Many children who undergo surgery experience significant perioperative anxiety. Preoperative anxiety can prolong induction of anesthesia and postoperative recovery, increase the risk of postoperative delirium, increase pain, and increase analgesic use. Researchers are looking for ways to treat or prevent preoperative anxiety in children and possibly reduce its negative effects after surgery, such interventions include non-pharmacological and premedication interventions with sedation drug prior to surgery. Pretreatment, however, is often performed for children but it is not clear what the best medicine is and how it is prescribed. Among the ways to reduce children's anxiety, the anesthesiologist can use a combination of methods to achieve the best results.