Clinical and Laboratory Characteristics of Kawasaki Disease in Iran: A Systematic Review and Meta-analysis

Authors

1 Epidemiologist and Research Assistant, Amir Kabir Hospital, Amiralmomenin Hospital, Ayatollah Khansari Hospital, Arak University of Medical Sciences, Arak, Iran.

2 Pediatric Cardiologist, Amir Kabir Hospital, Arak University of Medical Sciences, Arak, Iran.

Abstract

Background
Kawasaki Disease (KD) is a common systemic vasculitis, which mostly develops in childrenunder five years. Based on our knowledge no meta-analysis, studies have been conducted to evaluate the clinical and laboratory findings of KD in Iran. We aimed to evaluate these characteristics in Iranian children with KD.
Materials and Methods: In this Systematic review, online databases, including Medline, Scopus, Web of Science, EMBASE, Medlib, SID, Magiran, and Irandoc were searched until February 2020. The keywords of KD and characteristics were combined and searched. Search, and extraction of papers were performed by two authors independently. The prevalence rates of all clinical and laboratory characteristics of KD and involvement of other organs were analyzed by the random effect model using the STATA software (version 11.0).
Results: Twenty studies were included. In clinical findings among KD patients fever was 100%, change in oral cavity and lips was 82%, bilateral conjunctiva was 78%, rash was 74%, change in extremities was 62%, agitation was 53%, and cervical lymphadenopathy was 50%. In laboratory findings, ESR was 86%, CRP was 67%, leukocytosis was 62%, Hb
Conclusion
The fever, erythrocyte sedimentation rate, and desquamation are the most prevalent clinical, laboratory, and involvement of other organ characteristics respectively.

Keywords