1 Professor of Pediatric Cardiology, Research center for children and adolescent’s health, Resistant Tuberculosis institute,Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2 Assistant Perofessor of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.

3 Assistant Professor of Pediatric Endocrinology, Resistant Tuberculosis institute, Research Center for Children and Adolescent’s Health, Zahedan University of Medical Sciences, Zahedan, Iran.

4 Assistant Professor of Demography, Children and Adolescent Health Research Center, Resistant Tuberculosis institute, Zahedan University of Medical Sciences, Zahedan, Iran.


Respiratory Distress (RD) is a life-threatening respiratory failure. This study aimed to evaluate the diagnostic value of N-terminal prohormone of brain natriuretic peptide (NT-pro-BNP) in distinguishing respiratory and heart diseases in neonates.
Materials and Methods
Hundred fifty neonates aged 2-3 days randomly collected from those who hospitalized in the related ward of the Ali Ebne Abitaleb Hospital, Zahedan, Iran. After sampling 2ml blood from venipuncture by trained nurse in the related ward separated serums performed in a laboratory. Then, 250 μl of the patients’ serum was isolated to assess NT- pro-BNP level using ELISA kit (USA). Data were analyzed using SPSS software version 20.0 with considering of P< 0.05.
Mean of NT-pro-BNP in respiratory, Acyanotic, cyanotic and controls were 386.22±208.82, 384.83±183.74, 372.23±143.04, and 161.70-± 121.2, respectively. Weight, height and head circumference had different mean ranks for respiratory, Acyanotic, cyanotic and healthy groups, respectively (P<0.05).
According to the results, despite of some reports, NT-proBNP is good biomarker to determine differentiate between cardiac and respiratory during neonate.