Document Type : case report


1 Department of Obstetrics and Gynecology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Department of Obstetrics and Gynecology, Maternal, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

3 Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

4 Department of Perinatology, Shahid Akbarabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

5 Department of Pediatric Surgery, Ali-Asghar Children Hospital, Iran University of Medical Sciences, Tehran, Iran.

6 Assistant Professor, Department of Obstetrics and Gynecology, Faculty of Medicine, Alborz University of Medical Sciences, Tehran, Iran.


Background: Lipoblastoma is one of the rare masses in childhood and its diagnosis is very uncommon in the perinatal period, so we reported a case with a diagnosis of this mass during pregnancy.
Case Report: In a routine third-trimester ultrasound at 28 weeks, a hyperechoic mass in the size of 27*30mm was detected in between labia majora. However, no abnormal findings were found in perinatal care before this gestational age. Finally, after the birth, at 40 weeks of gestation, the mass was resected and now the baby is in good condition and no recurrence has occurred. There was also an anorectal anomaly associated with this mass in our patient who underwent Anorectoplasty surgery.
Conclusion: Due to the rarity of these tumors, it is important to diagnose them in the perinatal period and to investigate other associated anomalies.


  1. Séguier-Lipszyc E, Baazov A, Fichman S, Ash S, Freud E. Current management of lipoblastoma. European journal of pediatrics. 2018; 177(2):237-41.
  2. Shen LY, Amin SM, Chamlin SL, Mancini AJ. Varied presentations of pediatric lipoblastoma: case series and review of the literature. Pediatric Dermatology. 2017; 34(2):180-6.
  3. Susam‐Sen H, Yalcin B, Kutluk T, Cahit Tanyel F, Haliloglu M, Orhan D, et al. Lipoblastoma in children: review of 12 cases. Pediatrics International. 2017; 59(5):545-50.
  4. Kok KY, Telisinghe PU. Lipoblastoma: clinical features, treatment, and outcome. World journal of surgery. 2010; 34(7):1517-22. 
  5. Jaffe RH. Recurrent lipomatous tumors of the groin: liposarcoma and lipoma pseudomyxomatous. Arch Pathol. 1926; 1:381-7.
  6. Vellios F, Baez J, Shumacker HB. Lipoblastomatosis: A tumor of fetal fat different from hibernoma. The American journal of pathology. 1958; 34(6):1149.
  7. Chung EB, Enzinger FM. Benign lipoblastomatosis. An analysis of 35 cases. Cancer. 1973; 32(2):482-92.
  8. Wax JR, Pinette MG, Mallory B, Carpenter M, Winn S, Cartin A. Prenatal sonographic diagnosis of a perineal lipoma. J Ultrasound Med Wiley Online Library. 2010; 29:1257–9.
  9. Childress, K. J., Hicks, J., Wu, H., Brandt, M. L., & Adeyemi-Fowode, O. A. "Lipoblastoma of the labia: a case report." Journal of Pediatric and Adolescent Gynecology 29.6 (2016): e97-e99.
  10. Abdul-Ghafar, J., Ahmad, Z., Tariq, M.U. et al. Lipoblastoma: a clinicopathologic review of 23 cases from a major tertiary care center plus detailed review of literature. BMC Res Notes 11, 42 (2018).
  11. Lorenzen JC, Godballe C, Kerndrup GB. Lipoblastoma of the neck: a rare cause of respiratory problems in children. Auris Nasus Larynx. 2005; 32(2):169-73.
  12. Mentzel T, Calonje E, Fletcher CD. Lipoblastoma and lipoblastomatosis: a clinicopathological study of 14 cases. Histopathology. 1993; 23(6):527-33.
  13. Kransdorf MJ. Benign soft-tissue tumors in a large referral population: distribution of specific diagnoses by age, sex, and location. AJR. American journal of roentgenology. 1995; 164(2):395-402.
  14. Collins MH, Chatten J. Lipoblastoma/lipoblastomatosis: a clinicopathologic study of 25 tumors. The American journal of surgical pathology. 1997; 21(10):1131-7.
  15. Miller GG, Yanchar NL, Magee JF, Blair GK. Tumor karyotype differentiates lipoblastoma from liposarcoma. Journal of pediatric surgery. 1997; 32(12):1771-2.
  16. Sawyer JR, Parsons EA, Crowson ML, Smith S, Erickson S, Bell JM. Potential diagnostic implications of breakpoints in the long arm of chromosome 8 in lipoblastoma. Cancer genetics and cytogenetics. 1994; 76(1):39-42.
  17. Hicks J, Dilley A, Patel D, Barrish J, Zhu SH, Brandt M. Lipoblastoma and lipoblastomatosis in infancy and childhood: histopathologic, ultrastructural, and cytogenetic features. Ultrastructural pathology. 2001; 25(4):321-33.