International Journal of Pediatrics

The Effects of Low Level Laser Therapy on the Expression of Collagen Type I Gene and Proliferation of Human Gingival Fibroblasts (Hgf3-Pi 53): in vitro Study

Ali Forouzanfar

Volume 2, Issue 2.3 , May 2014, , Pages 65-65

https://doi.org/10.22038/ijp.2014.2728

Abstract

Background Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study ... Read More

Survey of Caustic Ingestion Symptoms in Children

H Yarmohammadi; N Yarmohammadi; M Mohammadpur

Volume 2, Issue 2.1 , April 2014, , Pages 65-65

https://doi.org/10.22038/ijp.2014.2533

Abstract

Introduction: Complications of caustic ingestion swallowing in children of singe to gullet severe stricture and andoscopic actions and multiple surgeries Is different that increase ... Read More Introduction: Complications of caustic ingestion swallowing in children of singe to gullet severe stricture and andoscopic actions and multiple surgeries Is different that increase the risk of gastrointestinal perforation and gastrointestinal malignancies ..... Because Acid substances have bad taste and these are tissue coalescence in location of contact thus attribute alkali make lose of injury. In other words,alkalis substance are weak and attribute to acids make a more severe tissue damage.but,in any form, acids and alkalis conscious Serious damage to the gastrointestinal tract, particularly the esophagus if swallowed. Pipe solutions, batterie water, disinfectant, liquid bleach, detergen, salt ink,….are torrid substance that make a esophageal burns fairly common in children. Results: Acidic or alkaline Caustic ingestion in children 1 to 5 years old. Severe burns Ingestion pipe , battery water, solid, strong alkaline compound that is used as a pipe ) are more common . house hold bleach swallowing ,shampoo,Soap in low value make a little damage to the gastrointestinal tract; but how ever this children in first opportunities should Be examined by physician. Materials and Methods: This study is review of studies motor research google, pubmed, web of knowledge, science direct, Cochrane and were used of key words: symptoms, swallow, torrid substances, children. Conclusions: torrid substances Swallowing in children often occurs randomise. Symptoms include runny mouth, restlessness , difficulty or painful swallowing , vomiting blood, abdominal pain and mouth burns and lips . Note that inflammation may be a little sore around the mouth and inward lips not seen the baby's mouth , but contemporary, severe burns of the esophagus exist should be taken to the phisision. The most effective action about torrid substances Swallowing by children ,is prevent it. Due to the importance in many national poisoning , provide specialized information . Due to the caustic ingestion in children is easily preventable , it is necessary importance to family physicians and the public Health Personnel be clear. Media , newspapers , radio and tv have effective role in increasing awareness poisoning , especially the poisoning by acids substances. Key words: Children, Symptoms, Swallow, Torrid Substances.

Noninvasive Stem Cell Labeling Using USPIO Technique and their Detection with MRI

Ayoob Rostamzadeh; Arash Shabani; Reza Ahadi; Mohammad Farzizadeh; Alireza Gharib; Saber Miraki

Volume 2, Issue 2.3 , May 2014, , Pages 66-66

https://doi.org/10.22038/ijp.2014.2729

Abstract

Background: To date, several imaging techniques to track stem cells are used such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Bioluminescence ... Read More Background: To date, several imaging techniques to track stem cells are used such as positron emission tomography (PET), single photon emission computed tomography (SPECT), Bioluminescence imaging (BLI), fluorescence imaging, CT scan and magnetic resonance imaging (MRI). Although, overall sensitivity of MRI compared to SPECT and Bioluminescence techniques are lower, but due to high spatial resolution (~100 mm), long term three-dimensional imaging capability, in vivo quick access to images in three different sections, and noninvasiveness it is being used as the method of choice. Methods: The present study is the search results for authors and sources of information in the field of molecular and cellular imaging to examine the problems and perspectives about stem cells labeling with Ultrasmall Super Paramagnetic Iron Oxide (USPIO) and their tracking by MRI. Results: With the advancement of technology, including quantum physics, chemistry, and computer software, MRI with an excellent spatial resolution and contrast, is surpasses other imaging modalities in the analysis of anatomical and pathological features and images of all body tissues. From the other side, advances in the astronomical science, chemistry and nanotechnology, high biocompatibility and cytotoxicity of nanoparticles, and due to analysis in the metabolic pathways of iron made the procedure easier; however, there are still several fundamental questions in understanding the mechanism of biological molecules in the living cells including: 1- How to detect not only the location but also the performance of the labeled cells? Probably combination of USPIO nanoparticles with other reporter genes as contrast agents for MRI and PET can simultaneously be used to overcome these limitations 2) How to trace stem cells from pre-clinical models to translate to humans? Up to now, due to issues of bioethics, little studies have been done in this area. 3) Whether the transplanted stem cells that have reached the target tissue, will remain or migrate? Despite the fact that cell proliferation and exocytosis are two main factors for long term protection of USPIO nanoparticles inside cells, their signals cannot be received for a long time. 4) What mechanisms cause stem cells reaching the target tissue to react with their environment? And 5) what is the number of transplanted cells in live tissue, and what is their half-life? Conclusion: This study showed that USPIO nanoparticles can enter the cell with a clear dose without any adverse biological effects and could be detected by SWI and T2* techniques under MRI (1.5 Tesla) scanner for almost one month. MRI as a secure mean can illustrate with optimal resolution the spatial-resolution and three-dimensional positions of the stem cells. Keywords: Ultrasmall Super Paramagnetic Iron Oxide (USPIO), labeled stem cell, in vivo tracking, MRI.

Evaluation of Antibody Response to Polysaccharide Vaccine and Switched Memory B Cells in Pediatric Patients with Inflammatory Bowel Disease

Gh Fallahi; A Aghamohammadi; A Khodadad; M Hashemi; P Mohammadinejad; H Asgarian-Omran; M Najafi; F Motamed; Kh Soleimani; H Soheili; N Parvaneh; B Darabi; R Nasiri Kalmarzi; Sh Pourhamdi; H Abolhassani; B Mirminachi; N Rezaei

Volume 2, Issue 2.1 , April 2014, , Pages 66-66

https://doi.org/10.22038/ijp.2014.2534

Abstract

Background/Aims: Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract, whose etiologies are still unknown. This study was performed to evaluate the humoral ... Read More

Variations of the Normal Human Limbal Stem Cells Detected by In Vivo Confocal Microscopy

Siamak Zarei-Ghanavati; Juan A. Ramirez-Miranda; Sophie X. Deng

Volume 2, Issue 2.3 , May 2014, , Pages 67-67

https://doi.org/10.22038/ijp.2014.2730

Abstract

Background To report normal variations of the limbal structures using in vivo laser scanning confocal microscopy. Methods: This was a retrospective study of fourteen eyes ... Read More

The Study of Levofloxacin Effects on Liver Tissue in Wistar Rat

N Vahidieyerisofla; M Ahmadi Far; M RabieeGolmakani; A Mohammad Eini

Volume 2, Issue 2.1 , April 2014, , Pages 67-67

https://doi.org/10.22038/ijp.2014.2535

Abstract

Introduction In this study, we examined the effects of the antibiotics levofloxacin on the liver as well as its devastating effects which are ensued from its over-prescription. Levofloxacin ... Read More Introduction In this study, we examined the effects of the antibiotics levofloxacin on the liver as well as its devastating effects which are ensued from its over-prescription. Levofloxacin serves as one of the antibiotics of genitourinary system and inferior respiratory system. Since liver is the foremost organ that receives all the materials absorbed by intestine through the portal vein, and it is the organ that must neutralize venoms, the toxic effect of most medications on liver manifest itself quicker than other organs. Materials and Methods: for this study, 50 series of male rats from the strains of Wistar were used; the rats were eight weeks old and had a weight of about 250 g. During the study which lasted 60 days, the rats were exposed to lightness and then darkness for 12 hours respectively. The room temperature stood at 24.7-26.4 ° C as its moisture was counted as %55-60.30 series of rats were divided into three groups, receiving the antibiotics with different dilutions; 250,500 and 750 ml; the drug is taken orally. 20 series of rats were put in to the two groups—control and sham; the first group received treatment as the sham group received water through gavage. After the completion of this round, blood samples were taken from all groups, and dispatched to laboratory for medical diagnosis. The rats were then anesthetized with ether and slit open from the peritoneal area as transverse-abdominal cut, letting the liver out of the body; the samples of the liver tissue were stabilized in 10% formalin and sent to pathology laboratory for block making and preparing the slides. Result: Comparing the enzyme levels of SGOT and SGPT in the treatment, control and sham groups, it represented that there was a rise in the enzyme levels as a result of liver damage caused by taking antibiotics. Observing the microscopic slides of the liver tissue of the treatment group, it suggests sinusoid destruction, the loss of bile ducts, irregular placement of adjacent cells and the absence of Kupffer cells, which in turn confirms the negative effect of levofloxacin on liver tissue. Conclusion: Like other medications, levofloxacin can exert adversary effects as well as positive effects. Since one of the tissues which is susceptible to this effect is liver, we must bear in mind when it comes to prescribing this medication. Key words: Antibiotic, Levofloxacin, Liver .

Expressional Analysis of Stem Cell Marker SALL4 in Mesencephalon during Chicken Embryogenesis

Malihe Bahadori; Saedeh Zafar-Balannezjad; Mohammad Mahdi Forghanifard

Volume 2, Issue 2.3 , May 2014, , Pages 68-68

https://doi.org/10.22038/ijp.2014.2731

Abstract

Background SALL gene family represent a group of evolutionary conserved zinc finger transcription factors which are involved in normal development. It includes four members (SALL1 ... Read More

Evaluation of Bone Mineral Density in Children with Acute Lymphoblastic Leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL)

A Ghasemi; A Banihashem; N Ghaemi; S Elmi; H Esmaeili; R Erfani Sayyar; Sam Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 68-68

https://doi.org/10.22038/ijp.2014.2536

Abstract

Introduction: Acute lymphoblastic leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) are the most common childhood and adolescence malignancy respectively.Due to the increasing survival ... Read More Introduction: Acute lymphoblastic leukemia (ALL) and Non-Hodgkin's Lymphoma (NHL) are the most common childhood and adolescence malignancy respectively.Due to the increasing survival of these children, today late side effects of treatments are important. Therapies such as corticosteroids, cytotoxic and radiotherapy effect on bone density and put the child at risk of osteoporosis and pathological fractures. Material and Methods: This 3-year cross sectional study was performed in Dr. Sheikh Children's Hospital in Mashhad on 50 children with ALL (n=25) and NHL (n=25). Half of them were received (n= 25) chemotherapy alone and half of them chemotherapy plus radiotherapy (n=25). All children were in the remission phase. We assessed them by DEXA bone mineral densitometry (BMD) on the lumbar spine and femoral neck (hip). We also measured some bone biomarkers include calcium (ca), phosphorus (p), parathoromone (PTH), alkaline phosphatase (ALP) in plasma. Results by age, height, sex and Body Mass Index (BMI) were adjusted with a special software. Results: Mean age was 8.28 ± 3.93 years. There was no significant difference on bone biomarkers (Ca, P, ALP.PTH) between ALL, NHL and also between the two treatment groups. Children with ALL had lower density at the hip and lumbar spine. (Respectively p value < 0.001 and p value =0.018 ) . A total of 50 patients, the hip BMD showed normal results in 3 patients (6%) , in 14 patients (28%) osteopenia were seen and 33 patients (66%) had osteoporosis. In whom received radiotherapy plus chemotherapy, one patient had normal BMD and 24 patients (48% of total patients) at the hip and 22 patients (44%) at lumbar spine had decreased BMD. In contrast, in whom had only chemotherapy, 24 patients (48%) had osteoporosis at hip and 23 (46%) at the lumbar spine. There was no significant difference in BMD between the sexes. Conclusion: Given that 94% of children had abnormal bone density, Seem to pay more attention to the metabolic status and BMD in children with cancer can develop appropriate strategies to improve health and quality of their life. Keywords: Acute Lymphoblastic Leukemia (ALL), Bone Mineral Density, chemotherapy, Non-Hodgkin's Lymphoma (NHL), Radiotherapy.

Different isolation methods of dental pulp stem cells

Solmaz Pourgonabadi; Zahra Tayarani-Najaran

Volume 2, Issue 2.3 , May 2014, , Pages 69-69

https://doi.org/10.22038/ijp.2014.2732

Abstract

Considering the ease of isolation and high expansion potential of pulp stem/progenitor cells isolated from wisdom and primary teeth they have been implicated as the most reliable autologous ... Read More Considering the ease of isolation and high expansion potential of pulp stem/progenitor cells isolated from wisdom and primary teeth they have been implicated as the most reliable autologous cell source in dental tissue engineering. Meanwhile, different isolation methods have remarkable impacts on the expansion potential of adult stem cells. In enzymatic digestion method extracted teeth as dental pulp sources are kept in PBS or medium containing at least 2 % (w/v) antibiotics until isolation procedure. Permanent teeth fractured with a mini hammer in order to get access to the pulp chamber and root canals. After washing with sterile PBS, pulp tissue cut into small pieces as much as possible (~1 mm 3 pieces). Tissue pieces are washed six times with sterile PBS containing 1% antibiotic and 1% amphotericin and placed in 1 ml a solution of trypsin for 15 min in 37°C. Afterthought, tissues were cut in to smaller pieces and placed in six well plates for 10 min to dry. There are some variations in the mentioned method, for instance; using different enzymatic combination of collagenase type I and dispase instead of trypsin. In outgrowth methodpulp tissue placed directly in a cell culture plate with the growth medium after washing with sterile PBS and cutting into small pieces. In the present review, we discuss pros & cons of culturing human dental pulp of wisdom teeth using two methods; enzymatic digestion and outgrowth of stem cells from pulp tissue explants. The most significant differences in enzymatic digestion and outgrowth methods are in reported cell number and homogeneity. While the former is always higher in enzymatic digestion, tissue explants allow the expansion of fibroblastic-like cells in dental pulp cultures. Moreover, isolated dental pulp stem cell in outgrowth method is lower than enzymatic digestion in number but in homogeneity is higher than enzymatic digestion. Kay words: Dental pulp stem cell, Isolation,enzymatic digestion, Outgrowth.

Infective Endocarditis in Children Hospitalized During 10 Years in Imam Reza Hospital- Mashhad

H Mottaghi Moghadam; M Horri; S Elmi; N Motevalli Haghi; R Erfani Sayyar; Sh Rahmani; Sam Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 69-69

https://doi.org/10.22038/ijp.2014.2537

Abstract

Introduction: Infective endocarditis is a rare, fatal ,with high morbidity in children, Since infective endocarditis in children was not assessed in our conditions so our study was ... Read More

Tissue Engineering in Dentistery

Saedeh khajehahmadi

Volume 2, Issue 2.3 , May 2014, , Pages 70-70

https://doi.org/10.22038/ijp.2014.2733

Abstract

Introduction Perforation of maxillary sinus mucous membrane is of the most prevalent complication during open sinus lift surgery. Moreover, such complication can usually be managed ... Read More

The Efficacy of Citalopram in the Treatment of Functional Abdominal Pain in Children: A Randomized, Double-Blind, Placebo-Controlled Study

Z Pourmoghaddas; H Saneian

Volume 2, Issue 2.1 , April 2014, , Pages 70-70

https://doi.org/10.22038/ijp.2014.2538

Abstract

Introduction: Limited data are available on the effectiveness of antidepressants in the treatment of functional gastrointestinal disorders in children. We evaluated the effectiveness ... Read More

Investigating the Ethical Challenges of Researches and Treatments Using Stem Cells

Z Behroooznia; S Mansouri Majoufardi; Z Hazratian Azizi

Volume 2, Issue 2.3 , May 2014, , Pages 71-71

https://doi.org/10.22038/ijp.2014.2734

Abstract

Background Nowadays using the stem cells has opened a new horizon in the medical science and is indeed a practical and non-invasive method for treating refractory diseases such as ... Read More Background Nowadays using the stem cells has opened a new horizon in the medical science and is indeed a practical and non-invasive method for treating refractory diseases such as Leukemias , lymphomas, blood disorders and so on. Nonetheless, proper and sustainable uses of such powerful cells undoubtedly need to be as per certain ethical principles. of the existing challenges in using stem cells, we could mention issues such as: the resources used for stem cells such as fertilization and intentional abortions, generating embryos merely for laboratory studies, commercial benefits, the degree of accuracy in satisfaction, pushing therapeutic cloning towards reproductive cloning and exaggerated propagations on treatments using stem cells. Investigating the ethical challenges of researches and treatments using stem cells as well as providing suggestions on solving some ethical issues. Methods The research methods are based on using the existing library resources such as books, domestic & foreign magazines as well as the internet websites bearing ethical codes. Results Considering the extensive use of the stem cells, realistic programming for solving the ethical issues seems to be essential. using replacement resources for stem cells including: IVF surplus embryos, aborted fetuses, the embryos produced by Therapeutic cloning via Somatic cell nuclear Transfer (SCNT), Induced pluripotent stem cells (iPS), and parthenogenesis are recommended. Definitely, any of the suggested replacement resources have got their own ethical and complicated issues. promoting development of public umbilical cord blood blanks in order to maintain fairness among various social classes, carrying out the preclinical researches and risk to benefit analysis, performing systematic researches, refusing to pay against donation of gametes & embryos, Recommending cellular-therapy only in case it is safer than other available therapeutic methods. Informing the patient of the adverse effects of cellular therapy, providing the low income patients with financial supports via health insurances, using moral manuals and lastly stressing on religious ethics in line with medical ethics and expanding research and studies on the use of adults' stem cells are recommended as replacement methods. Key words: cellular therapy, cloning, Medical ethics, Stem cells, Research ethics.

Study on Endoscopic Results in Children Admitted with Caustic Ingestion at Ghaem Hospital in 2011-2013

MA Kiani; M Zakerian; E Roudi; M Sabbagh

Volume 2, Issue 2.1 , April 2014, , Pages 71-71

https://doi.org/10.22038/ijp.2014.2539

Abstract

Introduction: Esophagus injuries secondary to caustic ingestion occurs frequently in children. Oral damages cannot give us a clear image of what has happened in upper GI. Therefore ... Read More

The Role of Stem Cell Therapy in Multiple Sclerosis: an Overview of the Current Status of the Clinical Studies

Rokhsareh Meamar; Leila Dehghani; Shahrzad Nematollahi; Amirpoya Tanhaee

Volume 2, Issue 2.3 , May 2014, , Pages 72-72

https://doi.org/10.22038/ijp.2014.2735

Abstract

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promise treatments in MS urge us to plan new and more effective therapeutic approaches that aim to ... Read More

Wilson’s Disease: Nutrition Support

M Ghayour-Mobarhan; M Mazidi

Volume 2, Issue 2.1 , April 2014, , Pages 72-72

https://doi.org/10.22038/ijp.2014.2540

Abstract

Wilson’s disease (WD) or hepato-lenticular degeneration is a rare autosomal-recessive disorder. A prevalence rate of 30 cases per million and a birth incidence rate of one per ... Read More

Genetically Engineered Mouse Embryonic Stem Cell – derived Cardiomyocytes as a Suitable Model on Drugs Toxicity In vitro

Leila Dehghani; Mohammad-Hossein Nasr Esfahani; Soheila Tahani

Volume 2, Issue 2.3 , May 2014, , Pages 73-73

https://doi.org/10.22038/ijp.2014.2736

Abstract

Background DOX is a powerful chemotherapeutic agent used in the treatment of solid tumors and malignant hematological diseases. However, its cardiac toxicity limits the clinical usefulness ... Read More

Comparison of Growth Impairment in Pediatric Patients with ALL, NHL Treated with Chemotherapy alone and Chemoradiotherapy

A Ghasemi; A Banihashemi; N Ghaemi; S Elmi

Volume 2, Issue 2.1 , April 2014, , Pages 73-73

https://doi.org/10.22038/ijp.2014.2541

Abstract

Introduction: Acute Lymphoblastic Leukemia (ALL) and Non Hodgkin’s Lymphoma(NHL) are the most common cancers in childhood and adolescence. Most children with ALL and NHL ... Read More

Tc-99m Labeled HMPAO white Blood Cell Scintigraphy in a patient with Hip Prosthesis

Kayvan Sadri; Kamran Aryana; Susan Shafiei; Sepideh Barati; Seyed Rasoul Zakavi

Volume 2, Issue 2.3 , May 2014, , Pages 74-74

https://doi.org/10.22038/ijp.2014.2737

Abstract

Background The ability to follow the distribution and migration of biologically active cells in human is essential for the development of cell-based therapies and diagnostics. Nuclear ... Read More

Coronavirus (COVID-19) Infection in Newborns

Ahmad Shah Farhat; Seyed Javad Sayedi; Farideh Akhlaghi; Abdolkarim Hamedi; Alireza Ghodsi

Volume 8, Issue 6 , June 2020, , Pages 11513-11517

https://doi.org/10.22038/ijp.2020.48004.3871

Abstract

Background The COVID-19 infection, which has been a pandemic since early 2020, can occur in pregnant women and can be transmitted to the baby after birth. There are few reports of this ... Read More

Nasoalveolar Molding: A new Method for Cleft Lip and Palate Rehabilitation

A Jahanbin

Volume 2, Issue 2.1 , April 2014, , Pages 74-74

https://doi.org/10.22038/ijp.2014.2542

Abstract

Introduction: Cleft lip and palate is a congenital anomaly occurring in 3 in 1000 live birth. One the major concern in this patient is about cleft gap and its surgical problems. Several ... Read More

Repair of Spinal Cord Injury (SCI) Using Bone Marrow Stromal Cell Transfected with Adenoviral Vector Expressing Glial derived Neurotropic Factor (GDNF) in a Rat SCI Model

R Salarinia; A Daei; A Biglari; I Jafari Anarkooli; S Mazloomzadeh; PR Lowenstein

Volume 2, Issue 2.3 , May 2014, , Pages 75-75

https://doi.org/10.22038/ijp.2014.2738

Abstract

Back ground Subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. The Most important of such changes is ... Read More Back ground Subsequent to spinal cord injury many pathological changes may occur that could lead to inappropriate environment for repair. The Most important of such changes is the death of neurons. Exogenous administration of growth factors that modulate neuronal survival, synaptic plasticity, and neurotransmission has been proposed as a potential therapeutic treatment for SCI. Among these growth factors, GDNF is a peptide with pleiotropic survival and growth-promoting effects on neurons. In addition, GDNF induces the growth of motor and sensory axons and inhibits neuronal apoptosis. Adult stem cells may provide new strategies to treat SCI. Among various types of candidate stem cells, bone marrow stromal cells (BMSC) are promising because they have shown potential to neuronal differentiation and repair in damaged spinal cord. In this study, we aimed to improve results of treatment using combination of BMSC and GDNF features. Methods: Rats were divided randomly into four groups of six. Spinal cord injury was then performed under general anesthesia using the weight dropping method. The BMSCs were injected on 3th day of post-spinal cord injury. Group one included rats receiving normal saline, group two received BMSC, group three received BMSC infected with adenoviruses encoding the beta-galactosidase gene, and group four received BMSC infected with adenoviruses encoding the GDNF gene. A Basso, Beattie and Bresnahan (BBB) score test was performed for a period of four weeks. Two weeks before the end of BBB, biotin dextran amine was injected intracerebrally followed by tissue staining at the end of the fourth week. Results: There was a significant difference in BBB scores between groups one and four (p<0.05). BBB scale improved to 12.8 points group one, while it was 8.6 in the control. There were no significant differences between other groups. There were significant differences in axon counting between group one and other groups (p<0.0001). Also, there were significant differences in axon counting between group four with groups two and three (p<0.0001). Conclusion: Combined use of these methods (GDNF expressing BMSCs) showed better results in comparison with BMSC alone. In this study the two methods were used simultaneously. The time of injection of BMSCs is very important and so we suggest that other injection times be tested. Key words: BMSC, GDNF, Gene Therapy, Spinal cord injury.

Refugees in the Eastern Mediterranean Region: Needs, Problems and Challenges

Habibolah Taghizadeh Moghaddam; Seyed Javad Sayedi; Zahra Emami Moghadam; Abbas Bahreini; Maryam Ajilian Abbasi; Masumeh Saeidi

Volume 5, Issue 3 , March 2017, , Pages 4625-4639

https://doi.org/10.22038/ijp.2017.8452

Abstract

As host to some of the world’s biggest emergencies and protracted crises, the Eastern Mediterranean Region carries the largest burden of displaced ... Read More

Severity Assessment of Chronic Liver Disease in Children

S Tehranian; P Shojaee; S Jafarzadeh; HR Kianifar; SA Jafari

Volume 2, Issue 2.1 , April 2014, , Pages 75-75

https://doi.org/10.22038/ijp.2014.2543

Abstract

Introduction: Chronic liver disease and cirrhosis are the most important causes of growth failure, morbidity and mortality in children. Cirrhosis consists of a variety of congenital, ... Read More Introduction: Chronic liver disease and cirrhosis are the most important causes of growth failure, morbidity and mortality in children. Cirrhosis consists of a variety of congenital, genetic, metabolic, and infectious causes in children. Models for predicting of chronic liver disease severity, survival, and transplantation are useful for decision-making as well as medical interventions. The most important application of this model is to estimate the true mortality rate at a specific time. Therefore, it helps the correct selection of patients for liver transplantation. In this study, we examined the relationship between disease severity and pediatric end-stage liver disease (PELD) scoring system in children with chronic liver diseases. Materials and Methods: This cross–sectional study conducted on 106 children with chronic liver diseases from 2011 to 2012 admitted to Ghaem Hospital, Mashhad, Iran. We used the clinical files of the patients to determine PELD score and recorded all information on a special form. Following that, PELD/MELD (model for end-stage liver disease) scores were calculated. SPSS software version 18 was performed for the analysis of the data applying independent t-test. Results: A total of 106 patients, 53% females and 47% males with the mean age of 68.3±41.8 months participated. The most common clinical finding was hepatomegaly (76%), followed by jaundice and splenomegaly. Jaundice, hepatopulmonary syndrome, cirrhosis and splenomegaly were clearly correlated with PELD score. The increasing of PELD/MELD (model for end-stage liver disease) scores were in line with the high level of liver alkaline phosphatase enzyme and there was a significant relation between them (P<0.05). Conclusion: In our study, all the results showed that the scoring system had the reasonable efficiency in the prognosis and morbidity of chronic liver diseases in children, which has been demonstrated in previous studies. Keywords: Chronic liver disease, MELD score, PELD score.

The Current Status of Bone Marrow Transplantation in Treatment of Patients with Hemophilia

Hassan Mansouritorghabeh; Alireza Modarresi

Volume 2, Issue 2.3 , May 2014, , Pages 76-76

https://doi.org/10.22038/ijp.2014.2739

Abstract

Background Bone marrow transplantation (BMT)is nowadays used in various hematological disorders including leukemias. Hemophilia A & B are sex linked bleeding disorders in which ... Read More Background Bone marrow transplantation (BMT)is nowadays used in various hematological disorders including leukemias. Hemophilia A & B are sex linked bleeding disorders in which there are various genetic abnormalities in factor VIII & IX genes. Among various hematological disorders, bleeding disorders mainly hemophilia in now widely treated using plasma derived and recombinant factor VIII & IX concentrates. Day to day transfusion of coagulation factor VIII & IX in current lifelong disorder is a burden for the patients and decrease their quality of life. Although infection of coagulation products with blood-borne viruses that was major concern in treatment of hemophilia has been eliminated nearly complete at the present time, but appearance of factor VIII & IX inhibitors are huge burdens in treatment of hemophilia for both clinicians and patients. In this day and age BMT has gathered new insight and acceptable treatment for many hematological and non-hematological disorders. If BMT will be successful in treatment of hemophilia, it will improve quality of life (by nearly permanent treatment without necessary of daily treatment) and decrease mortality rate (by providing continuous coagulation factor level in blood system). The aim of current study was to determine current role of BMT in treatment of hemophilia A & B and evaluate current usage of BMT for treatment of hemophilia A & B. Methods literature review was done using following key words: “bone marrow transplantation & hemophilia”, “stem cells transplantation & hemophilia”, BMT & hemophilia” in PubMed search engine without any time restriction. In addition the literature search limited to English languages papers. Results After complete search, abstracts of 24 original papers obtained and among them full text of 18 full text of papers accessed. The review of current papers showed that although BMT has been used in a rare cases with hemophilia (mainly hemophilia with another blood disorder), it does not use commonly and currently in treatment of patients with hemophilia A at present time. Literature review showed that scientists now focused on bone marrow transplantation in mouse model of hemophilia. Conclusion The literature review showed that BMT at present time is not common medical procedure and it is now in animal models, stage. Key Words: Bone marrow transplantation, Hemophilia, Treatment.

Volume 12 (2024)

Volume 11 (2023)

Volume 10 (2022)

Volume 9 (2021)

Volume 8 (2020)

Volume 7 (2019)

Volume 6 (2018)

Volume 5 (2017)

Volume 4 (2016)

Volume 3 (2015)

Volume 2 (2014)

Volume 1 (2013)

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract