar Y Bin, Kazmi N, Agho KE, Abbasi S, et al. Determinants of suboptimal breast-feeding practices in Pakistan. Public Health Nutr. 2012;16(4):659–72.
43
Hmone MP, Li M, Agho K, Alam A, Dibley MJ. Factors associated with intention to exclusive breastfeed in central women’s hospital, Yangon, Myanmar. Int Breastfeed J. 2017;12(1):1–12.
44
Dorgham LS, Hafez SK, Kamhawy HE, Hassan WB, Dorgham LS. Assessment of Initiation of Breastfeeding, Prevalence of Exclusive Breast Feeding and Their Predictors in Taif, KSA. Life Sci J. 2014;11(1):1–9.
45
Yılmaz E, Yılmaz Z, Isık H, Gultekın IB, Timur H, Kara F, et al. Factors Associated with Breastfeeding Initiation and Exclusive Breastfeeding Rates in Turkish Adolescent Mothers. Breastfeed Med. 2016;11(6):315–20.
46
Yeneabat et al 2014. Determinants of cessation of exclusive breastfeeding in Ankesha Guagusa Woreda , Awi Zone , Northwest Ethiopia : a cross-sectional study Determinants of cessation of exclusive breastfeeding in Ankesha Guagusa Woreda , Awi Zone , Northwest Ethiopia : a cro. BMC Pregnancyand childbirth. 2014;(August 2016):1–13.
47
Dun-Dery EJ, Laar AK. Exclusive breastfeeding among city-dwelling professional working mothers in Ghana. Int Breastfeed J. 2016;11(1):23.
48
Ogbo FA, Eastwood J, Page A, Arora A, McKenzie A, Jalaludin B, et al. Prevalence and determinants of cessation of exclusive breastfeeding in the early postnatal period in Sydney, Australia. Int Breastfeed J. 2017;12:16.
49
do Nascimento MBR, Reis MAM, Franco SC, Issler H, Ferraro AA, Grisi SJFE. Exclusive breastfeeding in southern Brazil: prevalence and associated factors. Breastfeed Med. 2010;5(2):79–85.
50
ORIGINAL_ARTICLE
The effect of Maternal Vitamin D Deficiency on Increased Risk for Hyperbilirubinemia in Term Newborns
BackgroundNeonatal jaundice is prevalent, and the presence of hyperbilirubinemia frequently requires medical attention and hospital readmission. The aim of the present study was to determine the effect of maternal vitamin D deficiency on increased risk for hyperbilirubinemia in term newborns.Materials and MethodsThis cross-sectional study was conducted on all pregnant women with gestational age of 38-42 weeks from southwestern Iran who referred to Hafez Hospital affiliated to Shiraz University of Medical Sciences, Shiraz, Iran, from March 2018 to August 2018. Serum 25-hydroxyvitamin D was measured from 300 included pregnant women during birth time. The level of bilirubin was measured in their newborns at 3rd to 5th days of life. The obtained data were analyzed using SPSS software version 22.0.ResultsThe level of 25-hydroxyvitamin D was low in 277 (92.3%) pregnant women. Hyperbilirubinemia was detected in 38 (12.6%) newborns at the 3rd to 5th days of life. Maternal vitamin D during pregnancy showed a significant correlation with the levels of bilirubin in newborns (r= - 0.458, P<0.001). ConclusionThe results of this study showed that maternal vitamin D deficiency could be associated with the increased risk for neonatal hyperbilirubinemia.
https://ijp.mums.ac.ir/article_13846_19f13e210f17ce5afd60a144a094fe00.pdf
2020-04-01
11141
11147
10.22038/ijp.2019.42133.3548
Hyperbilirubinemia
Jaundice
mothers
Newborns
Vitamin D deficiency
Zahra
Zia
ziazahraa@yahoo.com
1
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Zahra
Hashemi
hashemiz@sums.ac.ir
2
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Mozhgan
Moghtaderi
moghtadery@sums.ac.ir
3
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
LEAD_AUTHOR
Naser
Honar
honarn@sums.ac.ir
4
Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Forough
Saki
sakif@sums.ac.ir
5
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Ullah S, Rahman K, Hedayati M. Hyperbilirubinemia in Neonates: Types, Causes, Clinical Examinations, Preventive Measures and Treatments: A Narrative Review Article. Iran J Public Health. 2016; 45(5):558-68.
1
Allen D. Neonatal jaundice. Nurs Child Young People. 2016; 8; 28(6):11.
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Bhutani VK, Johnson L, Sivieri EM. Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns. Pediatrics 1999; 103:6e14.
3
Mojtahedi SY, Izadi A, Seirafi G, Khedmat L, Tavakolizadeh R. Risk Factors Associated with Neonatal Jaundice: A Cross-Sectional Study from Iran. Open Access Maced J Med Sci. 2018; 11; 6(8):1387-93.
4
Olusanya BO, Kaplan M, Hansen TWR. Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health. 2018; 2(8):610-20.
5
Porter ML, Dennis BL. Hyperbilirubinemia in the term newborn. Am Fam Physician. 2002; 15; 65(4):599-606.
6
Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, et al. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. Afr J Prim Health Care Fam Med. 2018; 10(1):e1-e6.
7
Kirk JM. Neonatal jaundice: a critical review of the role and practice of bilirubin analysis. Ann Clin Biochem. 2008; 45(Pt 5):452-62.
8
Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011; 86(1):50-60.
9
Abbasian M, Chaman R, Amiri M, et al. Vitamin D deficiency in pregnant women and their neonates. Glob J Health Sci. 2016; 8(9): 83–90.
10
Kozeta Miliku, Anna Vinkhuyzen, Laura M. E. Blanken, John J. McGrath, Darryl W. Eyles, Thomas H. Burne, et al. Maternal vitamin D concentrations during pregnancy, fetal growth patterns and risks of adverse birth outcomes. Am J Clin Nutr. 2016; 103(6): 1514–22.
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Mutgi K, Koo J. Update on the role of systemic vitamin D in atopic dermatitis. Pediatr Dermatol. 2013; 30(3):303-7.
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Gamal TS, Madiha AS, Hanan MK, Abdel-Azeem ME, Marian GS. Neonatal and maternal 25-OH vitamin D serum levels in neonates with early-onset sepsis. Children (Basel). 2017; 9; 4(5). pii: E37.
13
Bouillon R, Carmeliet G. Vitamin D insufficiency: Definition, diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2018; 32(5):669-84.
14
Aletayeb SM, Dehdashtiyan M, Aminzadeh M, Malekyan A, Jafrasteh S. Comparison between maternal and neonatal serum vitamin D levels in term jaundiced and nonjaundiced cases. J Chin Med Assoc. 2016; 79(11):614-7.
15
Mutlu M, Çayir A, Çayir Y, €Ozkan B, Aslan Y. Vitamin D and hyperbilirubinaemia in neonates. HK J Paediatr 2013; 18:77-81.
16
Najib KS, Saki F, Hemmati F, Inaloo S. Incidence, risk factors and causes of severe neonatal hyperbilirubinemia in the South of iran (fars province). Iran Red Crescent Med J. 2013; 15(3):260-3.
17
Ambalavanan N, Carlo WA. Jaundice and Hyperbilirubinemia in the Newborn. In: Kliegman RM, Stanton BF, Schor NF, et al, editors. Nelson Textbook of Pediatrics. 19th ed. Philadelphia: Elsevier Saunders; 2011: p. 606- 7.
18
Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc. 2010;85(8):752–8.
19
Fong J, Khan A. Hypocalcemia: updates in diagnosis and management for primary care. Can Fam Physician. 2012;58(2):158–62.
20
Mehrpisheh S, Memarian A, Mahyar A, Valiahdi NS. Correlation between serum vitamin D level and neonatal indirect hyperbilirubinemia. BMC Pediatr. 2018; 26; 18(1):178.
21
Sarici SU, Serdar MA, Korkmaz A, Erdem G, Oran O, Tekinalp G, et al. Incidence, course, and predition of hyperbilirubinemia in near-term and term newborns. Pediatrics. 2004; 113(4):775-80.
22
Young Infants Clinical Signs Study Group. Clinical signs that predict severe illness in children under age 2 months: a multicentre study. Lancet. 2008; 12; 371(9607):135–42.
23
Bhutani VK. Editorial: building evidence to manage newborn jaundice worldwide. Indian J Pediatr. 2012; 79(2):253–5.
24
Amoozegar V, Mirshakeri V, PaishvaN Prevalence of Glucose-6-Phosphate Dehydrogenase Deficiency among Male Donors in Shiraz, Southern Iran. Iran J Med Sci. 2005; 30(2):94–6.
25
Javaid MK, Crozier SR, Harvey NC, Gale CR, Dennison EM, Boucher BJ, et al. Maternal vitamin D status during pregnancy and childhood bone mass at 9 years: a longitudinal study. Lancet. 2006; 7; 367(9504):36-43.
26
Van der Meer I, Karamali N, Boeke A. High prevalence of vitamin D deficiency in pregnant non‐Western women in The Hague, Netherlands. Am J Clin Nutr 2006;84(2):350-3
27
Bassir M, Laborie S, Lapillonne A, Claris O, Chappuis MC, Salle BL.Vitamin D deficiency in Iranian mothers and their neonates: a pilot study. Acta Paediatr. 2001; 90(5):577-9.
28
Scholl TO, Chen X. Vitamin D intake during pregnancy: association with maternal characteristics and infant birth weight. Early Hum Dev. 2009; 85(4):231-34.
29
Kumaratne M, Early G, Cisneros J. Vitamin D deficiency and association with body mass index and lipid levels in Hispanic American adolescents. Glob Pediatr Health. 2017; 4: 2333794X17744141.
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DeLuca HF. The control of calcium and phosphorus metabolism by the vitamin D endocrine system. Ann N Y Acad Sci. 1980; 355:1-17.
31
Shaheen S, Noor SS, Barakzai Q. Serum alkaline phosphatase screening for vitamin D deficiency states. J Coll Physicians Surg Pak. 2012; 22(7):424-7.
32
ORIGINAL_ARTICLE
Acute Respiratory Tract Infection in Children under Five- Year; Study of Prevalence, Risk Factors and Outcome in Minia University Children’s Hospital, Egypt
BackgroundAcute respiratory infection is still the leading cause of morbidity and mortality in children under five in many countries. We aimed to assess the incidence and risk factors predicting the outcome of Acute Respiratory Infection (ARI). Materials and MethodsThis is a hospital-based case study conducted at Minia University Children’s Hospital, Egypt from December 2016 until December 2018. Children from 2 months till five years and presented by criteria of ALRI according to WHO criteria were included in the study and evaluated for clinical presentation, risk factors and outcome. Routine investigations such as CBC, CRP and chest X-ray were done for all cases. ResultsOut of 586 children admitted to pulmonology unit only 215 (36.7%) fulfill the WHO criteria of ARI program, with higher incidence among infants below 6 months (48.8%) and male children (58.6%), majority of children had anemia (87%), and PEM (60%), according to WHO criteria we found that 18.6% of cases had pneumonia and 49.7% of cases had severe pneumonia. Need of change in antibiotics, duration of stay and outcomes were significantly associated in relation to pneumonia severity (p=0.04, p=0.03 and p=0.01, respectively); while need for oxygen therapy was highly significant (p=0.001) and 15% required mechanical ventilation. Lobar pneumonia (32.5%) was the most common diagnosis and sepsis was the most frequent cause of death and mortality rate was 9.3% (n=20). ConclusionYoung age, malnutrition and poor socioeconomic status play an important role in in the morbidity; effective management of malnutrition, improving the living standards and proper health education programs, can reduce mortality from respiratory infection in children, ARI burden and severity.
https://ijp.mums.ac.ir/article_13691_c1d371e8771c932e79b8c10522713bbf.pdf
2020-04-01
11149
11157
10.22038/ijp.2019.42502.3567
Acute Respiratory Infection
Children
Outcome
Risk factors
Abdelhakeem
Abdel Mohsen
aboueyad1@yahoo.com
1
Department of Pediatrics, El-Minia University, Egypt.
LEAD_AUTHOR
Mohammed
Amin
mohammedamin@yahoo.com
2
Departments Radiology, El-Minia University, Egypt .
AUTHOR
Rasha
Yousef
rashayousef405@yahoo.com
3
Departments of Clinical Pathology, El-Minia University, Egypt.
AUTHOR
1. Nair H, Simoes EA, Rudan I, Gessner BD, Azziz-Baumgartner E, et al. (2013) Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysis. Lancet 381: 1380–90.
1
Walker CL, Rudan I, Liu L, Nair H, Theodoratou E, et al. (2013) Global burden of childhood pneumonia and diarrhoea. Lancet 381: 1405–16.
2
Liu L, Johnson HL, Cousens S, Perin J, Scott S, et al. (2012) Global, regional, and national causes of child mortality: An updated systematic analysis for 2010 with time trends since 2000. Lancet 379:2151–61.
3
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, et al. (2012) Global and regional mortality from235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burdenof Disease Study 2010. Lancet 380: 2095–128.
4
Jackson S, Mathews KH, Pulanic D, Falconer R, Rudan I, et al. (2013) Risk factors for severe acute lower respiratory infections in children: a systematic review and meta-analysis. Croat Med J 54: 110–21.
5
Wonodi CB, Deloria-Knoll M, Feikin DR, DeLuca AN, Driscoll AJ, et al. (2012) Evaluation of risk factors for severe pneumonia in children: The pneumonia etiology research for child health study. Clinical Infectious Diseases 54 Suppl 2: S124–S131).
6
Mertz D, Kim TH, Johnstone J, Lam PP, Science M, et al. (2013) Populations at risk for severe or complicated influenza illness: systematic review and meta-analysis. BMJ 347: f5061. doi: 10.1136/bmj.f5061 PMID: 23974637
7
Lozano JM (2001) Epidemiology of hypoxaemia in children with acute lower respiratory infection. Int J Tuberc Lung Dis 5: 496–504. PMID: 11409574
8
El-Zanaty F, Ann W. Egypt Demographic and Health Survey 2008. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International. 2009.
9
Montasser N, Helal R and Rezq R. Assessment and classification of acute respiratory tract infections among Egyptian rural children. British Journal of Medicine and Medical Research. 2012;2(2):216-27.
10
11-Daniel E Roth,a Laura E Caulfield,a Majid Ezzatib & Robert E Black; Prevention and control of childhood pneumonia Bulletin of the World Health Organization | May 2008, 86 (5)
11
12- WHO. Pneumonia. 2016. Available at www.who.int/mediacentre/factsheets/fs331/en/
12
Lamberti L, Zakarija-Grkoviç I, Fischer Walker CL, Theodoratou E, Nair H, et al. (2013) reducing the risk of pneumonia morbidity and mortality in children under two: a systematic literature review and meta-analysis. BMC Public Health 13: S18.
13
14- Srinivasa S, Shruthi Patel S et al. A study on distribution pattern of lower respiratory tract infections in children under 5 years in a tertiary care centre Int J Contemp Pediatr. 2018 Mar;5(2):456-461
14
15- Paramesh H. Epidemiology of asthma in India. Indian J Pediatr. 2002;69(4):309-12.
15
Udaya K, Murteli VB, Desai A. Clinical profile of children with pneumonia admitted at tertiary care hospital, Belgaum: a prospective study. Indian J Child Health. 2017;4(3):352-5.
16
Savitha MR, Nandeeshwara SB, Kumar PMJ, Ul-Haque F, Raju CK. Modifiable risk factors for acute lower respiratory tract infections. Indian J Pediatr. 2007;74: 477-82.
17
Broor S, Pandey RM, Ghosh M, Maitreyi RS, Lodha R, Singhal TS, et al. Risk factors for acute lower respiratory tract infections. Indian Pediatr. 2001;38:1361-7.
18
19- sehgal VK, Mahesh RMU, Kandat J, Ponugoti M. Clinical study of lower respiratory tract infection in children attending a tertiary care hospital. Int J Contemp Pediatr. 2017;4:1733-8.
19
20-Drummond M, Pellegrin MC, Becker G, Lazzerini M, Risk factor for mortality from acute lower respiratory tract infection in children under 5 five years of age in low and middle-income countries: a systemic review and meta-analysis of observational studies. Plos One. 2015:10(1):e0116380.
20
21- El-Zanaty F and Associates. Egypt Demographic and Health Survey 2014. Cairo, Egypt: Ministry of Health, El-Zanaty and Associates, and Macro International. 2015
21
22-Khalek EMA, Abdel-Salam DM. Acute respiratory tract infections in children under 5 years of age in Upper Egypt. Int J Community Med Public Health 2016;3:1161-6.
22
24-Kumar AMK, Badakali AV, Mirji G, Vanaki RN, Pol R. Clinical profile and outcome of acute lower respiratory tract infection in children aged between 2 months to 5 years. Int J Contemp Pediatr. 2017;4:105-9.
23
25-Kabra SK, Verma IC. Acute lower respiratory tract infection. The Forgotten Pandemic. 1999;66:873-5.
24
26-. Ujunwa FA, Ezeonu CT. Risk factors for acute respiratory tract infections in under-five children in Enugu Southeast Nigeria. Ann Med Health Sci Res. 2014;4(1):95-99.
25
27-Yousif T, Khaleq B. Epidemiology of acute respiratory tract infections (ARI) among children under five years old attending Tikrit General Teaching Hospital. Middle East Journal of Family Medicine. 2006;14(3):148-52.
26
28-Reddaiah VP, Kapoor SK. Acute respiratory infections in under five: experience at comprehensive rural health services project hospital Ballabgarh. Indian J Community Med. 1995;20:1-4.
27
29-DukeT Christi MJ, Tebruegge M, la Vincent S, Raham SM, Pneumonia in severely malnourished children in developing countries-mortality risk, aetiology and validity of WHO clinical signs: A systematic review. Trop Med Int Health. 2009;14:1173e-89
28
30-Mishra AS, Iyer CR, Gornale VK, Katwe N, Sushma S, Harsha PJ, et al. Clinical profile of acute lower respiratory tract infections in children between 2 months to 5 years. J Evidence Based Med Healthcare. 2015;2(35):5426-31.
29
ORIGINAL_ARTICLE
Evaluation of QRS, QTC, JTC Intervals in Congenital Heart Disease with Pulmonary
BackgroundPulmonary hypertension (PH) in congenital heart disease (CHD) affects the patient prognosis. QRS and QTC intervals prolongation in ECG may exaggerate life-threatening dysrhythmia in these patients. We aimed to investigate the correlation between QRS, QTC and JTC intervals prolongation in ECG with PH in CHD children. Materials and MethodsIn a cross-sectional study that was performed in pediatric cardiology clinic of Besat hospital (Hamadan, Iran), during 2016-2018, patients with CHD and PH as case group (n=40) were compared to simple CHD patients without any evidence of PH as control group (n=40). Based on Pulmonary Artery (PA) to systemic pressure ratio, lower than 1/2 was considered as mild PH and equal and more than 1/2 was considered severe PH; then QRS, QTC, JTC intervals in ECG and RVMPI, TAPSE in echocardiography were compared between case (PH group), and control groups. We also compared these ECG and echocardiographic findings between mild and severe PH group.ResultsThere was significant difference in QRS (p=0.005), and QTC (p=0.036) intervals between two groups, but there was not any significant difference between JTC interval between two groups (p=0.714). Of 40 patients with PH, 19 subjects were in the mild PH group and 21 subjects were in severe PH group, in which nine patients had irreversible PH or Eisenmenger syndrome. QTC (p
https://ijp.mums.ac.ir/article_15363_ba018d365f8d240a59db8a0dd8328fcc.pdf
2020-04-01
11159
11167
10.22038/ijp.2020.47755.3862
Children
congenital heart disease
JTC interval
QTC interval
Asadolah
Tanasan
asadolahtanasan@gmail.com
1
Assistant Professor of Pediatrics Cardiology, Department of Pediatrics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran.
LEAD_AUTHOR
Ziba
Hasani
mohamadmehdipour@ymail.com
2
Medical Student, Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran
AUTHOR
Mehdi
Moradi
mmorad341@yahoo.com
3
Associate Professor of Cardiology, Farshchian Heart Center, Hamadan University of Medical Sciences, Hamadan, Iran.
AUTHOR
FarzanehEsna
Ashari
esnaashari_f@umsha.ac.ir
4
Associate Professor of community medicine, Department of community medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
AUTHOR
Haworth SG. Pulmonary vascular disease in different types of congenital heart disease. Implications for interpretation of lung biopsy findings in early childhood. Heart. 1984;52(5):557-71.
1
Kafian Atary S, Mirshahi A, Amouzeshi A, Ramezani A, Bahman B, Hasanzadeh Tahery M, et al. Epidemiologic Study of Congenital Heart Diseases and Its Related Factors in Children Referred to the Pediatric Cardiac Clinic of Birjand University of Medical Sciences during 2015-2017. International Journal of Pediatrics. 2019.
2
Gatzoulis MA. Pulmonary vascular disease in adults with congenital heart disease. Circulation. 2007.
3
Wood P. The eisenmenger syndrome: Or pulmonary hypertension week reversed central shunt. American Journal of Cardiology. 1972;30(2):172-4.
4
Folino A, Bobbo F, Schiraldi C, Tona F, Romano S, Buja G, et al. Ventricular arrhythmias and autonomic profile in patients with primary pulmonary hypertension. Lung. 2003;181(6):321-8.
5
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Ghandi Y, Sharifi M, Alinejad S, Arjmand A, Nikdel S. Atrial and Ventricular Electrocardiographic Dromotropic Disturbances in Down Syndrome Patients with Structurally Normal Heart: A Cross-Sectional Study. International Journal of Pediatrics. 2018;6(3):7345-51.
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10
Nomura M, Nakaya Y, Miyajima H, Nada T, Morishita S, Saito K, et al. Clinical application of QT dispersion on ventricular hypertrophy using magnetocardiogram. 2007.
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Okin PM, Devereux RB, Howard BV, Fabsitz RR, Lee ET, Welty TK. Assessment of QT interval and QT dispersion for prediction of all-cause and cardiovascular mortality in American Indians. Circulation. 2000.
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Yankelson L, Hochstadt A, Sadeh B, Pick B, Finkelstein A, Rosso R, et al. New formula for defining “normal” and “prolonged” QT in patients with bundle branch block. Journal of electrocardiology. 2018;51(3):481-6.
13
Zareba W, McNitt S, Polonsky S, Couderc J-P. JT interval: What does this interval mean? Journal of electrocardiology. 2017;50(6):748-51.
14
Piao L, Fang Y-H, Cadete VJ, Wietholt C, Urboniene D, Toth PT, et al. The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle. Journal of molecular medicine. 2010;88(1):47-60.
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Hong-liang Z, Qin L, Zhi-hong L, Zhi-hui Z, Chang-ming X, Xin-hai N, et al. Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension. Wiener Klinische Wochenschrift. 2009;121(9-10):330-3.
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Rich JD, Thenappan T, Freed B, Patel AR, Thisted RA, Childers R, et al. QTc prolongation is associated with impaired right ventricular function and predicts mortality in pulmonary hypertension. International journal of cardiology. 2013;167(3):669-76.
17
Saleh A, Shabana A, El Amrousy D, Zoair A. Predictive value of P-wave and QT interval dispersion in children with congenital heart disease and pulmonary arterial hypertension for the occurrence of arrhythmias. Journal of the Saudi Heart Association. 2019;31(2):57-63.
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Akgül F, Seyfeli E, Melek İ, Duman T, Seydaliyeva T, Gali E, et al. Increased QT dispersion in sickle cell disease: effect of pulmonary hypertension. Acta Haematologica. 2007;118(1):1-6.
19
Taooka Y. Qtc Prolongation in Pulmonary Hypertension Cases Due to Lung Diseases. EC Pulmonology and Respiratory Medicine. 2016;2:67-73.
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EMAN A, F. S, SAMIA M, RAGHDA G, EL-SHEIKH. The Correlation between QT Dispersion and Severity of Pulmonary Valve Stenosis. medical journal cairo university. 2018;86(1):341-7.
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Tuncer M, Gunes Y, Guntekin U, Aslan S, Gumrukcuoglu HA, Eryonucu B, et al. Association of increased QTc dispersion and right ventricular hypertrophy. Medical Science Monitor. 2008;14(2):CR102-CR5.
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Semizel E, Alehan D, Özer S, Serdar MA. Eisenmenger syndrome: identifying the clues for arrhythmia. Anatolian Journal of Cardiology/Anadolu Kardiyoloji Dergisi. 2008;8(1).
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Diller G-P, Dimopoulos K, Broberg CS, Kaya MG, Naghotra US, Uebing A, et al. Presentation, survival prospects, and predictors of death in Eisenmenger syndrome: a combined retrospective and case–control study. European heart journal. 2006;27(14):1737-42.
24
Ece I, Üner A, Ballı Ş, Oflaz MB, Kibar AE, Sal E. P-wave and QT interval dispersion analysis in children with Eisenmenger syndrome. Turk Kardiyoloji Dernegi arsivi: Turk Kardiyoloji Derneginin yayin organidir. 2014;42(2):154-60.
25
Şap F, Karataş Z, Altin H, Alp H, Oran B, Baysal T, et al. Dispersion durations of P-wave and QT interval in children with congenital heart disease and pulmonary arterial hypertension. Pediatric cardiology. 2013;34(3):591-6.
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Tsai SF, Houmsse M, Dakhil B, Augostini R, Hummel JD, Kalbfleisch SJ, et al. QTc compared to JTc for monitoring drug-induced repolarization changes in the setting of ventricular pacing. Heart rhythm. 2014;11(3):485-91.
27
Teodorescu C, Reinier K, Uy-Evanado A, Navarro J, Mariani R, Gunson K, et al. Prolonged QRS duration on the resting ECG is associated with sudden death risk in coronary disease, independent of prolonged ventricular repolarization. Heart rhythm. 2011;8(10):1562-7.
28
Berul CI, Sweeten TL, Dubin AM, Shah MJ, Vetter VL. Use of the rate-corrected JT interval for prediction of repolarization abnormalities in children. The American journal of cardiology. 1994;74(12):1254-7.
29
Punn R, Lamberti JJ, Balise RR, Seslar SP. QTc prolongation in children following congenital cardiac disease surgery. Cardiology in the Young. 2011;21(4):400-10.
30
Tanasan A, Shabanian R, Dadkhah M, Mazloumi E. Accuracy of Myocardial Performance Index in Diagnosis of Right Ventricular Dysfunction after Surgical Correction of Tetralogy of Fallot: A Narrative review. Journal of Pediatrics Review. 2019;7(3):161-8.
31
Moladoust H, Salari A, Voshtani SH. Evaluation of brain natriuretic peptide, tumor necrosis factor and interleukin-6 plasma levels in infants and children with congenital heart disease. International Journal of Pediatrics. 2018;6(8):8031-7.
32
Noori NM, Yazdanparast A, Nakhaee Moghaddam M, Teimouri A. Evaluation of Serum NT-Pro Brain Natriuretic Peptide Levels in Neonates with Respiratory Distress. International Journal of Pediatrics. 2018;6(6):7769-80.
33
ORIGINAL_ARTICLE
Effects of Curcumin Supplementation on Quality of Life of Cystic Fibrosis Patients
Background: Cystic fibrosis (CF) is one of the most common genetic disorders in children. CF patients are susceptible to chronic lung infections and malabsorption. Although patient longevity is increased by multidisciplinary care, patients still suffer from respiratory failure and low quality of life. In this situation, CF patients tend to use complementary treatments. To the best of our knowledge there is no research about curcumin supplementation in CF patients; thus, we decided to investigate the effects of curcumin supplementation on anthropometric indices, and quality of life in children with cystic fibrosis.Materials and MethodsThis randomized control-controlled clinical study was conducted in Tabriz University of Medical Sciences, Iran. Forty CF patients were randomly sorted into intervention (n=20), and control (n=20) groups. Patients received 3 curcumin nanoparticles (80 mg; total dose 240 mg/d) for six consecutive months. Before and after intervention, height and weight were measured and quality of life of patients was evaluated by the Pediatric Quality of Life Inventory (PedsQL) 4.0 (CITE). Results: After intervention, the percentage of weight changes showed a significant increase in the curcumin group compared to the control group (7.48±4.68 vs. 4.15±4.68 kg, p=0.03). Following the intervention, only the percentage of change in emotional functioning scores was significant (p=0.01). Subjects in the curcumin group showed a trend towards more improvement in terms of percentage change in physical functioning (19.28±31.65 vs. 15.24±47.14), and school functioning scores (40.96±42.93 vs 23.90±14.82) compared with the control group. ConclusionOur findings suggest that curcumin may be a useful, inexpensive, and safe supplement in combination with conventional therapy to improve body weight in CF children.
https://ijp.mums.ac.ir/article_13902_0504c81a0b301b363c89d3c6a6c9a3d5.pdf
2020-04-01
11169
11176
10.22038/ijp.2019.42990.3602
anthropometrics indices
Curcumin
Cystic fibrosis
Quality of life
Mandana
Rafeey
profrafeey@gmial.com
1
MD, Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz Cystic Fibrosis Registry, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Zeinab
Nikniaz
znikniaz@hotmail.com
2
PhD, Assistant Professor, Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Fatemeh
FarshiRadvar
radvarfa14@gmail.com
3
MSc, Nutrition Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Ziba
Sameni
zibasameni@yahoo.com
4
MD, Department of Pediatrics, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Elnaz
Faramarzi
elnazfaramarzi849@gmail.com
5
Ph.D, Assistant Professor, Liver and Gastrointestinal Diseases Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran.
LEAD_AUTHOR
Foundation CF. Patient Registry Report. Bethesda,
1
MD: Cystic Fibrosis Foundation. Accessed October 26, 2010.;http://www.cff.org/research/
2
clinicalresearch/patientregistryreport.
3
Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, et al. Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell. 1998;95(7):1005-15.
4
Haq IJ GM, Garnett JP, Ward C, Brodlie M. Airway surface liquid homeostasis in cystic fibrosis: Pathophysiology and therapeutic targets. Thorax. 2016;71:3.
5
Bradbury N. Cystic Fibrosis. In: Bradshaw, RD.; Stahl, P., editors. The encyclopedia of cell biology. Elsevier. 2015:10.
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Cantin AM. Potential for antioxidant therapy of cystic fibrosis. Current Opin Pulmonary Med. 2004;10(6):531-6.
7
Chmiel JF, Konstan MW. Anti-inflammatory medications for cystic fibrosis lung disease. Treatment Respiratory Med. 2005;4(4):255-73.
8
Tanase A, Zanni R. The use of complementary and alternative medicine among pediatric cystic fibrosis patients. J Alter Complement Med. 2008;14(10):1271-3.
9
Borowitz D, Parad R, Sharp J, Sabadosa K, Robinson K, Rock M, et al. Cystic Fibrosis Foundation. Cystic Fibrosis Foundation practice guidelines for the management of infants with cystic fibrosis transmembrane conductance regulator-related metabolic syndrome during the first two years of life and beyond. J Pediatr. 2009;155(suppl 6):S106-16.
10
Cohen-Cymberknoh M, Shoseyov D, Kerem E. Managing cystic fibrosis: strategies that increase life expectancy and improve quality of life. Am J Respir Crit Care Med. 2011;183(11):1463-71.
11
Martin C, Hamard C, Kanaan R, Boussaud V, Grenet D, Abély M, et al. Causes of death in French cystic fibrosis patients: the need for improvement in transplantation referral strategies! J Cystic Fibrosis. 2016;15(2):204-12.
12
Abdulhamid I, Beck F, Millard S, Chen X, Prasad A. Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis. Pediatric Pulmonol 2008;43(3):281-7.
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Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Alter Med Rev. 2009;14(2).
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Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013;15(1):195-218.
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Reverri EJ, Morrissey BM, Cross CE, Steinberg FM. Inflammation, oxidative stress, and cardiovascular disease risk factors in adults with cystic fibrosis. Free Radical Biol Med. 2014;76:261-77.
16
Khdair SA, Abdulridha MK, Fatah MA. Effect of Curcumin Supplement on Pulmonary Functions, Total and Differential White Blood Cell Count, Serum Level of Leptin and Body Mass Index in a Sample of Iraqi Patients with Chronic Bronchial Asthma. AJPS. 2019;19(2):47-58.
17
Chaudhary N, Ueno-Shuto K, Ono T, Ohira Y, Watanabe K, Nasu A, et al. Curcumin down-regulates toll-like receptor-2 gene expression and function in human cystic fibrosis bronchial epithelial cells. Biol Pharmaceutical Bull. 2019:b18-00928.
18
Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006;4(12):1502-6.
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Zhang X, Chen Q, Wang Y, Peng W, Cai H. Effects of curcumin on ion channels and transporters. Frontiers in physiology. 2014;5:94.
20
Berger AL, Randak CO, Ostedgaard LS, Karp PH, Vermeer DW, Welsh MJ. Curcumin stimulates cystic fibrosis transmembrane conductance regulator Cl–channel activity. J BiolChem. 2005;280(7):5221-6.
21
Varni JW, Burwinkle TM, Seid M, Skarr DJAp. The PedsQL™ 4.0 as a pediatric population health measure: feasibility, reliability, and validity. Ambulat Pediatr. 2003;3(6):329-41.
22
Varni JW, Seid M, Kurtin PSJMc. PedsQL™ 4.0. Reliability and validity of the Pediatric Quality of Life Inventory™ Version 4.0 Generic Core Scales in healthy and patient populations. Med Care. 2001;39(8):800-12.
23
Amiri P, Eslamian G, Mirmiran P, Shiva N, Jafarabadi MA, Azizi F. Validity and reliability of the Iranian version of the Pediatric Quality of Life Inventory™ 4.0 (PedsQL™) Generic Core Scales in children. Health Quality Life Outcome. 2012;10(1):3.
24
Amiri P, Ardekani EM, Jalali-Farahani S, Hosseinpanah F, Varni JW, Ghofranipour F, et al. Reliability and validity of the Iranian version of the Pediatric Quality of Life Inventory™ 4.0 Generic Core Scales in adolescents. Qulaity Life Res. 2010;19(10):1501-8.
25
Dey I, Shah K, Bradbury NA. Natural compounds as therapeutic agents in the treatment cystic fibrosis. J Genetic Syndromes Gene Therapy. 2016;7(1).
26
Song Y, Sonawane N, Salinas D, Qian L, Pedemonte N, Galietta LJ, et al. Evidence against the rescue of defective ΔF508-CFTR cellular processing by curcumin in cell culture and mouse models. J Biol Chem. 2004;279(39):40629-33.
27
He Z-Y, Shi C-B, Wen H, Li F-L, Wang B-L, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest. 2011;29(3):208-13.
28
Olveira G, Olveira C, Acosta E, Espíldora F, Garrido-Sánchez L, García-Escobar E, et al. Fatty acid supplementation improves respiratory, inflammatory and nutritional parameters in adults with cystic fibrosis. Archiv Bronconeumología ((English Edition)). 2010;46(2):70-7.
29
Alipour M, Omri A, Suntres ZE. Ginseng aqueous extract attenuates the production of virulence factors, stimulates twitching and adhesion, and eradicates biofilms of Pseudomonas aeruginosa. Canad J Physiol Pharmacol. 2011;89(6):419-27.
30
ORIGINAL_ARTICLE
The Effect of Lavender Oil for Relief Painful Producer in Children and Infants: A Systematic Review
BackgroundTo manage the pain, one of the alternative methods entails the essential oils usage. Aim of this study is to give comprehensive information about the effect of lavender for aliavative painful producer in infants and children.Materials and MethodsA systematic search was conducted on English databases of Scopus, Medline, Cochrane Library, EMBASE and Web of Science up to the end of February 2019. Authors performed search without any time restrictions. Two authors independently performed search and assessed their quality.ResultsThe five studies (n=414 participants) were included. In the first study, the change of NIPS score was significantly lower in lavender than control groups. The duration of crying was 75.47 (60.675), and 105.22 (75.739) seconds in the lavender and the control groups, respectively, which was significantly different. In second study, aromatherapy with lavender was unable to change the VAS score (p=0.40); while heart rate decreased to a significance borderline level (p=0.0639). In the third study, significant differences in the mean SpO2, respiratory rate, and heart rate at different time points between the aromatherapy with lavender and the control groups in preschool children. In the fourth study, the lavender group exhibited lower NIPS score compared to the amniotic fluid and breast milk groups. In fifth study, 80 term infants were assigned into case (n=40), and control (n=40) groups, there was a significant difference in pain scores between the two groups, lavender and control.ConclusionThis study showed that the lavender as non-pharmacological effective way is effective to alleviate the blood sampling-related pain in infants and children, though it did not affect the duration of crying.
https://ijp.mums.ac.ir/article_13822_32e6458f7a1180b81e0d59a7160155c0.pdf
2020-04-01
11177
11185
10.22038/ijp.2019.42915.3593
Children
effects
Lavender
Infants
Pain
Majid
Sezavar
sezavardm@mums.ac.ir
1
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Reza
Ahmadi
2
Department of Emergency Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Hoda
Shojaei
3
Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mahdiye
Jafari
dr_mahdiye_jafari@yahoo.com
4
Department of Anesthesiology, Mashhad University of medical sciences, Mashhad, Iran.
AUTHOR
Iman
Hashemi
5
Department of Anesthesiology, Mashhad University of medical sciences, Mashhad, Iran.
AUTHOR
Ali Reza
Attaei Nakhaie
ataeina@mums.ac.ir
6
Department of pediatric and pediatric neurology, Ghaem Hospital, Mashhad, Mashhad University of medical science, Mashhad, Iran
LEAD_AUTHOR
Roozbeh
Nasibeh
7
Mother and Child Welfare Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
AUTHOR
Shahrzad
Zolala
8
Department of Nursing and Midwifery, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
AUTHOR
Farzane
Ashrafinia
9
Department of Nursing and Midwifery, Razi School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.
AUTHOR
Zahra
Khojastehfard
khojastehfz1992@gmail.com
10
School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Neshat H, Jebreili M, Seyyedrasouli A, Ghojazade M, Hosseini MB, Hamishehkar H. Effects of breast milk and vanilla odors on premature neonate's heart rate and blood oxygen saturation during and after venipuncture. Pediatrics & Neonatology. 2016;57(3):225-31.
1
Aghagoli S, Salimi A, Salimi M, Ghazavi Z, Marofi M, Mohammadbeigi A. Aromatherapy with rosa damascenes in apnea, bradycardia and Spo2 of preterm infants; a randomized clinical trial. International Journal of Pediatrics. 2016;4(6):1911-8.
2
Akcan E, Polat S. Comparative effect of the smells of amniotic fluid, breast milk, and lavender on newborns’ pain during heel lance. Breastfeeding Medicine. 2016;11(6):309-14.
3
Badiee Z, Asghari M, Mohammadizadeh M. The calming effect of maternal breast milk odor on premature infants. Pediatrics & Neonatology. 2013;54(5):322-5.
4
Małachowska B, Fendler W, Pomykała A, Suwała S, Młynarski W. Essential oils reduce autonomous response to pain sensation during self-monitoring of blood glucose among children with diabetes. Journal of Pediatric Endocrinology and Metabolism. 2016;29(1):47-53.
5
Bikmoradi A, Khaleghverdi M, Seddighi I, Moradkhani S, Soltanian A, Cheraghi F. Effect of inhalation aromatherapy with lavender essence on pain associated with intravenous catheter insertion in preschool children: A quasi-experimental study. Complementary therapies in clinical practice. 2017;28:85-91.
6
Razaghi N, Sadat Hoseini AS, Aemmi SZ, Mohebbi T, Boskabadi H. The effects of lavender scent on pain of blood sampling in term neonates. International Journal of Pediatrics. 2015;3(2.2):535-41.
7
Vaziri F. The Effect of Aromatherapy by Lavender Oil on Infant Vaccination Pain: a Double Blind Randomized Controlled Trial. Journal of caring sciences. 2019;8(1):17.
8
Moayedi M, Davis KD. Theories of pain: from specificity to gate control. Journal of neurophysiology. 2012;109(1):5-12.
9
Campbell TS, Johnson JA, Zernicke KA. Gate control theory of pain. Encyclopedia of Behavioral Medicine. 2013:832-4.
10
Çetinkaya B, Başbakkal Z. The effectiveness of aromatherapy massage using lavender oil as a treatment for infantile colic. International journal of nursing practice. 2012;18(2):164-9.
11
Jebreili M, Neshat H, Seyyedrasouli A, Ghojazade M, Hosseini MB, Hamishehkar H. Comparison of breastmilk odor and vanilla odor on mitigating premature infants' response to pain during and after venipuncture. Breastfeeding Medicine. 2015;10(7):362-5.
12
Sullivan RM, Toubas P. Clinical usefulness of maternal odor in newborns: soothing and feeding preparatory responses. Neonatology. 1998;74(6):402-8.
13
Goubet N, Strasbaugh K, Chesney J. Familiarity breeds content? Soothing effect of a familiar odor on full-term newborns. Journal of Developmental & Behavioral Pediatrics. 2007;28(3):189-94.
14
Sadathosseini AS, Negarandeh R, Movahedi Z. The effect of a familiar scent on the behavioral and physiological pain responses in neonates. Pain Management Nursing. 2013;14(4):e196-e203.
15
Nishitani S, Miyamura T, Tagawa M, Sumi M, Takase R, Doi H, et al. The calming effect of a maternal breast milk odor on the human newborn infant. Neuroscience Research. 2009;63(1):66-71.
16
Rattaz C, Goubet N, Bullinger A. The calming effect of a familiar odor on full-term newborns. Journal of Developmental & Behavioral Pediatrics. 2005;26(2):86-92.
17
Bikmoradi A, Seifi Z, Poorolajal J, Araghchian M, Safiaryan R, Oshvandi K. Effect of inhalation aromatherapy with lavender essential oil on stress and vital signs in patients undergoing coronary artery bypass surgery: A single-blinded randomized clinical trial. Complementary therapies in medicine. 2015;23(3):331-8.
18
ORIGINAL_ARTICLE
Usefulness of Serum NT-proBNP in Diagnosis of Generalized Seizures in Egyptian Children
BackgroundSeizures may occur in as many as 1% of children. The most urgent type of seizures is generalized tonic-clonic seizures (GTCS). N-terminal prohormone of brain natriuretic peptide (NT‐proBNP) has been considered as a promising biomarker in numerous acute illnesses. We aimed to evaluate usefulness of NT‐proBNP for diagnosis of generalized seizures in children.Materials and MethodsThis prospective case control study was conducted upon 80 children who were classified into four groups; Group I: included 20 patients with idiopathic generalized epileptic seizures. Group II: included 20 patients with focal epileptic seizures. Group III: included 20 patients with febrile seizures. Group IV: included 20 apparently healthy, age and sex matched children as a normal control. Complete blood count (CBC), blood chemistries, including random blood glucose, calcium, sodium, C-reactive protein (CRP) level, serum prolactin and NT‐proBNP were performed for all children.ResultsOur results revealed significant increase of both prolactin and NT‐proBNP in generalized epileptic and febrile seizure groups than in focal epileptic and control groups (p< 001). The ROC curve analysis showed NT‐proBNP, at a cut-off value of > 384 pg/ml, sensitivity (90 %), and specificity (70.2%) which was near the results of prolactin at a cut-off value> 25.9 ng/ml, and showed sensitivity (95.1%), and specificity (71.3%). ConclusionBased on the results, NT‐proBNP increase in generalized seizures either epileptic or febrile; and may be a promising marker to adjust the diagnosis of it at the emergency setting, when history and clinical presentation are equivocal.
https://ijp.mums.ac.ir/article_15362_b2a498af982728d3896023057d37cc39.pdf
2020-04-01
11187
11195
10.22038/ijp.2020.47471.3850
Children
N-terminal prohormone of brain natriuretic peptide
Prolactin
Seizures
Mohamed
Mahgoob
mohamed.mahgoub@mu.edu.eg
1
Lecturer of Pediatrics, Pediatric Department, Faculty of Medicine, Minia University, Egypt. Address: Mina University, Faculty of Medicine, Minia, Egypt.
LEAD_AUTHOR
Mahmoud
Moussa
mahmoussa78@yahoo.com
2
Lecturer of Clinical Pathology, Department of Clinical Pathology, Faculty of Medicine, Minia University, Egypt.
AUTHOR
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[4] Wahab A. Difficulties in Treatment and Management of Epilepsy and Challenges in New Drug Development. Pharmaceuticals (Basel).2010;3(7):2090–2110. doi:10.3390/ph3072090
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[5] Chaurasiya OS, Gupta P, Kaushik A, Yadav R. Usefulness of Serum Prolactin in Differentiating Epileptic and Pseudoseizures in Children. People’s Journal of Scientific Research.2013;6(1):29–32. https://pdfs.semanticscholar.org/1b98/1bbdde38534642e7abdeaa3ad2f7fcaa64b2.pdf
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[6] Tatlı B, Güler S. Non epileptic paroxysmal events in childhood. Turk Pediatri Ars.2010;52(2):59–65.
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[9] Jan SL, Lin SJ, Fu YC, Lin MC, Chan SC, Hwang B. Plasma B-type natriuretic
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peptide study in children with severe enterovirus 71 infection: a pilot study.
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Int J Infect Dis. 2013;17:e1166–71. doi:10.1016/j.ijid.2013.06.012.
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[13] Olalla J, Crespo E, De la Torre J, Sempere M, Del Arco A, Prada JL, et al.
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