Journal of Pediatric Perspectives

Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial

Ahmad Shah Farhat; Mona Kabiri; Ezzat Khodashenas; Hassan Birjandi; Samira Alinejad

Volume 11, Issue 12 , December 2023, , Pages 18424-18432

https://doi.org/10.22038/ijp.2023.76250.5393

Abstract

neonates. The purpose of this study is to determine the efficacy of prophylactic parenteral acetaminophen as a safer alternative drug for PDA in preterm infants. Methods: In a randomized ... Read More

Epidemiology of Pediatric Acute Poisoning in Iran: A Systematic Review and Meta-Analysis

Samira Alinejad; Tayyebeh Chahkandi; omid mehrpour; Jeffrey Brent; Seyed Mohammad Riahi

Volume 10, Issue 5 , May 2022, , Pages 16082-16100

https://doi.org/10.22038/ijp.2021.55738.4416

Abstract

Background: The epidemiology of pediatric poisoning differs from one country to another. Due to the scarcity of reviews on this issue in Iran, we performed a systematic review and meta-analysis ... Read More Background: The epidemiology of pediatric poisoning differs from one country to another. Due to the scarcity of reviews on this issue in Iran, we performed a systematic review and meta-analysis of studies providing data on Iranian pediatric poisoning epidemiology.Methods: PubMed, Web of Sciences, Science direct, Embase, Scopus and the Persian databases Magiran, Scientific Information Database (SID), and Iranmedex were searched. Twenty-seven studies published between 2002 and 2019 were included, based on the inclusion and exclusion criteria.Results: 54.7% of the participants in the reviewed studies were male, and 88.1% of them were unintentional. Most of the children were in the age range of 3-5 years. Non-pharmaceutical agents were the most common causes of poisonings (n=7175, 59.2%) and among them, illicit drugs (19.3%) followed by hydrocarbons (16.4%) constituted the most common non-pharmaceutical poisonings. Illicit drugs, especially opioids, showed an upward trend from 2002 to 2019. Among pharmaceuticals, central nervous system (CNS) drugs (50.4%), especially benzodiazepines (BZDs) (25.8%) and analgesics (14.5%), were the most frequent agents implicated. CNS complaints (51.8%), followed by gastrointestinal complaints (27.6%), were the most common symptoms. Ingestion was the most common route of poisoning (22.1%). Most of the poisoning cases occurred in summer (28.2%). 21.7% of the cases were hospitalized and the mortality rate was 0.8%. A remarkable downward trend in both hospitalization and death rates occurred over time.Conclusion: Overall, non-pharmaceutical toxicity was found to be the most common cause of poisoning. However, considering the agents separately, pharmaceuticals, illicit drugs, and hydrocarbons were the most common causes of poisoning, respectively. In contrast to the decreasing trend in hydrocarbons, pesticides, and pharmaceutical poisonings, we found an increase in opioid poisoning during our study period.

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Author = Alinejad, Samira

Evaluating the Effect of Prophylactic Acetaminophen in the Prevention of Patent Ductus Arteriosus (PDA) in Premature Neonates: A randomized clinical trial

Abstract

Epidemiology of Pediatric Acute Poisoning in Iran: A Systematic Review and Meta-Analysis

Abstract