TY - JOUR ID - 6856 TI - An Association Analysis of Reelin Gene (RELN) Exon 22 (G/C), Rs.362691, Polymorphism with Autism Spectrum Disorder among Iranian-Azeri Population JO - International Journal of Pediatrics JA - IJP LA - en SN - 2345-5047 AU - Mehdizadeh Fanid, Leila AU - Hosseinpour Feizi, Mohammad Ali AU - Adampour Zare, Mina AU - Shahrokhi, Hasan AD - Assistant Professor of Cognitive Neuroscience. Department of Animal Biology Faculty of Natural Sciences. University of Tabriz, 29 Bahman Bolvard, Tabriz, Iran, IR. AD - Professor of Radiobiology, Department of Animal Biology Faculty of Natural Sciences. University of Tabriz, 29 Bahman Bolvard, Tabriz, Iran, IR. AD - Physiologist, Department of Animal Biology Faculty of Natural Sciences, University of Tabriz, 29 Bahman Bolvard, Tabriz, Iran, IR. AD - Child and Adolescent Psychiatrist MD, Research Centre of Psychiatry and Behavioral Science, Tabriz University of Medical Science, Tabriz, Iran, IR. Y1 - 2016 PY - 2016 VL - 4 IS - 7 SP - 2027 EP - 2033 KW - Key words: Autism KW - Reelin gene KW - Polymorphism KW - molecular marker DO - 10.22038/ijp.2016.6856 N2 - Background Autism spectrum disorder (ASD) is a intricate childhood neuropsychiatric disorder that is described by deficits in communication of verbal and non-verbal, reciprocal social interactions, stereotypic behaviors, interests, and activities. The studies of post-mortem neuro-anatomical anomalies have indicated that migration alterations could occur early during development (first trimester) in autistic brain. Since the Reelin gene, plays a crucial role in these migratory processes, it is subsequently considered as a potential candidate gene for autism. Materials and Methods In this case-control study, we recruited 74 patients with ASD and 88 healthy controls from Iranian-Azeri Population. Genomic DNA isolated from blood leukocytes of cases and control individuals by the proteinase K and using salt-out method. Single nucleotide polymorphisms (SNP) genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Results The allele and genotype frequencies did not show significant difference between autistic and control groups (P>0.05). No significant relationship was observed between the genders and genotypes in autism group (P>0.05). Conclusion The current study showed that the SNPs rs362691 could not be used as a useful molecular biomarker to predict genetic susceptibility for ASD among Iranian-Azeri patients. UR - https://ijp.mums.ac.ir/article_6856.html L1 - https://ijp.mums.ac.ir/article_6856_62fdfcac8ccf35df3a8010ba8eb1267e.pdf ER -