1 Children and Adolescent Health Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.

2 Assistant Perofessor of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.


Regarding abnormalities in thalassemia major (TM) patients and the effects of leptin and ferritin on heart, aimed to investigate the possible relationship between leptin, ferritin and cardiac involvement in TM patients compared to controls.
Materials and Methods
In total 141 individuals entered to the present case-control study that consisted of 66 TM patients matched in age and sex with 75 healthy controls. The case group selected from those patients attending to the clinic of Ali Asghar Hospital, Zahedan-Iran. From participants, 5ml blood takes by a nurse and was isolated from serum samples in order to analyze ferritin and leptin levels. Major proceedings in patients were checking medical history, physical examination, chest X-ray and Electrocardiogram (ECG) that performed before echocardiography by unique cardiologist. The participants subjected to conventional examination for both right and left heart functions.
Leptin level (p=0.026), height, weight and body mass index (BMI) were lower in patients (p<0.001). Ferritin levels were 4,625.515±3,782.618 and 49.387±25.386ng/ml in patients and controls, respectively (p<0.001). Serum Leptin and ferritin levels were similar in different age groups of patients (p>0.05). In left heart, LAd was higher in case (2.44± 0.42) significantly (p<0.001). QT (p<0.001), QTc (p<0.001), S in V1 (p=0.030), and Heart rate (P<0.001) were higher in TM patient. In patients, QTc (p=0.009), and QTcd (p=0.002) correlated with leptin, and IVSS (p=0.013), PWD (p=0.048), and in right heart, peak E (p=0.002), and peak A (p=0.034) were correlated with ferritin.     
From the present study concluded that PWD and IVSS in left heart and Peak A and Peak E in right heart correlated with ferritin. QTc and QTcd correlated with leptin.