ORIGINAL_ARTICLE
The Relationship between Severe Hyperbilirubinemia and Abnormal Auditory Brainstem Response in children
Abstract:Background : Hyperbilirubinemia is one of the most common cause of congenital sensory neuronal hearing loss. These patients are screened by auditory brainstem response (ABR) test at bilirubin levels higher than 1% of gestational weight. Aim: to determine whether hyperbilirubinemia less than 1% of gestational weight could induce hearing loss and abnormal auditory brainstem response (ABR).Methods: in this case control study the outcome of ABR test in children younger than 3 years old with a history of term delivery and hyperbilirubinemia (bilirubin level less than 1% of gestational weight) were compared with the control group without hyperbilirubinemia matched for age and sex.Results: Mean ABR amplitude (wave I, V) were significantly prolonged in neonates with jaundice compared with controls (P0.6% gestational weight was 2.25 with 95% CI (1.44-3.89 and p=0.02).Conclusion: Our study showed a relevant association between bilirubin levels less than 20 mg/dl and abnormal ABR.
https://ijp.mums.ac.ir/article_3086_b07b8b6cae7fbbf0738c86a728de1f5c.pdf
2014-09-01
5
10
10.22038/ijp.2014.3086
Keywords: Auditory brainstem response
Hearing Loss
Hyperbilirubinemia
Ali Asghar
Peyvandi
info@sinains.com
1
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Ali
Eftekharian
web@sinains.com
2
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Ali
Goljanian
ali.goljanian@hotmail.com
3
Taleghani Hospital, Tehran, Iran.
LEAD_AUTHOR
Nadereh
Alani
daneshyariran@yahoo.com
4
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
1.Ahlfors CE, Parker AE. (2008)Unbound bilirubin concentration is associated with abnormal automated auditory brainstem response for jaundiced newborns. Pediatrics.: 121(5):976-8.
1
2.Lasky RE, Church MW, Orlando MS, Morris BH, Parikh NA, Tyson JE, McDavid GE, Oh W, Stevenson DK, Van Meurs KP, Guillet R, Phelps DL.(2012)The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants. Pediatr Res. 71(1):77-84.
2
3.Nakamura H, Takada S, Shimabuku R, Matsuo M, Matsuo T, Negishi H.(1985) Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia. Pediatrics. 75(4):703-8.
3
4.Gupta AK, Mann SB. (1998)Is auditory brainstem response a bilirubin neurotoxicity marker? Am J Otolaryngol. 19(4):232-6.
4
5.Coenraad S, Goedegebure A, van Goudoever JB, Hoeve LJ. (2011)Risk factors for auditory neuropathy spectrum disorder in NICU infants compared to normal-hearing NICU controls. Laryngoscope. 121(4):852-5.
5
6.Amin SB, Ahlfors C, Orlando MS, Dalzell LE, Merle KS, Guillet R (2001).Bilirubin and serial auditory brainstem responses in premature infants. Pediatrics. 107(4):664-70.
6
7.Yilmaz Y, Degirmenci S, Akdas F, Kulekci S, Ciprut A, Yuksel S(2001)Prognostic value of auditory brainstem response for neurologic outcome in patients with neonatal indirect hyperbilirubinemia. J Child Neurol. 16(10):772–5.
7
8.Oğün B, Serbetçioğlu B, Duman N, Ozkan H, Kirkim G.(2003)Long-term outcome of neonatal hyperbilirubinaemia: subjective and objective audiological measures. Clin Otolaryngol Allied Sci. 28(6):507-13.
8
9.Amin SB.(2004)Clinical assessment of bilirubin-induced neurotoxicity in premature infants. Semin Perinatol. 28(5):340-7.
9
10.Shapiro SM, Popelka GR. (2011)Auditory impairment in infants at risk for bilirubin-induced neurologic dysfunction. Semin Perinatol. 35(3):162-70.
10
11.Rhee CK, Park HM, Jang YJ. (1999)Audiologic evaluation of neonates with severe hyperbilirubinemia using transiently evoked otoacoustic emissions and auditory brainstem responses. Laryngoscope. 109(12):2005-8.
11
12.Boo NY, Rohani AJ, Asma A. (2008)Detection of sensorineural hearing loss using automated auditory brainstem-evoked response and transient-evoked otoacoustic emission in term neonates with severe hyperbilirubinemia. Singapore Med J. 49(3):209-14.
12
13.Vlastarakos PV, Nikolopoulos TP, Tavoulari E, Papacharalambous G, Korres S. (2008)Auditory neuropathy: endocochlear lesion or temporal processing impairment? Implications for diagnosis and management. Int J Pediatr Otorhinolaryngol. 72(8):1135-50.
13
14.Ahlfors CE, Amin SB, Parker AE.(2009) Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population. J Perinatol.29(4):305–9.
14
15.Funato M, Tamai H, Shimada S, Nakamura H. (1994)Vigintiphobia, unbound bilirubin, and auditory brainstem responses. Pediatrics. 93(1):50-3
15
16.Baradaranfar MH, Atighechi S, Dadgarnia MH, Jafari R, Karimi G, Mollasadeghi A, Eslami Z, Baradarnfar A. (2011)Hearing status in neonatal hyperbilirubinemia by auditory brain stem evoked response and transient evoked otoacoustic emission. Acta Med Iran. 49(2):109-12.
16
17.Akman I, Ozek E, Kulekci S, Turkdogan D, Cebeci D, Akdas F. (2004)Auditory neuropathy in hyperbilirubinemia: is there a correlation between serum bilirubin, neuron-specific enolase levels and auditory neuropathy? Int J Audiol. 43(9):516–22
17
18.Gupta AK, Raj H, Anand NK(1990)Auditory brainstem responses (ABR) in neonates with hyperbilirubinemia. Indian J Pediatr. 57(5):705-11.
18
19.Rhee CK, Park HM, Jang YJ. (1999)Audiologic evaluation of neonates with severe hyperbilirubinemia using transiently evoked otoacoustic emissions and auditory brainstem responses. Laryngoscope. 109(12):2005-8.
19
20.Lee YK, Daito Y, Katayama Y, Minami H, Negishi H. (2009)The significance of measurement of serum unbound bilirubin concentrations in high-risk infants. Pediatr Int. 51(6):795-9.
20
ORIGINAL_ARTICLE
Effects of a Period of Selected Activity on Lung Capacities in Children 5-10 Years with Asthma Caused by Exercise
Background: Aasthma due to causing disruption in the work of breathing and obstruction of the pulmonary tract creates the physical restrictions in the social, emotional and psychological, aspects and performing daily life activities, hence the present study is conducted to determine the impact of a period of selected activity on some spirometry parameters of children from 5 to 10 years old suffering from asthma caused by exercise.Materials and Methods: In this half experimental respiratory research, respiratory indexes of 11 children including 5 boys under the age of 10 years old suffering from asthma caused by exercise were measured before and after eight weeks of selected exercises and pranayama by spirometry were measured.Results: The results showed that the selected exercise routine improves on the status of activities and being short of breath (Z=0/003). Also the average of spirometry indexes prior to a ten minutes exercise, before and after the intervention, compared with the average of spirometry indexes after a ten minute exercise, before and after intervention in the parameters: (fev1) the volume of the expiratory force in the first second, and (PEF) the maximum expiratory flow, the results are statistically significant (p 0.05).Conclusions: The present study shows the impact of the selected exercises in improving mobility status and being short of breath and reducing asthma symptoms caused by exercise (EIA) as well as strengthening the respiratory muscles significantly.
https://ijp.mums.ac.ir/article_3085_0d0ace76201af8f9bacb70f38c7a75bd.pdf
2014-09-01
11
17
10.22038/ijp.2014.3085
Asthma
Exercise
Pulmonary capacity
Pranayama
Spirometry
Gholamreza
Sharifi
1
Assistant Professor of Sports Science, Islamic Azad University, Khorasgan Branch, Isfahan, Iran.
AUTHOR
Alireza
Babai Mazreno
alireza.babaei.m@gmail.com
2
Master of Sports Physiology, Islamic Azad University, Science and Research Branch, young and Elite Researchers Club, Yazd, Iran.
LEAD_AUTHOR
Ibrahim
Salmani
3
Department of Health in Disasters, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Najme
Abyar
4
Department of Exercise Management, Education District Yazd, Yazd, Iran.
AUTHOR
1.Jonathan M. F, Paul M. L, Soo B, Teal S. H, Mahmood I. S. Health Care Use and Quality of Life Among Patients with Asthma and Panic Disorder. J Asthma. Apr 2005; 42(3): 179–184.
1
2.Iranpur A. "The prevalence of asthma in children aged 12 to 14 years 78 to 1,377 schools in the city." Namkh end for getting doctorate Professional University School of Medicine. 1378:29
2
3.Baradun J. Value and costs of pulmonary rehabilitation. Schweiz rundsch med prac. 1997 Dec 10;86(50):1979-83.
3
4.Ries et al. The importance of exercise in pulmonary Regablitation. Clin-chest-med. 1997;15(2):327-37
4
5.May Donald F.”Rehabilitation and continuity of care in pulmonary disease”. , 1994: 85.
5
6.Farias CC1, Resqueti V2, Dias FA1, Borghi-Silva A3, Arena R4, Fregonezi GA1. Costs and benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease: a randomized controlled trial. 2014 Mar-Apr;18(2):165-73
6
7.Chandratilleke MG1, Carson KV, Picot J, Brinn MP, Esterman AJ, Smith BJ. Physical training for asthma. Cochrane Database Syst Rev. 2013;9:CD001116.
7
8.Varray AL, Mercier JG, Terral CM, Prefaut CG. Individualized aerobic and high intensity training for asthmatic children in an exercise readaptation program. Is training always helpful for better adaptation to exercise?. Chest. 1991 Mar;99(3):579-86.
8
9.Paul T. Determinants of physical Fitness in Children With Asthma. Pianos and heather S. Davis. Pediatrics. 2004 Mar;113(3 Pt 1):e225-9
9
10.Alfaro V, Torras R, Prats MT, Palacios L, Ibáñez J. Improvement in exercise tolerance and spirometric values in stable chronic obstructive pulmonary disease patient after individualized outpatient rehabilitation program . J Sports Med Phys Fitness. 1996 Sep;36(3):195-203.
10
11.Carlsen KH, Carlsen KC. Exercise-induced asthma.PaediatrRespir Rev. Paediatr Respir Rev. 2002 Jun;3(2):154-60.
11
12.Yeke falah. L. (1380). Care of their health and quality of life in patients with asthma, Journal of Nursing, No. 17, pp. 20 to 29.
12
13.Engström I, Fällström K, Karlberg E, Sten G, Bjure J. Physiological and respiratory physiological effects of physical exercise program for boys with severe Asthma. Acta Paediatr Scand. 1991 Nov;80(11):1058-65. Actapadiatr scandal. 80 pp: 1058,1065.
13
14.Makwana K, Khirwadkar N, Gupta HC. The effect of short term yoga practice on ventilator function tests . Indian J Physiol Pharmacol. 1988 Jul-Sep;32(3):202-8.
14
15.Hallstrand TS, Bates PW, Schoene RB. Aerobic conditioning in mild asthma decrease hyperpnea of exercise and ventilator capacity . Chest. 2000 Nov;118(5):1460-9.
15
16.Emtner M, Finne M, Stålenheim G. a-3year follow up of asthmatic patients participating in a 10 week rehabilitation program with emphasis on physical training. Arch Phys Med Rehabil. 1998 May;79(5):539-44.
16
17.Singh v. (1987) ;”Effect of respiratory exercises on asthma. The Pink City long exerciser. J Asthma. 1987;24(6):355-9.
17
18.Cox NJ, Hendricks JC, Binkhorst RA, van Herwaarden CL.”A pulmonary rehabilitation program for patients with asthma and mild chronic obstructive pulmonary disease (COPD)”. Lung. 1993;171(4):235-44.
18
19.Fitch KD, Blitvich JD, Morton AR. ”the effect of running training on exercise-induced asthma”. Ann Allergy Aug 1986; 57(2):90-4
19
ORIGINAL_ARTICLE
Evaluation of Clinical and Laboratory Data in Patients with Recurrent Infections and Suspected Immunodeficiency
Background: Frequent infections is among the most frequent clinical dilemmas for primary care physicians. Immunodeficiency disorders are a heterogeneous group of illnesses that predispose patients to the recurrent infections, autoimmunity and malignancies. The aim of this study was to evaluate the clinical and laboratory data collected for the final diagnosis of patients referred with recurrent infections and suspected immunodeficiency to a local immunodeficiency clinic. Methods: This epidemiological study was carried out between April 2010 and September 2012 at the Immunodeficiency Clinic of Mashhad. All patients with clinical manifestations of immunodeficiency who were referred to our clinic during this period of time were included in this study. 41 patients aged from 10 months to 51 years, were evaluated. Results: Forty one patients, aged between 10 months and 51 years were evaluated. Eleven patients had a primary immunodeficiency, four cases had a secondary immunodeficiency, in three patients an underlying structural disease were found, eight patients were predisposed to recurrent infections as a result of allergies and finally, fifteen cases were found to be normal individuals. Discussion: Most patients with recurrent infection have a normal immune system. Allergic disorders are the most common predisposing factor to recurrent infection. However, as immunodeficiency disorders are potentially serious, early diagnosis can improve the quality of life and outcome and prevent severe sequels in future.
https://ijp.mums.ac.ir/article_2996_d540b02f3f3f2a3bc2d0220ac6eb0473.pdf
2014-09-01
19
24
10.22038/ijp.2014.2996
Primary immunodeficiency
Recurrent infection
Allergy
Secondary immunodeficiency
Hamid
Ahanchian
1
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farahzad
Jabbari Azad
2
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Catherine
Gangel
3
The Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, Australia
AUTHOR
Fatemeh
Behmanesh
4
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Carmen
M Jones
5
The Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, Australia
AUTHOR
Reza
Purreza
6
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Elham
Ansari
7
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Nasrin
Moazzen
moazzenn@mums.ac.ir
8
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Reza
Farid
9
Allergy Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
1. Kliegman RM, Behrman RE, Jenson HB, Stanton BF. Textbook of Pediatrics. 19th ed.: Philadelphia: Saunders; 2011.
1
2. Ballow M. Approach to the patient with recurrent infections. Clinical Reviews in Allergy and Immunology. 2008;34(2):129-40.
2
3. Gray PE, Namasivayam M, Ziegler JB. Recurrent infection in children: when and how to investigate for primary immunodeficiency? J Paediatr Child Health. 2012 Mar;48(3):202-9.
3
4. Stiehm ER, Ochs HD, Winkelstein JA. Immunodeficiency disorders: general considerations. In: Stiehm ER, Ochs HD, Winkelstein JA, editors. Immunologic disorders in infants and children. 5th ed: Philadelphia: Saunders; 2004. p. 289-355.
4
5. Buckley RH. Primary immunodeficiency or not? Making the correct diagnosis. Journal of allergy and clinical immunology. 2006;117(4):756-8.
5
6. Lee WI, Kuo ML, Huang JL, Lin SJ, Wu CJ. Distribution and clinical aspects of primary immunodeficiencies in a Taiwan pediatric tertiary hospital during a 20-year period. J Clin Immunol. 2005 Mar;25(2):162-73.
6
7. Nourijelyani K, Aghamohammadi A, Salehi Sadaghiani M, Behniafard N, Abolhassani H, Pourjabar S, et al. Physicians awareness on primary immunodeficiency disorders in Iran. Iran J Allergy Asthma Immunol. 2012 Mar;11(1):57-64.
7
8. Champi C. Primary immunodeficiency disorders in children: prompt diagnosis can lead to lifesaving treatment. J Pediatr Health Care. 2002 Jan-Feb;16(1):16-21.
8
9. Adkinson NF, Bocher B, Busse WW, Holgate ST, Lemanske RF, Simon FER. Middleton Allergy Priciples and Practice. 7th ed.: Philadelphia:Mosby; 2009.
9
10. Rich RR, Fleisher TA, Shearer TW, Schroeder HW. Clinical Immunology principles and practice. 3th ed.: NewYork.Elsevier; 2008.
10
11. Stiehm ER, Ochs HD, Winkelstein JA. Immunodeficiency disorders: general considerations. In: Stiehm ER, Ochs HD, Winkelstein JA, editors. Immunologic disorders in infants and children. 5th ed: Philadelphia: Saunders; 2004. p. 289–355.
11
12. McCusker C, Warrington R. Primary immunodeficiency. Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology. 2011;7(Suppl 1):S11.
12
13. Rezaei N, Aghamohammadi A, Moin M, Pourpak Z, Movahedi M, Gharagozlou M, et al. Frequency and clinical manifestations of patients with primary immunodeficiency disorders in Iran: update from the Iranian Primary Immunodeficiency Registry. J Clin Immunol. 2006 Nov;26(6):519-32.
13
14. Jabbari Azad F, Ardalan M, Hoseinpoor Rafati A, Sotoudeh S, Pourpak Z. Osteomyelitis in leukocyte adhesion deficiency type 1 syndrome. J Infect Dev Ctries. 2010 Mar;4(3):175-8.
14
15. Chinen J, Shearer WT. Secondary immunodeficiencies, including HIV infection. The Journal of allergy and clinical immunology. 2010;125(2 Suppl 2):S195.
15
16. Lim DL, Thong BY, Ho SY, Shek LP, Lou J, Leong KP, et al. Primary immunodeficiency diseases in Singapore--the last 11 years. Singapore Med J. 2003 Nov;44(11):579-86.
16
17. Notarangelo LD, Fischer A, Geha RS, Casanova JL, Chapel H, Conley ME, et al. Primary immunodeficiencies: 2009 update. J Allergy Clin Immunol. 2009 Dec;124(6):1161-78.
17
ORIGINAL_ARTICLE
The Clinical Manifestations, Treatment Efficacy and Adverse Drug Reactions in 62 Iranian Child with Wilson Disease
Introduction: The Wilson disease is an autosomal recessive disease in which the liver, central nervous system, eyes, blood and other parts of the body involved. Timely diagnosis and appropriate treatment of the disease requires awareness of the clinical presentations of this disease in children.Methods: This case series study included 62 patients with Wilson disease who admitted to children's Medical Center in the years 2012-2003.Results: 56% of patients were male. The average age of diagnosis was 9.73 years old (5-17 years) and this was higher in patients with early neurologic symptoms (P = 0.85.( 64.5% of the patients had the hepatic symptoms at the time of diagnosis and the most common type of hepatic involvement was cirrhosis (39.3%) and hepatitis (17.5%) respectively. 17.7% of the patients also had early neurological symptoms. A positive family history for the Wilson Disease were found in 27.4% of patients. 74.2% of patients had KF ring and the frequency of these symptom was higher in patients with early neurological involvement. 83.9% of patients were treated successfully with D-penicillamine and In 30% of patients, adverse drug reactions were seen.Conclusion: Children with unknown liver disease should be evaluated for Wilson disease and the first-degree relatives of patients should be screened. . D-penicillamine have important side effects, but due to the low cost and the availability is an appropriate drug to treat the Wilson disease..Key words: Wilson Disease, Hepatic Involvement, Neurologic Involvement , KF ring ,D-Penicillamine.
https://ijp.mums.ac.ir/article_3088_e4ae4fedc75fe162cfc0d2e1e4420548.pdf
2014-09-01
25
29
10.22038/ijp.2014.3088
D-penicillamine
Hepatic Involvement
KF ring
Neurologic Involvement
Wilson disease
Mehri
Najafi
najafisa@sina.tums.ac.ir
1
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Hosein
Alimadadi
hoseinalimadadi@yahoo.com
2
Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Leila
Arastoo
arastoo.leila@gmail.com
3
Tehran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Farzaneh
Motamed
dr_f_motamed@yahoo.com
4
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Ahmad
Khodadad
khodadadmd@yahoo.com
5
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Gholamhosein
Fallahi
dr.ghfallahi@yahoo.com
6
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Fatemeh
Farahmand
ffarahmand@sina.tums.ac.ir
7
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Rana
Doroudian
rana1596@yahoo.com
8
Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
1- Ala A, Walker AP. Ashkan K. Dooley Js. “Wilson diseases”. Lancet 369(9559): 397-408.doi: 10.1016/so 140-6736(07)60196.
1
2- Santos RG, Alissa F, Reyes J, Teot L, Ameen N.” Fulminant hepatic failure : Wilson’s disease or autoimmune hepatitis Implications for transplantation. Pediatr Transplant 2005:9:112-16.
2
3- Wilson ML, Portman B, Wilson R. “ Wilson disease and hepatocellular carcinoma : possible protective role of copper “ Gut 1983; 24: 767-71.
3
4- Sinha S, Taly AB, Ravishankar S, et al. “Wilson’s disease: cranial MRI observation and clinical and correlation “ Neuroradiology 2006:48: 613-21.
4
5- Taly AB, Meenakshi- Sundaram S, Sinha S, et al: Wilson diseases. Description of 282 patients evaluated over 3 decades. Medicine 2007; 82:112-121.
5
6- Schilsky ML: Wilson Disease : new insights into pathogenesis, diagnosis, and future therapy. Curr Gastroenterol Rep 2005;7:26-31.
6
7- Roberts EA, Schilsky ML: “diagnosis and treatment of Wilson diseases “: an update Hepatology 2008; 47(6): 2089-2111.
7
8- Brewer Gj, Askari FK (2005). “Wilson’s disease: clinical management and therapy “journal of hepatology 42.
8
9- Walsehe JM (march 1982) “ treatment of Wilson disease with Trientinee ( triethylene tetramine dihydrochloride” Lancet 1 (8273): 643.7
9
10- Walsehe JM (January 1956)” Wilson disease ; new oral therapy” lancet 267 (6906): 25-6.PMID13279157
10
11- Medici V, Mirante VG, Fassati LR, et al. Monotematica AISF 2000 OLT Study group “liver transplantation for Wilson disease : the burden of neurological and psychiatric disorders.” Liver transportation 2005 11:1056-63.
11
12- Bem RS.Muzzilo DA.Degutimm…Wilson Disease in southern Brazil:A 40Year Follow up Clinic (Saopaulo ) 2011; 66(3)411-16
12
13- Tatsumity, Hattori A. Hayash.H “ current safe of WD patient in central Japan” 2010; 49(9): 809-15 Epud. Apr 30.
13
14- Asadi Pooya , A. Eslami , N. Haghighat” Wilson disease in southern Iran” 2005 jun. 16(2):71-4
14
15- Walter oder_Georgegrim. “ neurological and neuropsychiatric spectrum of Wilson disease, a prospective study of 45 case” journal of neurology. Vol 238-(2005)-281-287DOI:10.1007/Bf-003/97
15
16- Merleu.Scherfer, ferenci P.Stremel W. “ Clinical presentation diagnosis and long term outcome of WD” 2007 Jan. 56(1):115-20Epub
16
ORIGINAL_ARTICLE
"Comparison of Parenting Related Stress and Depression Symptoms in Mothers of Children with and without Autism Spectrum Disorders(ASD)
Abstract Backgrounds: When a child has a developmental disability, the parenthood stress can be onerous. Research on the parenting stress has addressed the parenting stress differences between children families with and without disabilities. The purpose of the current research was to examine the comparison of parenting related stress and depression symptoms in mothers of children recently diagnosed with and without autism spectrum disorders.Materials and Methods: In this semi-experimental study that was performed using both experiment and control groups, 15 mothers of children was recruited (biological mothers of children with autism spectrum disorders aged 6 years who’s diagnosed were made less than 5 months prior to study) and was compared with 15 mothers of children without autism spectrum disorders were selected with using of available sampling method and randomly were replaced into two experimental and control groups. Parents completed a packet of questionnaire measuring demographics, parenting stress and depression. Data were analyzed using of descriptive statistics, t-test method. Results: Results of t tests showed significant differences between the two groups for two variables (p<0.001). Mothers of children with an autism spectrum disorder generally report significantly higher levels of stress and depression than mothers of children without autism spectrum disorder. Conclusion: According to the findings of the present study, the investigation of parenting related stress and depression in mothers of children with autism spectrum disorder can provide valuable implications for clinicians to target at the predictors when providing assessment and intervention for children with ASD to improve their health parent.
https://ijp.mums.ac.ir/article_3133_226514423869c87f6ca0e3ac7d2da95b.pdf
2014-09-01
31
37
10.22038/ijp.2014.3133
Autism
Depression
Parenting related stress
Fariba
Kiani
fariba.kiani64@yahoo.com
1
1. PhD in Psychology, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
AUTHOR
Mohamad Reza
Khodabakhsh
khodabakhsh@ut.ac.ir
2
Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran
LEAD_AUTHOR
Hamed
Khastwo Hashjin
khodabakhsh@aut.ac.ir
3
3. MSc Student in Education Management, Faculty of Psychology and Education Science, Allameh Tabataba’i University, Tehran, Iran
AUTHOR
Crnic KA, Low C, Bornstein M. Everyday stresses and parenting. Handbook of parenting: Vol 5 Practical issues in parenting. 2002: 243-67.
1
American Psychiatric Association. Diagnostic and statistical manual of mental disorders (5th ed.). Washington DC: APA; 2013.
2
Zaroff CM, Uhm SY. Prevalence of autism spectrum disorders and influence of country of measurement and ethnicity. Soc Psychiatr Psychiatr Epidemiol 2012; 47(3):395–398.
3
Kasari C, Sigman M. Linking parental perceptions to interactions in young children with autism. J Autism Dev Disord 1997; 27:39–57
4
Bailey D, Simeonsson R, Winton P, Le Couteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M. Family focused intervention: a functional model for planning, implementing, and evaluating individualized family services in early intervention. J Div Early Child 1986; 10(1):156–171.
5
Lecavalier L, Leone S, Wiltz J. The impact of behavior problems on caregiver stress in young people with autism spectrum disorders. J Intell Disabil Res 2006; 50:172–183
6
Abidin RA. Introduction to the special issue: the stresses of parenting. Journal of Clinical Child Psychology 1990; 19(4): 289-301.
7
Konstantareas MM, Papageorgiou V. Effects of temperament, symptom severity and level of functioning on maternal stress in Greek children and youth with ASD. Autism 2006; 10(6): 593-607.
8
Bromley J, Hare DJ, Davison K, Emerson E. Mothers supporting children with autistic spectrum disorders. Autism 2004; 8 (4): 409-423.
9
Seligman M, Darling RB. Ordinary families, special children. (3rd ed.). New York: The Guilford Press; 2007.
10
Weiss JM. Hardiness and social support as predictors of stress in mother of typical children, children with autism, and children with mental retardation. Autism 2002; 6(1): 115-130.
11
Duarte CS, Bordin IA, Yazigi L, Mooney J. Factors associated with stress in mothers of children with autism. Autism 2005; 9(4): 416-427
12
Phetrasuwan S, Miles MS. Parenting stress in mothers of children with autism spectrum disorders. Journal for Specialists in Pediatric Nursing 2009; 14(3): 157-165.
13
Smith LE, Seltzer MM, Tager-Flusberg H, et al. A comparative analysis of well-being and coping among mothers of toddlers and mothers of adolescents with ASD. Journal of Autism and Developmental Disorders 2008; 38: 876–889.
14
Lounds J, Seltzer MM, Greenberg JS, et al. Transition and change in adolescents and young adults with autism: longitudinal effects on maternal well-being. American Journal on Mental Retardation 2007; 112: 401–417.
15
Tahmassian K, Anari MA and Fathabadi M. The influencing factors of parenting stress in Iranian mothers. International Conference on Social Science and Humanity 2011; 5: 190–192.
16
Pisula E, Kossakowska Z. Sense of coherence and coping with stress among mothers and fathers of children with autism. Journal of Autism and Developmental Disorders 2010; 40: 1485–1494.
17
Abidin RA. In: Parenting Stress Index: Short Form (PSI-SF). 3rd ed. Odessa, FL: Psychological Assessment Resources, Inc; 1995.
18
Taylor JL, Warren ZE. Maternal depressive symptoms following autism spectrum diagnosis. Journal of Autism and Developmental Disorders 2011; 42(7):1411–1418.
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Estes A, Olson E, Sullivan K, Greenson J, Winter J, Dawson G, et al. Parenting-related stress and psychological distress in mothers of toddlers with autism spectrum disorders. Brain & Development 2013;, 35: 133–138.
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McStay RL, Dissanayake C, Scheeren A, Koot HM, Begeer S. Parenting stress and autism: The role of age, autism severity, quality of life and problem behavior of children and adolescents with autism. Autism. 2013:1362361313485163.
21
Carter AS, Martı´nez-Pedraza FDL, Gray SAO. Stability and individual change in depressive symptoms among mothers raising young children with ASD: Maternal and child correlates. Journal of Clinical Psychology 2009; 65: 1270–1280.
22
Herring S, Gray K, Taffe J, Tonge B, Sweeney D, Einfeld S. Behavior and emotional problems in toddlers with pervasive developmental disorders and developmental delay: Associations with parental mental health and family functioning. Journal of Intellectual Disability Research 2006; 50: 874–882.
23
World Health Organization. Mental health: Depression. Retrieved from http://www.who.int/topics/depression/en/; 2012.
24
Kruijshaar ME, Barendregt J, Vos T, De Graaf R, Spijker J, Andrews G. Lifetime prevalence estimates of major depression: An indirect estimation method and a quantification of recall bias. European Journal of Epidemiology 2005; 20: 103-111.
25
Montes G, Halterman JS. Psychological functioning and coping among mothers of children with autism: A population-based study. Pediatrics 2007; 119: 1040–1046.
26
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27
Olsson MB, Hwang CP. Depression in mothers and fathers of children with intellectual disability. Journal of Intellectual and Disability Research 2001; 45: 535–543.
28
Beck AT, Steer RA and Brown GK. Manual for the Beck Depression Inventory-II. San Antonio, TX: Psychological Corporation; 1996.
29
Ward LC. Comparison of factor structure models for the Beck Depression Inventory-II. Psychological Assessment 2006; 18: 81–88.
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Vanheule S, Desmet M, Groenvynck H, Rosseel Y and Fontaine J. The factor structure of the Beck Depression Inventory-II: an evaluation. Assessment 2008; 15(2): 177–187.
31
Hassall R, Rose J, McDonald J. Parenting stress in mothers of children with an intellectual disability: The effects of parental cognitions in relation to child characteristics and family support. Journal of Intellectual Disability Research 2005; 49: 405–418.
32
Tomanik S, Harris GE, Hawkins J. The relationship between behaviours exhibited by children with autism and maternal stress. Journal of Intellectual and Developmental Disability 2004; 29: 16–26.
33
Estes A, Munson J, Dawson G, Koehler E, Zhou X, Abbott R. Parenting stress and psychological functioning among mothers of preschool children with autism and developmental delay. Autism 2009; 13: 375–387.
34
Rao PA, Beidel DC. The impact of children with high-functioning autism on parental stress, sibling adjustment and family functioning. Behavior Modification 2009; 33: 437–451.
35
Davis NO, Carter AS. Parenting stress in mothers and fathers of toddlers with autism spectrum disorders: Associations with child characteristics. Journal of Autism and Developmental Research 2008; 38: 1278–1291.
36
Dyson LL. Response to the presence of a child with disabilities: Parental stress and family functioning over time. American Journal of Mental Retardation 1993; 98: 207–218.
37
Beer M, Ward L, Moar K. The relationship between mindful parenting and distress in parents of children with an autism spectrum disorder. Mindfulness 2013; 1: 1–11.
38
ORIGINAL_ARTICLE
Psychological Well-being and Parenting Styles as Predictors of Mental Health among Students: Implication for Health Promotion
Introduction: The lack of mental health interferes with one's individual achievement and ability for undertaking the responsibilities of everyday life. Researches show that psychological well-being and parenting styles have an important role in ones' increasing general health. The current study examined the relationship between psychological well-being and parenting styles with students' mental health. Methods: This study was carried out on 278 students (124 boys and 154 girls) of Boukan's high schools. The participants were asked to complete psychological well-being inventory and mental health parenting style questionnaire. Data was analyzed using of Pearson correlation coefficient and regression analysis. Results: The results showed that psychological well-being and authoritative parenting styles were significantly related with mental health; also, Permissive parenting styles has significant positive relationship with mental health. The regression analysis indicated that mental health is predictable by psychological well-being and parenting styles. Conclusion: The knowledge of parenting styles and psychological well-being and their relationships with general well-being can provide the significant implications on the provision of students' health. Parenting styles and psychological well-being, as significant variables in general well-being, needs more clinical research.
https://ijp.mums.ac.ir/article_3003_d8740eb5e76a6cf9205477a39e30a931.pdf
2014-09-01
39
46
10.22038/ijp.2014.3003
Mental health
Psychological well-being
Parenting Styles
Students
Mohammad reza
khodabakhsh
khodabakhsh@ut.ac.ir
1
PhD in Psychology, Young Researchers and Elite Club, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
LEAD_AUTHOR
Fariba
kiani
fariba.kiani64@yahoo.com
2
PhD in Psychology, Young Researchers and Elite Club, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.
AUTHOR
Soliman
Ahmedbookani
mr_khodabakhsh@yahoo.com
3
M.A in Rehabilitation Counseling, Allameh Tabataba’i University, Tehran, Iran.
AUTHOR
Nesse RM. Evolutionary psychology and mental health. In David buss (ed). Handbook of evolutionary psychology. Hoboken, NJ: John Wiley and sons, 2005; 203-937.
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Fouhy CSM. Spiritual Well-Being and Physical Activity: Their Influence on Self-Esteem and Life Satisfaction. [PhD Thesis]. Capella University; 2007.
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Diener E, Sapyta JJ, Suh E. Subjective well-being is essential to well-being. Psychol INQ,, 1998; 9: 7-33.
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Ryff CD, Singer B. Psychological well – being: Meaning measurement and implication for psychotherapy. Psychother Psychosom, 1996;23: 14 - 65 .
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Roini, C., Ottolini, F., Raffanelli., C,Tossani, E., Ryff, CD., & Fave, A.G. )2003 ( . The Relationship of psychological well–being distress and personality. Psychother Psychosom, 2003;27: 268 -375.
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Kazdin AE, Marciano, PL, Whitley M k. The therapeutic alliance in cognitive- behavioral treatment of children referred for oppositional aggressive and antisocial behavior. J Consullt Clin Psych, 2005; 73(4): 726-730.
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Kazdin AE, & Whitley MK. Comorbidity, case complexity, and effects of evidence-based treatment for children referred for disruptive behavior. J Consult Clin Psych, 2006; 74(3): 455-467.
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Kazdin AE, & Whitley MK. Pretreatment social relations, therapeutic alliance, and improvements in parenting practices in parent management training. J Consult Clin Psych, 2006; 74(2): 346-355.
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Dooley M, Stewart J. Family Income, parenting styles and child Behavioral. Emotional outcomes. Heal Thecon, 2006; 16:145-162.
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Roeser RW, and Eccles JS. Schooling and mental health. Handbook of developmental psychopathology, Springer, 2000; 135-156.
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Marin CE. Parental Involvement and Group Cognitive Behavioral Treatment for Anxiety Disorders in Children and Adolescents: Treatment Specificity and Mediation Effects;2010: p256.
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Boon HJ. Low and high achieving austral lain secondary school students: Their parenting, motivations and academic achievement. Am Psychol, 2007; 42(3): 212-225
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Wilder E. & watt TT. Risky parental behavior and adolescent sexual. Activity at first coitus. Milbank Q, 2002; 80: 481-524.
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Argys LM. Birth order and risky adolescent behavior. Econin Q, 2005; 44: 215-233.
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Aizer A. Home Alone: supervision after school and child behavior. J Public Econ, 2004; 88: 1835-1848.
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Council C L. Child life services. Pedia Trics, 2006; 118(4): 1757-1763.
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McCullough ME. Bono G. Religion and forgiveness. Handbook of the psychology of religion and spirituality, 2005; 394-411.
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Leong P. Religion, flesh and blood: Re-creating religious culture in the context of HIV/AIDS. Soc Reli, 2006; 67(3): 295-311
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Buri J R. Parental authority questionnaire. J Pers Assess, 1991; 57 (1): 110- 119.
35
Shokri O, Kadivar P and Daneshpour Z . Sex differences in psychological well-being: the role of personality characteristics. The J Pers Soc Psychol , 2007; 13(3): 280-289.
36
Arrindell A W, Heesink J, & Fei J. The satisfaction with life scale (SWLs): Appraisal with 1700 healthy young adults in the Netherlands. Pers Indiv Differ, 1999; 26: 815- 826 .
37
Bayani . A, Kouchaki AM. Reliability and Validity of Ryff’s Psychological well-being Scales. Iranian Journal Psychiatr Clin Psychol, 2008; 14:146-51.
38
Roini C, Ottolini F, Raffanelli C,Tossani E, Ryff CD, & Fave AG. The Relationship of psychological well–being distress and personality, Psychother Psychosom , 2003; 72: 268-375 .
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41
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42
ORIGINAL_ARTICLE
Dynamic Assessment( DA) and Evaluation of Problem-solving Skills in Childeren
Introduction: The term dynamic assessment (DA) refers to an assessment, by an active teaching process, of a child's perception, learning, thinking, and problem solving. The process is aimed at modifying an individual's cognitive functioning and observing subsequent changes in learning and problem-solving patterns within the testing situation. DA has been advocated as an alternative and/or supplemental approach to traditional standardized testing with children who are culturally and linguistically diverse (CLD). Methods: This study was a causal-comparative that including 58 children of 5 kindergartens of Mashhad, with 6 to 6.5-year-old, with available sampling. Kindergartens were selected of areas (1,2,4,5,6) of Mashhad-Iran. Variable of intelligence in children, was controlled by the Raven’s IQ test. Results: Eight children were perceived process at the level of symbolic, eighteen children in the visual-image (visual) and thirty-two children were perceived process at the level of visual-motor (functional representation). Results showed children were perceived process at the level of symbolic, only 50% of them were used these method in practice. These results for children in the visual-image was 66.6% and for children were perceived process at the level of visual-motor was 68.7%. Conclusion: Dynamic assessment is a method of education and according to methods of teacher (symbolic, visual, functional representation), children also, often engage in the same level of performance and problem solving. Keywords: Children, Dynamic assessment, Problem-solving, ZPD.
https://ijp.mums.ac.ir/article_3150_39903d3c12c741c38a8faab2cfd0316e.pdf
2014-09-01
47
54
10.22038/ijp.2014.3150
Children
Dynamic assessment
Problem-Solving
ZPD
Hamid
Rahbardar
1
Ph.D of Assessment and Psychometric, Assistant Professor of Teachers University, Mashhad, Iran.
AUTHOR
Maryam
Ajilian Abbasi
2
Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Ali
Talaei
talaeia@mums.ac.ir
3
Associate Professor, Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
1. Grigorenko E. L. Dynamic assessment and response to intervention: Two sides of one coin. Journal of Learning Disabilities 2009, 42(2), 111–32.
1
2.Lidz CS. Practitioner's guide to dynamic assessment. New York, NY: Guilford; 1991.
2
3.Lidz CS, Peña ED. Response to intervention and dynamic assessment; do we just appear to be speaking the same language. Seminars in Speech and Language 2009; 2: 121–133.
3
4.Banks S R, Neisworth JT. Dynamic assessment in early intervention applications for serving American Indian/Alaska Native families. Journal of American Indian Education 1995; 34(2). Retrieved from http://jaie.asu.edu/v34/V34S2dyn.htm.
4
5.Feuerstein R, Rand Y, Hoffman MB. The Dynamic Assessment of Retarded Performers: The Learning Potential Assessment Device: Theory, Instruments, and Techniques. Baltimore: University Park Press, 1979.
5
6.Haywood H. Carl"Interactive Assessment." In Assessment of Individuals with Mental Retardation, ed. Ronald L. Taylor. San Diego, CA: Singular; 1997.
6
7.Haywood HC, Tzuriel D. Interactive Assessment. Berlin: Springer-Verlag.
7
8.Lidz CS, Dynamic Assessment. New York: Guilford;1992.
8
9.Tzuriel D. "Parent-Child Mediated Learning Transactions as Determinants of Cognitive Modifiability: Recent Research and Future Directions." Genetic, Social, and General Psychology Monographs 1999; 125:109 - 56.
9
10.Tzuriel D. Dynamic Assessment of Young Children. New York: Kluwer Academic/Plenum; 2001.
10
11.Tzuriel D, Haywood HC. "The Development of Interactive-Dynamic Approaches for Assessment of Learning Potential. In Interactive Assessment, ed. H. Carl Haywood and David Tzuriel. New York: Springer-Verlag; 1992.
11
12.Tzuriel D, Klein PS. "Analogical Thinking Modifiability in Disadvantaged, Regular, Special Education, and Mentally Retarded Children." Journal of Abnormal ChildPsychology 1985; 13:539 - 52.
12
13.Tzuriel D, Samuels MT. "Dynamic Assessment of Learning Potential: Inter-Rater Reliability of Deficient Cognitive Functions, Type of Mediation, and Non-Intellective Factors." Journal of Cognitive Education and Psychology 2000; 1:41 - 64.
13
14.VygotskyLS. Mind in Society. Cambridge, MA: Harvard University Press;1978.
14
15.Vygotsky, LS. Thought and Language. Cambridge, MA: MIT Press; 1962.
15
16.Wertsch JV. Cultural, Communication, and Cognition: Vygotskian Perspectives. Cambridge University Press; 1985.
16
17.Bruner JS. (1966). Toward a theory of instruction. Cambridge, MA: Belknap Press of Harvard University Press; 1966.
17
18.Bruner JS, Haste H. Making sense: The child's construction of the world. New York: Methuen; 1987.
18
19.Anderson RH, Pavan BN. Nongradedness: Helping it to happen. Lancaster, PA: Technomic Publishing; 1993.
19
ORIGINAL_ARTICLE
Psychogenic Vomiting: A Clinical Diagnosis Merits Special Attention in Pediatrics
A 2 years and 9 months old boy attended to a gastroenterology clinic of pediatric hospital for investigation of recurrent and intractable vomiting. He had post prandial, non-projectile, non-bilious emesis since past 2 years. Since the onset of illness, he was carried to many doctors and underwent extensive laboratory investigations. Because all of the science lab and imaging work up for etiology of emesis was normal and there wasn't any clinical response to medical treatment, psychological consultation with suspicion of psychogenic vomiting was done. After psychological consultation and treatment, including teaching the feeding techniques for mother, there was a dramatic recovery and the vomiting stopped. A diagnosis of psychogenic vomiting was made. He was discharged with the advice to attend regular supportive psychotherapy sessions.
https://ijp.mums.ac.ir/article_3014_abaa3a5fed685bc70f988ef8a4546434.pdf
2014-09-01
55
58
10.22038/ijp.2014.3014
Intractable
Pediatrics
Psychogenic
Psychotherapy
vomiting
Farzaneh
Motamed
dr_f_motamed@yahoo.com
1
Tehran University of Medical Sciences, Department of Pediatric Gastroenterology, Children's Medical Center
AUTHOR
Minoo
Dadkhah
minoodadkhah@yahoo.com
2
Department of pediatrics, Tehran University of Medical Sciences,Children Medical Center
LEAD_AUTHOR
pejman
Rohani
rohanipejman@hotmail.com
3
Tehran University of Medical Sciences, Department of Pediatric Gastroenterology, Children's Medical Center
AUTHOR
Rosenthal RH, Webb WL, Wruble LD. Diagnosis and management of persistent psychogenic vomiting. Psychosomatics 1980; 21.9 : 722-30.
1
Gonzalez-Heydrich J, Kerner JA, Steiner H. Testing the psychogenic vomiting diagnosis: four pediatric patients. American Journal of Diseases of Children 1991; 145(8): 913-16.
2
Hoyt CS, Stickler GB. A study of 44 children with the syndrome of recurrent (cyclic) vomiting. Pediatrics 1960; 25(5): 775-80.
3
. Pazulinec R, Sajwaj T. Psychological treatment approaches to psychogenic vomiting and rumination. Psychophysiology of the Gastrointestinal Tract. Springer US, 1983;43-63.
4
Laybourne PC , Miller HC. Pediatric hospitalization of psychiatric patients: Diagnostic and therapeutic implocations. American Journal of Orthopsychiatry 1962; 32.4: 596-603.
5
Holvoet JF. The etiology and management of rumination and psychogenic vomiting: a review. Monographs of the American Association on Mental Deficiency (1982) 5 (1981): 29-77.
6
Chow S, Goldman RD. Treating children’s cyclic vomiting. Can Fam Physician 2007; 53.3: 417-19.
7
Sokel B S, Devane SP, Bentovim A, Milla PJ. Self hypnotherapeutic treatment of habitual reflex vomiting. Arch Dis Child 1990; 65.6: 626-27.
8
O'Connor PA, Poznanski AK, Poznanski EO. Transient Superior Mesenteric Artery Syndrome and Psychogenic Vomiting A Case Study in Diagnosis and Management. Clin Pediatr 1974; 13.2: 166-69.
9
Rho JM. Cyclic vomiting syndrome. MedLink Neurology (2006).
10
ORIGINAL_ARTICLE
Asymptomatic Celiac Disease in Children with Trisomy 21 at 26 Months of Age or Less
We report three cases of asymptomatic celiac disease identified in children with Down syndrome after being screened at around twenty-four months of age. These cases raise the question as to what age is screening for celiac disease indicated in a child with Down syndrome and no symptoms.
https://ijp.mums.ac.ir/article_3082_ad158794123cf5749b4fda29447b3ff2.pdf
2014-09-01
59
62
10.22038/ijp.2014.3082
Down syndrome
Sprue
malabsorption
Nancy
J. Roizen
1
Professor of Pediatrics
Rainbow Babies and Children's Hospital
Case Western Reserve School of Medicine
Cleveland, Ohio USA
AUTHOR
Manoochehr
Karjoo
karjoom@upstate.edu
2
Professor of Pediatrics
SUNY Upstate Medical University
Syracuse, New York USA
LEAD_AUTHOR
Cohen WI. Health care guidelines for individuals withy Down syndrome: 1999 revision (Down syndrome preventive medical checklist). Down Syndr Quart 1999;4:1-21.
1
Celiac Disease Guideline Committee of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. JPGN 2005; 40:1-19.
2
Rostom A, Murray JA, Kagnoff MF. American Gastroenterological Association (AGA) Institute technical review on the diagnosis and management of celiac disease. Gastroenterology 2006;131:1981-2002.
3
Bull MJ and the Committee on Genetics. Clinical report-Health supervision of children with Down syndrome. Pediatrics 2011;128:393-406.
4
Shamaly H, Hartman C, Pollack S, et al. Transglutaminase antibodies are a useful serological marker for the diagnosis of celiac disease in patients with Down syndrome. J Pediatr Gastroenterology Nutrition 2007;44:583-6.
5
Carnicer J, Farre C, Varea V, et al. Prevalence of celiac disease in Down’s syndrome. Eur J Gastroenterol Hepatol 2001;13:263-267.
6
Bonamico M, Mariani P, Danese HM, et al. Prevalence and clinical picture of celiac disease in Italian Down syndrome patients: a multicenter study. J Pediatr Gastro Nutrit 2001;33:139-143.
7
Sciberras C, Vella C, Grech V. The prevalence of celiac disease in Down’s syndrome in Malta. Annals Tropical Medicine 2004;24:81-3.
8
Uibo O, Teesalu K, Metskula K, et al. Screening for celiac disease in Down syndrome patients in Estonia revealed cases of subtotal villous atrophy without typical for celiac disease HLA-DQ and tissue transglutaminase antibodies. World J Gastroenterology 2006;12:1430-4.
9
Swigoski NL, Kuhlenschmidt HL, Bull MJ, et al. Screening for celiac disease in asymptomatic children with Down syndrome: cost-effectiveness of preventing lymphoma. Pediatrics 2006; 118:594-602.
10
Burgin-Wolff A, Gaze H, Hadzieselimovic F, et al. Antigliadin and antiendomysium antibody determination for celiac disease. Arch Dis Child 1991; 66:941-947.
11
van Koppen EJ, Schweizer JJ, Csizmadia CGDS, et al. Long-term health and quality-of-life consequences of mass screening for childhood celiac disease: a 10-year follow-up study. Pediatrics 2009;123:e582-e588.
12
ORIGINAL_ARTICLE
Type 1 Tyrosinemia with Hypophosphatemic Rickets; a Case Report
Background: Tyrosinemia type 1 is an autosomal recessive metabolic disorder, which typically affects liver and kidneys. It is caused by a defect in fumarylacetoacetate hydrolase or fumarylacetoacetase (FAH) enzyme, the final enzyme in the tyrosine degradation pathway. The disease typically manifests as early onset type in early infancy with acute hepatic crisis with hepatomegaly and bleeding tendency. In 1992, a new drug orfadin (NTBC, Nitisinone) which is a potent inhibitor of 4 hydroxy phenyl pyrovate dioxygenase has revolutionized the treatment of tyrosinemia type 1 and is now the mainstry of therapy. Case presentation: Our case was a girl in midchidhood period with profound rickets and slowly progressing liver disease who presented with difficulty walking and weakness of muscles. She had an elevated serum tyrosine and urinary succinylacetone, which confirmed the diagnosis of tyrosinemia type 1 and after treatment with NTBC significant remission, was achieved.
https://ijp.mums.ac.ir/article_2999_3d581d5b0c777d03bb553cb5a2646f73.pdf
2014-09-01
63
66
10.22038/ijp.2014.2999
Hypophosphatemic rickets
Type 1 Tyrosinemia
Peyman
Eshraghi
eshraghip2@mums.ac.ir
1
Department of Pediatric Endocrinology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Foad
Faroughi
faroughif891@mums.ac.ir
2
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Mohammad Karim
Alizadeh
3
Student Research Committee, Faculty of Paramedicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
1. Kitagawa T. Hepatorenal tyrosinemia. Proceedings of the Japan Academy Series B, Physical and biological sciences. 2012;88(5):192-200.
1
2. de Laet C, Dionisi-Vici C, Leonard JV, McKiernan P, Mitchell G, Monti L, et al. Recommendations for the management of tyrosinaemia type 1. Orphanet journal of rare diseases. 2013;8:8.
2
3. Chakrapani A, Gissen P, McKiernan P. Disorders of Tyrosine Metabolism. In: Saudubray J-M, Berghe G, Walter J, editors. Inborn Metabolic Diseases: Springer Berlin Heidelberg; 2012. p. 265-76.
3
4. De Braekeleer M, Larochelle J. Genetic epidemiology of hereditary tyrosinemia in Quebec and in Saguenay-Lac-St-Jean. American journal of human genetics. 1990;47(2):302-7.
4
5. Herbst DA, Reddy KR. Risk factors for hepatocellular carcinoma. Clinical Liver Disease. 2012;1(6):180-2.
5
6. Pagon RA, Bird TD, Dolan CR, Stephens K, Adam MP, King LS, et al. Tyrosinemia Type 1. 2006.
6
7. Holme E, Lindstedt S. Nontransplant treatment of tyrosinemia. Clinics in liver disease. 2000;4(4):805-14.
7
8. Lock E, Ellis M, Gaskin P, Robinson M, Auton T, Provan W, et al. From toxicological problem to therapeutic use: the discovery of the mode of action of 2-(2-nitro-4-trifluoromethylbenzoyl)-1, 3-cyclohexanedione (NTBC), its toxicology and development as a drug. Journal of inherited metabolic disease. 1998;21(5):498-506.
8
9. McKiernan PJ. Nitisinone for the treatment of hereditary tyrosinemia type I. Expert Opinion on Orphan Drugs. 2013;1(6):491-7.
9
10. Bijarnia S, Puri RD, Ruel J, Gray GF, Jenkinson L, Verma IC. Tyrosinemia type I—diagnostic issues and prenatal diagnosis. The Indian Journal of Pediatrics. 2006;73(2):163-5.
10
11. Roth K. Tyrosinemia, 2008 (2009).
11
12. Cassiman D, Zeevaert R, Holme E, Kvittingen E-A, Jaeken J. A novel mutation causing mild, atypical fumarylacetoacetase deficiency (Tyrosinemia type I): a case report. Orphanet journal of rare diseases. 2009;4(1):28.
12
13. Lindblad B, Steen G. Identification of 4, 6‐dioxoheptanoic acid (succinylacetone), 3, 5‐dioxooctanedioic acid (succinylacetoacetate) and 4‐oxo‐6‐hydroxyheptanoic acid in the urine from patients with hereditary tyrosinemia. Biological Mass Spectrometry. 1982;9(10):419-24.
13
14. van Spronsen FJ, Bijleveld CM, van Maldegem BT, Wijburg FA. Hepatocellular carcinoma in hereditary tyrosinemia type I despite 2-(2 nitro-4-3 trifluoro-methylbenzoyl)-1, 3-cyclohexanedione treatment. Journal of pediatric gastroenterology and nutrition. 2005;40(1):90-3.
14
15. Lindstedt S, Holme E, Lock E, Hjalmarson O, Strandvik B. Treatment of hereditary tyrosinaemia type I by inhibition of 4-hydroxyphenylpyruvate dioxygenase. The Lancet. 1992;340(8823):813-7.
15
ORIGINAL_ARTICLE
The Benefits of Honey in Holy Quran
Honey contains a wide variety of vitamins, minerals, amino acids and antioxidants. The vitamins found in honey include niacin, riboflavin and pantothenic acid; minerals present include calcium, copper, iron, magnesium, manganese, phosphorus, potassium and zinc. In addition honey contains a variety of flavonoids and phenolic acids which act as antioxidants, scavenging and eliminating free radicals. Honey has had a long history in human consumption, and is used in various foods and beverages as a sweetener and flavoring. It also has a role in religion and symbolism. Medicinal importance of honey has been documented in the world's oldest medical literatures, and since the ancient times, it has been known to possess antimicrobial property as well as wound-healing activity. More than 1,400 years ago, honey is described as a source of healing in the Quran and it is also mentioned as one of the foods of Paradise.
https://ijp.mums.ac.ir/article_3417_7b73b0cd46a86c1400eaeb1adbf093f6.pdf
2014-09-01
67
73
10.22038/ijp.2014.3417
Benefits
Honey
Quran
Abbasali
Purbafrani
1
Ministry of Health and Medical Education, Tehran, Iran.
AUTHOR
Seyed Amirhosein
Ghazizade Hashemi
2
Assistant Professor of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Saeed
Bayyenat
3
Assistant Professor of Anesthesiology , Department of Anesthesiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
AUTHOR
Habibolah
Taghizade Moghaddam
taghizademh1@mums.ac.ir
4
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Masumeh
Saeidi
5
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
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30. The Noble Quran, Chapter 47:Verse 15.
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ORIGINAL_ARTICLE
Comparison of Immunization in Iran and Turkey between Years 1980- 2013
Immunization is today one of the safest, most cost-effective, and powerful means of preventing deaths and improving lives. Over the years, all countries of the world have incorporated an increasingly broad immunization agenda in their public health interventions. Immunization programmes are now routinely reaching over 80 percent of children under one year of age. Iran and Turkey with a population of nearly the same, are in the neighborhood and the aim of this study is to compare the vaccination situation in the two countries from 1980 to 2013.
https://ijp.mums.ac.ir/article_3418_5ac73b0473d355210722baf71c85bf9a.pdf
2014-09-01
75
83
10.22038/ijp.2014.3418
Immunization
Iran
Turkey
Vaccination
Seyed Amirhosein
Ghazizade Hashemi
1
Assistant Professor of Otorhinolaryngology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Saeed
Bayyenat
2
Assistant Professor of Anesthesiology , Department of Anesthesiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.
AUTHOR
Abbasali
Purbafrani
3
Medical Education, Ministry of Health and Medical Education, Tehran, Iran.
AUTHOR
Habibolah
Taghizade Moghaddam
taghizademh1@mums.ac.ir
4
Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Masumeh
Saeidi
5
Students Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR