Respiratory involvement in cystic fibrosis (CF) is one of the most complaints in pulmonary disorders. Though symptomatic treatment of the patients with chemical medications is efficient in sign reduction, medications side effects and permitting the disease to become chronic are precarious for patients. Today, the World Health Organization considers traditional medicine. Iranian Traditional Medicine (ITM) makes a priority for disease prevention by suggesting some strategies. We intended to investigate the lifestyle effect on cystic fibrosis patients. In this review, we searched the most important ITM sources [such as Qanoon fi al-teb (The canon of medicine), Zakhire-Kharazmshahi ,and Exir-Azam), and scientific databases such as Data sources included (Pub Med and Google Scholar] in English and without time restriction from inception up to April 2020. According to ITM, the six essential principles must be observed in the management of patients with thick and sticky airway secretions that include nutritional pieces of advice about food and drink, exercise quality, evacuation and retention quantity, advising calmness, no prolonged and daytime sleep and avoidance from air pollution. Anunhealthy lifestyle can play an important role in these patients that confirmed by classical medicine. Therefore, further clinical trials should be performed to confirm the long-term efficacy of a healthy lifestyle in cystic fibrosis patients’ management.