1 Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

2 Ph.D of Social Work, Clinical Research Development Center of Panzdah-e Khordad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Ph.D. of Social Work, Social Work Department, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

4 Ph.D. of French Literature, Faculty of Foreign Languages, Islamic Azad University Central Tehran Branch, Tehran, Iran.

5 Ph.D. of English Literature, College of Human Sciences, University of South Africa, South Africa.

6 Department of Biostatistics, Ilam University of Medical Sciences, Ilam, Iran.

7 Ph.D Student of Behavioral Sciences, Social Determinants Of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran.

8 Nursing Research Center, Kerman University of Medical Sciences, Kerman, Iran.


Background: With the establishment of new technologies in the search for a cure for hemophilia, non-pharmacological treatments have had a more important role in increasing life expectancy, quality of life of children suffering from hemophilia disorders. The aim of the systematic review was a comprehensive understanding of Non-pharmacological treatment on Iranian children with hemophilia.
Materials and Methods: In this systematic review, articles published in national (Irandoc, Magiran, Medlib, and SID), and international databases (Medline [via PubMed], EMBASE, Web of Science, Scopus and Cochran Central Register of Controlled Trials) were searched without any time limitation till to June, 2019. The keywords of the search include (Child OR Children) AND (Hemophilia OR Hemophiliac) AND (Iranian or Iranian). To assess the quality of the articles intered into the search, we utilized the 5-item Jadad scale.
Results: Six studies were included in the systematic review. The achieved results suggested psychological training can alleviate the test anxiety, life expectancy. Yoga has a significant role in lessening the rate of bleedings, referrals to the haemophilia clinic, and the school non-attendance. Body vibration training has some benefits such as quadriceps strength, bone mineral density, and the functional capacity. Program management by nurse or own children have significant improvement on quality of life of children suffering from hemophilia disorders.
Conclusion: The achieved results suggested policymakers take heed of this novel treatment and non-pharmacological approaches such as psychological training, yoga, body vibration training and its effects on alleviating non-pharmacological treatment on children with hemophilia.