TY - JOUR ID - 2416 TI - McCune-Albright Syndrome: A Case Report and Literature Review JO - International Journal of Pediatrics JA - IJP LA - en SN - 2345-5047 AU - Mobini, Moein AU - Vakili, Rahim AU - Vakili, Saba AD - Department of pediatric Endocrinology and Metabolism, Mashhad university of medical science, Mashhad, Iran. Y1 - 2014 PY - 2014 VL - 2 IS - 2.2 SP - 153 EP - 156 KW - Albright syndrome KW - Fibrous dysplasia KW - McCune KW - polyostotic DO - 10.22038/ijp.2014.2416 N2 - McCune-Albright syndrome (MAS) is a rare, heterogenous, clinical condition caused by a rare genetic mutation. The disorder is more common in females and is characterized by a triad of cutaneous, bone and endocrine abnormalities.  We describe a girl patient with MAS having precocious puberty and multiple cafe-au-lait macules and deforming polyostotic fibrous dysplasia of bone. Clinical presentation and X-ray finding were strongly diagnostic for MAS, Patients with McCune-Albright syndrome reach the adult age with a significant burden of the disease that continuously reduces their quality of life. Skeletal deformities, fractures, hyperthyroidism, and hyperestrogenism are just few of the many challenges in the management of these patients. These disorders with close observation and early detection can be controlled. UR - https://ijp.mums.ac.ir/article_2416.html L1 - https://ijp.mums.ac.ir/article_2416_f3d93c1ae3233d1ae4111fe983169320.pdf ER -